Pairwise Alignments

Query, 894 a.a., DNA topoisomerase (ATP-hydrolyzing) subunit A from Vibrio cholerae E7946 ATCC 55056

Subject, 878 a.a., DNA gyrase, A subunit from Enterobacter asburiae PDN3

 Score = 1322 bits (3422), Expect = 0.0
 Identities = 674/896 (75%), Positives = 776/896 (86%), Gaps = 27/896 (3%)

Query: 1   MSDLAKEITPVNIEDELRSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMNVLGNDWN 60
           MSDLA+EITPVNIE+EL+SSYLDYAMSVIVGRALPDVRDGLKPVHRRVL+AMNVLGNDWN
Sbjct: 1   MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWN 60

Query: 61  KAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAM 120
           KAYKKSARVVGDVIGKYHPHGD+AVYDTIVRMAQPFSLRYMLVDGQGNFGS+DGDSAAAM
Sbjct: 61  KAYKKSARVVGDVIGKYHPHGDTAVYDTIVRMAQPFSLRYMLVDGQGNFGSVDGDSAAAM 120

Query: 121 RYTEVRMSKIAHELLADLDKETVDYVPNYDGTEQIPAVLPTKIPNLLINGASGIAVGMAT 180
           RYTE+RMSKIAHEL+ADL+KETVD+V NYDGTE+IP V+PTKIPNLL+NG+SGIAVGMAT
Sbjct: 121 RYTEIRMSKIAHELMADLEKETVDFVDNYDGTERIPDVMPTKIPNLLVNGSSGIAVGMAT 180

Query: 181 NIPPHNLGEVIDGCLAYIDNEAITIDELMDYIPGPDFPTAALISGRKGIIDAYKTGRGKV 240
           NIPPHN+ EVI+GCLAYID+E I+I+ LM++IPGPDFPTAA+I+GR+GI +AY+TGRGK+
Sbjct: 181 NIPPHNITEVINGCLAYIDDEDISIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKI 240

Query: 241 YMRSKAEIETD-KNGKETIIVSEIPYQVNKARLIEKIAELVKEKKVEGISALRDESDKDG 299
           Y+R++AE+E D K G+ETIIV EIPYQVNKARLIEKIAELVKEK+VEGISALRDESDKDG
Sbjct: 241 YIRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDG 300

Query: 300 MRIVIECKRDAVGEVVLNNLYANTQLQTTFGINMVALDNGQPKLFNLKEMLKCFVDHRRE 359
           MRIVIE KRDAVGEVVLNNLY+ TQLQ +FGINMVAL +GQPK+ NLKE+L  FV HRRE
Sbjct: 301 MRIVIEIKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKEILSAFVRHRRE 360

Query: 360 VVTRRTIFELRKARERAHILEGLALALANIDEIIELIRRAATPAEAKEGLIARGWDLGNV 419
           VVTRRTIFELRKAR+RAHILE LA+ALANID IIELIRRA TPAEAK GLI+R WDLGNV
Sbjct: 361 VVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRRAPTPAEAKAGLISRPWDLGNV 420

Query: 420 AAMLERAGTDAARPEWLEPQYGIRDGKYFLTEQQAQAILDLRLHKLTGLEHEKILDEYKQ 479
           AAMLERAG DAARPEWLEP++G+RDG+Y+LTEQQAQAILDLRL KLTGLEHEK+LDEYK+
Sbjct: 421 AAMLERAGDDAARPEWLEPEFGVRDGQYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKE 480

Query: 480 LLEEIAALMHILASTERLMEVIREELEAIRAGFSDARRTEITAATHDIDMEELIAREDVV 539
           LLE+IA L+HIL S ERLMEVIREELE +R  F DARRTEITA + DI++E+LI REDVV
Sbjct: 481 LLEQIAELLHILGSAERLMEVIREELELVRDQFGDARRTEITANSSDINIEDLINREDVV 540

Query: 540 VTLSHEGYVKYQLLSDYEAQRRGGKGKSATKMKEEDYIERLLVANTHDNILLFSTRGKTY 599
           VTLSH+GYVKYQ L+DYEAQRRGGKGKSA ++KEED+I+RLLVANTHD IL FS+RG+ Y
Sbjct: 541 VTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLY 600

Query: 600 RMKVYQLPLASRTARGKPIVNLLPLEENERITAILPVTEFSEDKFIFMATGDGTVKKTSL 659
            MKVYQLP ASR ARG+PIVNLLPLE NERITAILPV E+ E   +FMAT  GTVKKT+L
Sbjct: 601 WMKVYQLPEASRGARGRPIVNLLPLEANERITAILPVREYEEGVNVFMATASGTVKKTAL 660

Query: 660 DQFANVRANGLIALNLRDEDSLIGVDITDGESEIMLFSKFGKVVRFKESEETAVVDENGQ 719
            +F+  R+ G+IA+NL + D LIGVD+T G  E+MLFS  GKVVRFKE+           
Sbjct: 661 TEFSRPRSAGIIAVNLNEGDELIGVDLTSGSDEVMLFSAAGKVVRFKEN----------- 709

Query: 720 PVLDENGQPEIKFKGVRPMGRTAAGVRGMKLADGDQVVSLIVPKTEGDVLTVTENGYGKR 779
                          VR MGRTA GVRG+KLA  D VVSLI+P+ EG +LTVT+NGYGKR
Sbjct: 710 --------------AVRAMGRTATGVRGIKLAGEDSVVSLIIPRGEGAILTVTQNGYGKR 755

Query: 780 TSLSEYPTKGRGTQGVVSIKVSERNGSVVGAVQVAEGDEFMMITNAGTLVRTRVAEVSQV 839
           T+  EYPTK RGTQGV+SIKV+ERNGSVVGAVQV + D+ MMIT+AGTLVRTRV+E+S V
Sbjct: 756 TAEGEYPTKSRGTQGVISIKVTERNGSVVGAVQVDDADQIMMITDAGTLVRTRVSEISVV 815

Query: 840 GRNTQGVTLIRTSEGESVVGLQRIDE-IEESELPEGEEALVENDAPVAQDDDGEQE 894
           GRNTQGV LIRT+E E+VVGLQR+ E +++ EL   + ++ E D  +A + D + +
Sbjct: 816 GRNTQGVILIRTAEDENVVGLQRVAEPVDDEELDSIDGSVAEGDDDIAPEADTDDD 871