Pairwise Alignments

Query, 1297 a.a., phosphoribosylformylglycinamidine synthase from Vibrio cholerae E7946 ATCC 55056

Subject, 1228 a.a., Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain from Echinicola vietnamensis KMM 6221, DSM 17526

 Score =  680 bits (1754), Expect = 0.0
 Identities = 453/1279 (35%), Positives = 679/1279 (53%), Gaps = 96/1279 (7%)

Query: 41   DLKAELNPQELEKLEKLLTYGPTIQEHEPQGLLLLVTPRPGTISPWSSKATDIAHNCGLH 100
            + K  + P++L+KL  L      + + + +G      PR   I+PWS+ A +IA N G+ 
Sbjct: 17   EAKQPVAPEDLQKLSWLFGEADQLAQEKVEGSF--AGPRKEMITPWSTNAVEIAANMGIP 74

Query: 101  GIKRLERGTAYYVEAETALTAAQIATLEALLHDRMMEVVFAELTDAQQLFSV----AEPA 156
             I R+E         E +L        E    D M++  +  L   Q +F++     E  
Sbjct: 75   EILRIE---------EFSLLE------EGQKIDPMLQAKYPGLD--QDIFTIDLKPEEVL 117

Query: 157  PMSQVDVLAGGRRALEEANVSLGLALAEDEIDYLVESFTKLGRNPNDIELMMFAQANSEH 216
            P++ +          +  N   GLAL+++EI+YL +    L R   D E+  F+Q NSEH
Sbjct: 118  PITDI----------KSYNAQEGLALSDEEIEYLEKVSKSLSRPLTDSEVFGFSQVNSEH 167

Query: 217  CRHKIFNADWTIDGVKQDKSLFKMIKNTFEQTPDYVLSAYKDNAAVMTGSTVGRFFPDPE 276
            CRHKIFN  + IDG +++ +LF++IK T  + P+ ++SAYKDN A + G    +F P  +
Sbjct: 168  CRHKIFNGTFIIDGEEKENTLFQLIKKTSIKHPNKIVSAYKDNVAFVKGPKAQQFAPKSQ 227

Query: 277  SRQYTYHHE--DAHILMKVETHNHPTAISPWPGASTGSGGEIRDEGATGIGGKPKAGLVG 334
             +   +  +  D  + +K ETHN PT + P+ GA+TGSGGEIRD  A G    P AG   
Sbjct: 228  DKADYFQPQTIDTVLSLKAETHNFPTTVEPFNGAATGSGGEIRDRLAGGTASVPLAGTAV 287

Query: 335  FTTSNLRIPGFEQPWESDFGKPSRIVNA-LDIMLEGPLGGAAFNNEFGRPNLLGYFRTYE 393
            + TS  R     + WE D  +   +    +DI+++   G + F N+FG+P + G   T+E
Sbjct: 288  YMTSYSRSEA-GRSWEKDLKERKWLYQTPMDILIKASNGASDFGNKFGQPLISGSVLTFE 346

Query: 394  EKVTSHAGEEVRGYHKPIMIAGGMGNIRAEHIQKKEIPVGAKLIVLGGPAMNIGLGGGAA 453
             +      ++  G+ K IM+AGG+G  R ++  K     G K++++GG    IG+GG A 
Sbjct: 347  HE----ENDKQFGFDKVIMLAGGIGFTREKYSLKNTPVKGNKIVIMGGDNYRIGMGGSAV 402

Query: 454  SSMASGQSAEDLDFASVQRENPEMERRCQEVIDRCWQLGDKNPIAFIHDVGAGGISNALP 513
            SS+ +G+ +  ++  ++QR NPEM++R   VI R     D NPI  IHD GAGG  N L 
Sbjct: 403  SSVNTGEFSNSIELNAIQRSNPEMQKRVANVI-RAMAENDHNPIISIHDHGAGGHLNCLS 461

Query: 514  ELVNDGDRGGKFQLRNVPNDEPGMSPLEIWCNESQERYVLAVAAEDMPLFDAICQRERAP 573
            ELV D   GG   +  +P  +P +S  EI  NESQER  L +  E +     I +RERAP
Sbjct: 462  ELVED--TGGNIDIDKLPVGDPTLSAKEIIGNESQERMGLVIGKEHVETLKKISERERAP 519

Query: 574  YAVVGEATEERHLTLEDSHFANTPIDMPMDILLGKPPK--MHREASTLKVSSPALERSGI 631
            + VVGE T + H   E+ +    P+D  +  + G  PK  +  + +T+  + PA +   +
Sbjct: 520  FYVVGETTGDMHFKFENKNSGEKPVDWDLSHMFGSSPKTILTDKKTTVNYAEPAYKVDAL 579

