Pairwise Alignments

Query, 949 a.a., isoleucine--tRNA ligase from Vibrio cholerae E7946 ATCC 55056

Subject, 959 a.a., Valyl-tRNA synthetase (EC 6.1.1.9) from Variovorax sp. SCN45

 Score =  181 bits (459), Expect = 2e-49
 Identities = 188/835 (22%), Positives = 332/835 (39%), Gaps = 174/835 (20%)

Query: 26  PEMLQRWYQEDLYGAIRQAKKGKKSFVLHDGPPYANGDIHIGHALNKILKDVIIKSKTLS 85
           PE  +R Y +  +   +Q K+G +SF +   PP   G +H+GHA N+ + D + +   + 
Sbjct: 31  PEWEKRGYAKAGFRGTQQPKEGAESFAIQLPPPNVTGTLHMGHAFNQTIMDSLTRYHRMK 90

Query: 86  GFDAPYIPGWDCHGLPIELMVEKKVGKPGQKVTAAEFREK---CREYAAGQVEGQ--KES 140
           G +  ++PG D  G+  +++VE+++ +  QKV+  E   K    R +   +  G    + 
Sbjct: 91  GANTLWVPGTDHAGIATQIVVERQLQE--QKVSRHELGRKNFVARVWEWKEKSGNTITQQ 148

Query: 141 FKRLGILGEWDKPYRTMDFVTEANIIRALGKIADNGHLLKGFKPVHWCTDCGSALAEAEV 200
            +R+G   +W + Y TMD      +++   K+ + G + +G +  +W     +++++ EV
Sbjct: 149 MRRMGDTVDWSREYFTMDDDLSKVVMQTFVKLYEEGLIYRGKRLGNWDPVLKTSVSDLEV 208

Query: 201 EYKNKVSPSIDVRFKAADEAAVLAKFGLAAGHEGKGDVSIVIWTTTPWTLPANRAVCLRA 260
           E              + +E   L        +   G  ++ + TT P T+  + A     
Sbjct: 209 E--------------SEEEDGFLWHLSYPLEN---GSGALTVATTRPETMLGDTA----- 246

Query: 261 DLEYVLIQVEGEQPERIIVASELAKSVMDRAGIEHFHNLGFATGADLELVQFQHPFYSFT 320
               V++  E E+ + +I                         G  ++L     P     
Sbjct: 247 ----VMVHPEDERYKHLI-------------------------GQRVKL-----PLVGRL 272

Query: 321 VPAILGDHVTTDSGTGVVHTAPGHGQEDFAVGQQYGLEVANPVGSNGVYLPDT-ELFAGQ 379
           +P I  D+V  + GTGVV   P H   D+AVGQ++ LE+   +  +     +  E + G 
Sbjct: 273 IPIIADDYVDKEFGTGVVKVTPAHDYNDYAVGQRHKLEMIGVLTLDATINDNAPEKYRGM 332

Query: 380 HVFKANDSVLEVLKEKGALLHHHAYEHSYPHCWRHKTPIIFRATPQWFVSMEQAG----- 434
             F A  +V+  L   G L+    ++   P C R    +    T QW+V+M + G     
Sbjct: 333 DRFVARKAVVADLDALGLLVEVKKHKLMVPRCARSGAIVEPMLTDQWYVAMTRPGADGQS 392

Query: 435 LREQALTAIKG--VHWMPDWGQSRIEGMVAGRPEWCISRQRTWGVPIALFVHKETAELHP 492
           + ++A+  +K   V ++P+   +     +    +W ISRQ  WG       H+       
Sbjct: 393 IAQKAIDVVKSGEVRFVPENWVNTYNHWMENIQDWTISRQLWWG-------HQ------- 438

Query: 493 NSADLIEKVAQLVEQKGIQAWWDLDTAELLGAEDAANYEKV--------LDTLDVWFDSG 544
                            I AW+D +    +  ++AA   K          D LD W+ S 
Sbjct: 439 -----------------IPAWYDEEGNVYVAQDEAAAQAKAPGKTLTRDEDVLDTWYSSA 481

Query: 545 VTHSAVVDARQEFNGAE----ADMYLEGSDQHRGWFQSSLISSVAMKGKAPYKEVLTHGF 600
           +   + +   ++    E    + + + G D    W    ++ +    GK P+++V  HG 
Sbjct: 482 LVPFSSLGWPEKTKDLELYLPSTVLVTGYDIIFFWVARMIMMTKHFTGKVPFRDVYIHGL 541

Query: 601 VVDGQGRKMSKSIGNVVAPQDVTNKL---------------------------------- 626
           V D QG+KMSKS GNV+ P D+ + +                                  
Sbjct: 542 VRDAQGKKMSKSEGNVLDPVDLIDGIALPELLDKRSQGLRKPETAPTVRKNTQKEFPEGI 601

Query: 627 ---GADILRLWVASTDYTGEVAVSDEILKRSADAYR----RIRNTARFFLANLNGFNPTT 679
              GAD LR   AS    G     D    +  + YR    ++ N  RF L N  G +   
Sbjct: 602 PAFGADALRFTFASLASLGRSINFD---SKRCEGYRNFCNKLWNATRFVLMNCEGQDCGL 658

Query: 680 DIIPVED------------MVALDRWAVGRALAAQQEIIQAYQDYNLHAVVQRLMNFCSI 727
                ED                D W V +    + E+ + + +Y L  V   +  F   
Sbjct: 659 LEHTKEDCKVGGPAHGYLKFSRADYWIVSQLQRVEAEVTKGFDEYRLDNVANTIYQFAWD 718

Query: 728 EMGSFYLDVIKDRQYTAKRGGHAQ-RSCQTALFFIVEALVRWMAPIMSFTADEIW 781
           E   +YL++ K +  T   G  AQ R+ +  L  ++E L+R   P++ F  +E+W
Sbjct: 719 EFCDWYLEIAKVQIQT---GDDAQKRATRRTLIRVLETLLRLAHPVIPFITEELW 770