Pairwise Alignments

Query, 421 a.a., bifunctional tetrahydrofolate synthase/dihydrofolate synthase from Vibrio cholerae E7946 ATCC 55056

Subject, 450 a.a., Dihydrofolate synthase (EC 6.3.2.12) @ Folylpolyglutamate synthase (EC 6.3.2.17) from Hydrogenophaga sp. GW460-11-11-14-LB1

 Score =  310 bits (793), Expect = 7e-89
 Identities = 186/439 (42%), Positives = 250/439 (56%), Gaps = 27/439 (6%)

Query: 1   MTQKPVPQATSPLAVWLDYLAHIHTSAIDLGLERVQAVAQKAKLTKPAPTVITVAGTNGK 60
           M   PVP   + LA WL +   +H   ID+GLERVQ VA++  L    P VITVAGTNGK
Sbjct: 1   MLDIPVPAHPTTLADWLAHAERLHPVTIDMGLERVQRVARRMGLALDCP-VITVAGTNGK 59

Query: 61  GSTCALMEAILLQAGYSVGVYSSPHLIRYNERVRINGQDLADEMHTQAFAHIE------- 113
           GSTCA++EA+  Q+GY  GVY+SPHL+ + ER R+ G+ +A      AFA +E       
Sbjct: 60  GSTCAMLEAVYTQSGYRTGVYTSPHLVHFEERCRVAGEAVAANDLVPAFAEVEVARKGQV 119

Query: 114 -QERGDISLSLFEFGTLAALYLFEQQKVDVLLLEVGLGGRLDATNVVDHDVSVITSLALD 172
             E G+ISLS FEF TLA L    +  +DV +LEVGLGGRLDA N++D D +VITS+ALD
Sbjct: 120 GDEGGEISLSYFEFTTLAILRTLSRSGLDVAILEVGLGGRLDAVNIIDADCAVITSIALD 179

Query: 173 HTDWLGNDIAVIGYEKAGIFRSGKPAICGQPKPPATVAAHADDIGAKLHQVEIQFSYEKT 232
           H   LGND   IG+EKAGI R+G+P +   P PP ++   A +IGA+L +V   F +   
Sbjct: 180 HMALLGNDREAIGFEKAGIMRTGRPVVVSDPVPPQSILDRAMEIGAELWRVGKDFHF-AG 238

Query: 233 SATTWNW----RSGRFELTDLPIPSL----PLPNAATALMALGC--SGLAISDINIVDGL 282
               W W      G      L  P+L     L NA+  L A+      L ++   + +GL
Sbjct: 239 DQQQWGWAMHPSHGGRRYAGLAYPALRGANQLVNASGVLAAVEALRGRLPVTAQAVRNGL 298

Query: 283 RNAQLAGRMQVISHQPTIVLDVAHNPHSAHYLVQQLTQRYPERTIHLVFGMLHDKDIAST 342
              +L GR Q++   PT+VLDVAHNPHS   L   L       T H VFG + DKD+ + 
Sbjct: 299 ALVELPGRFQIVPGTPTLVLDVAHNPHSVAALAANLDAMGFYPTTHAVFGAMADKDLGAM 358

Query: 343 VVELSPAVTHWYPASLSGPRAATAAQLCQYLPAD-------ITQYANPVSAFEAALTQAG 395
           +  ++P +  W+   L  PRA++AA L + L A          ++  P+ A  AA++ A 
Sbjct: 359 LDRIAPLIDRWHLTDLPLPRASSAAALAEQLEAHPQCKGRLAGRHTGPMDALRAAVSAAD 418

Query: 396 AQDVIVVAGSFHTVGEVLE 414
             D IVV GSF+TVG VL+
Sbjct: 419 PADRIVVFGSFYTVGGVLQ 437