Query: 632  ELNEAVDRVLRLPAVAEKTFLITIGDRSVTGLVARDQMVGPWQVPVANCAVTAASFDSYH 691
            E    +  VL+L AVA K +L    DRSVTG VA  Q  G  QVP+ N AV A  F    
Sbjct: 580  E--HYIAEVLQLEAVACKDWLTNKVDRSVTGRVATQQTTGAIQVPLNNVAVMAIDFTGKK 637

Query: 692  GEAMSMGERTPVALLDFGASARLAVGEAITNIAATDIGE-LKRIKLSANWMSPAGHPGED 750
            G A S+G     AL D  A ++LA+ EA+TN+    I + L  + LSANWM PA + GE+
Sbjct: 638  GIATSIGHAPVAALADPEAGSKLAIAEALTNLVWAPIEDGLSGVSLSANWMWPAKNEGEN 697

Query: 751  AGLYEAVKAVGEELCPALGITIPVGKDSMSMKTKWQENGEQKEVTSPLSLIITAFARVED 810
              LY AV+AV +     LGI IP GKDS+SM  K+ +    K V SP ++II++     D
Sbjct: 698  DRLYRAVQAVSD-FAIDLGINIPTGKDSLSMTQKYPDG---KTVYSPGTVIISSVGECAD 753

Query: 811  IRKTVTPQLRTDLGETSLILIDLGNGQNRLGATALAQVYKQLGDKPADVDNAAQLKGFFD 870
            IRKTVTP L+  +G T ++ ID      +LG ++ AQV  ++G  P  V ++      F 
Sbjct: 754  IRKTVTPDLKPAVG-TEILYIDFSRDSAQLGGSSFAQVVNKIGSTPPTVKDSTYFAKAFM 812

Query: 871  AVQTLVRNDKLVAYHDKGDGGLLVTLAEMAF-AGHCGIKANIETLGD-DALAALFNEELG 928
            AVQ L+    L++ HD   GGL+  L EMAF    CG+K N + L + D + ALF E  G
Sbjct: 813  AVQQLIGKGMLLSGHDISSGGLITALLEMAFPTQECGLKINTDQLAEKDIIKALFAENPG 872

Query: 929  AVVQVKNDELNAVLATLAAHGLEACAHVIGEVEASDRLLITCGEEVLIERSRTELRTIWA 988
             V+Q K  E  AV ATL   G+   A  +GEV A  ++ +  G+ + ++ +  E R  W 
Sbjct: 873  VVIQAK--EAKAVKATLDELGISYIA--LGEVTADSKITLE-GQGLSLDVA--EHRDTWF 925

Query: 989  EMTHKMQALRDNSACADQEFAAKQDNRDP---GLNAKLTYDVQADVAAPYIAKGVRPKMA 1045
              +  +   +     A + F   +        G + + TYD  A    P+       K A
Sbjct: 926  RSSFLLDQKQSGKKLAKERFENYKHQALDFTFGKDWEGTYD--AFKLNPFRHDASGTKAA 983

Query: 1046 ILREQGVNSHVEMAAAFDRAGFDAVDVHMSDILTGQTVLDAYQGLVACGGFSYGDVLGAG 1105
            I+RE+GVN   EMA A   AGFD  DVHM+D++ G+  L+    +V  GGFS  DVLG+ 
Sbjct: 984  IIREKGVNGDREMAYALWLAGFDVKDVHMTDLIAGRETLEDVNMIVFVGGFSNSDVLGSA 1043

Query: 1106 EGWAKSILFNAQAREQFEQFFQRKDTFSLGVCNGCQMLSNLRDLIPGAELWPRFVRNESD 1165
            +GWA + L+N +A+   ++F+ R DT SLGVCNGCQ++  L  +    ++ P+ + NES 
Sbjct: 1044 KGWAGAFLYNEKAKTALDKFYARPDTLSLGVCNGCQLMIELGLINRDHDVKPKMLHNESH 1103

Query: 1166 RFEARFSLVEVQKSPSLFFSEMAGSRMPIAVSHGEGRVEVRDAQHLAAIEQSGTVAIRFV 1225
            +FE+ F  V++ ++ ++ F  ++G R+ + V+HGEG+        L   +++  + +++ 
Sbjct: 1104 KFESAFVNVDIPENNTVMFGSLSGQRLGVWVAHGEGKFS------LPKDQEAYNIGMKY- 1156

Query: 1226 DNFGQPTQAYPSNPNGSPNAITGLTTQDGRVTIMMPHPERVFRTVANSWHPDNW------ 1279
                   QAYP NPNGS +A+ GL ++DGR   +MPH ER       S  P NW      
Sbjct: 1157 -----SYQAYPGNPNGSDHAVAGLASRDGRHLAIMPHIER-------SLAPWNWPHYPSD 1204

Query: 1280 ---GENGAWMRMFQNARKY 1295
                E   W+  F NA+++
Sbjct: 1205 LKDQEITPWVEAFVNAKEW 1223