Pairwise Alignments

Query, 528 a.a., cation:proton antiporter from Vibrio cholerae E7946 ATCC 55056

Subject, 558 a.a., predicted transporter with NAD(P)-binding Rossmann-fold domain (NCBI) from Escherichia coli BW25113

 Score =  135 bits (341), Expect = 3e-36
 Identities = 134/532 (25%), Positives = 243/532 (45%), Gaps = 53/532 (9%)

Query: 6   LSAAFLAGFIALKCHLPPLVGFLIAGFALNAY--GFTSNDTLSL-LADLGVTLLLFTIGL 62
           L  AF+ G +A K  + PLVG+L+AG     +  GF ++  L+  LA+LGV LL+F +GL
Sbjct: 15  LVLAFILGMLANKLRISPLVGYLLAGVLAGPFTPGFVADTKLAPELAELGVILLMFGVGL 74

Query: 63  KLEVKTLLAKEIWAGSTIHNLLSTALFTLLLLIFKQLGLDSLADLSFDKLILIGFALSFS 122
              +K L+A +  A       +  A+  + +     + L ++   S    I+ G  LS +
Sbjct: 75  HFSLKDLMAVKAIA-------IPGAIAQIAVATLLGMALSAVLGWSLMTGIVFGLCLSTA 127

Query: 123 STVFAVKSLQEKGEMNATYGTLAIGILVMQDIFAVVFLTA-------------------- 162
           STV  +++L+E+  +++  G +AIG L+++D+  V+ L                      
Sbjct: 128 STVVLLRALEERQLIDSQRGQIAIGWLIVEDLVMVLTLVLLPAVAGMMEQGDVGFATLAV 187

Query: 163 ----STGKLPEWYAIGLFVLPLLRPLFYELLDWVGHGEMLVLFGIFFALVVGAGSFQLVG 218
               + GK+  + AI + V   L P         G  E+  L  +  AL V  G+ +L  
Sbjct: 188 DMGITIGKVIAFIAIMMLVGRRLVPWIMARSAATGSRELFTLSVLALALGVAFGAVELFD 247

Query: 219 MKPDLGALILGMMLASHHKASELSKALFNLKELFLVCFFLNIGLSAHPTTTGIMLALLLL 278
           +   LGA   GM+L     +   +     L++ F V FF+++G+   P    I   L +L
Sbjct: 248 VSFALGAFFAGMVLNESELSHRAAHDTLPLRDAFAVLFFVSVGMLFDPLIL-IQQPLAVL 306

Query: 279 LLLPI----KGVLYFWVIHQFHFRVRTSLLASLSLFNFSEFGLIVGGLAFKMGWI----N 330
             L I    K +  F+++  F    RT+L  + SL    EF  I+ GL   +  +     
Sbjct: 307 ATLAIILFGKSLAAFFLVRLFGHSQRTALTIAASLAQIGEFAFILAGLGMALNLLPQAGQ 366

Query: 331 SDILVALAVSVPLSFILAAPIERKGHAIYQRSAKWLKEQAAESLHTRDRLIDPGEA-QVL 389
           + +L    +S+ L+ +L A +E+     Y    + L+EQ  E     ++ I        L
Sbjct: 367 NLVLAGAILSIMLNPVLFALLEK-----YLAKTETLEEQTLEEAIEEEKQIPVDICNHAL 421

Query: 390 ILGMGRIGRGAYEELTSRHGEICLGVEIREEAANSHREEGRNVISGDATDPDFWERIFDT 449
           ++G GR+G    E+L +    + + +E      +  RE G   + G+A + +  + +   
Sbjct: 422 LVGYGRVGSLLGEKLLASDIPLVV-IETSRTRVDELRERGVRAVLGNAANEEIMQ-LAHL 479

Query: 450 GKVKLVLLAMPH-HQANQIALEQLQKRHYQGQIAAIAEYPDQIESLLEHGAH 500
              K ++L +P+ ++A +I +   + ++   +I A A Y D++  + E GA+
Sbjct: 480 ECAKWLILTIPNGYEAGEI-VASARAKNPDIEIIARAHYDDEVAYITERGAN 530