Pairwise Alignments

Query, 1226 a.a., methionine synthase from Vibrio cholerae E7946 ATCC 55056

Subject, 1235 a.a., cobalamin-dependent methionine synthase from Pseudomonas putida KT2440

 Score = 1597 bits (4136), Expect = 0.0
 Identities = 805/1227 (65%), Positives = 979/1227 (79%), Gaps = 13/1227 (1%)

Query: 7    QQLEQQLKQRILLIDGGMGTMIQSYKLQEEDYRGARFVDWHCDLKGNNDLLVLTQPQIIK 66
            Q L+  LK+RIL++DGGMGTMIQSY+L+E DYRG RF DW  D+KGNNDLL+L++P +I 
Sbjct: 9    QALQNALKERILILDGGMGTMIQSYRLEEHDYRGTRFADWPSDVKGNNDLLLLSRPDVIA 68

Query: 67   EIHSAYLEAGADILETNTFNSTTIAMADYDMQSLSAEINFAAAKLAREVADEWTAKDPSR 126
             I  AYL+AGADILETNTFN+T I+ ADY M+SL  E+N   A++AR+VAD  T + P +
Sbjct: 69   AIEKAYLDAGADILETNTFNATQISQADYGMESLVYELNVEGARIARQVADAKTLETPDK 128

Query: 127  PRYVAGVLGPTNRTCSISPDVNDPGFRNVTFDGLVEAYSESTRALIKGGSDLILIETIFD 186
            PR+VAGVLGPT+RTCSISPDVNDPGFRNVTFD LVE Y E+TR LI+GG+DLILIETIFD
Sbjct: 129  PRFVAGVLGPTSRTCSISPDVNDPGFRNVTFDELVENYIEATRGLIEGGADLILIETIFD 188

Query: 187  TLNAKACAFAVDSVFEELGISLPVMISGTITDASGRTLSGQTTEAFYNALRHVRPISFGL 246
            TLNAKA  FAV  VFE+  + LP+MISGTITDASGRTLSGQTTEAF+N++RH +PIS GL
Sbjct: 189  TLNAKAAIFAVQQVFEDDNVELPIMISGTITDASGRTLSGQTTEAFWNSVRHAKPISVGL 248

Query: 247  NCALGPDELRQYVEELSRISECYVSAHPNAGLPNAFGEYDLSAEEMAEHIAEWAQAGFLN 306
            NCALG  +LR Y+EEL+  ++ +VSAHPNAGLPNAFGEYD +  EMA  + E+A +GFLN
Sbjct: 249  NCALGAKDLRPYLEELATKADTHVSAHPNAGLPNAFGEYDETPAEMAAVVEEFAASGFLN 308

Query: 307  LVGGCCGTTPEHIAAIAKAVEGVKPRALPDLKVECRLSGLEPLNIGPETLFVNVGERTNV 366
            ++GGCCGTTP HI AIA+AV   KPR +P++   CRLSGLEP  I  ++LFVNVGERTN+
Sbjct: 309  IIGGCCGTTPGHIQAIAEAVAKYKPREIPEIAKACRLSGLEPFTIDRQSLFVNVGERTNI 368

Query: 367  TGSARFKRLIKEEQYDEALDVAREQVENGAQIIDINMDEGMLDAEACMVRFLNLCASEPE 426
            TGSA+F RLI+EE Y EAL+VA +QVE GAQ+IDINMDEGMLD++A MVRFLNL A EP+
Sbjct: 369  TGSAKFARLIREENYTEALEVALQQVEAGAQVIDINMDEGMLDSQAAMVRFLNLIAGEPD 428

Query: 427  ISKVPVMVDSSKWEVIEAGLKCIQGKGIVNSISLKEGKEKFIAQAKLVRRYGAAVIVMAF 486
            IS+VP+M+DSSKWEVIEAGLKCIQGKGIVNSIS+KEG E+F   A+L +RYGAAV+VMAF
Sbjct: 429  ISRVPIMIDSSKWEVIEAGLKCIQGKGIVNSISMKEGVEQFKHHARLCKRYGAAVVVMAF 488

Query: 487  DEVGQADTRERKLEICRRAYHILVDEVGFPPEDIIFDPNIFAVATGIDEHNNYALDFINA 546
            DEVGQADT  RK EIC+R+Y ILV+EVGFPPEDIIFDPNIFAVATGI+EHNNYA+DFI A
Sbjct: 489  DEVGQADTAARKKEICQRSYDILVNEVGFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEA 548

Query: 547  VADIKRELPHAMISGGVSNVSFSFRGNNYVREAIHAVFLYHCFKHGMDMGIVNAGQLEIY 606
             A I+  LPHA+ SGGVSNVSFSFRGNN VREAIH+VFLYH  ++G+ MGIVNAGQLEIY
Sbjct: 549  CAYIRDHLPHALSSGGVSNVSFSFRGNNPVREAIHSVFLYHAIQNGLTMGIVNAGQLEIY 608

Query: 607  DNVPLKLREAVEDVILNRRSDGTERLLEIAEAYRENSVGKEEDASALEWRAWPVAKRLEH 666
            D +P +LRE VEDV+LNR   GT+ LL IA+ Y+     KE +    EWR+ PV KRLEH
Sbjct: 609  DEIPAQLREKVEDVVLNRTPHGTDALLAIADDYKGGGATKEVENE--EWRSLPVEKRLEH 666

Query: 667  ALVKGITEFIVQDTEEARQQASKPLEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVM 726
            ALVKGIT FIV+DTE  RQQ ++P+EVIEGPLM+GMNVVGDLFG GKMFLPQVVKSARVM
Sbjct: 667  ALVKGITAFIVEDTEACRQQCARPIEVIEGPLMNGMNVVGDLFGAGKMFLPQVVKSARVM 726

Query: 727  KQAVAYLEPFINAQKSGS-TSNGKILLATVKGDVHDIGKNIVGVVLQCNNFEIIDLGVMV 785
            KQAVA+L PFI A+K     + GKIL+ATVKGDVHDIGKNIVGVVL CN ++I+DLGVMV
Sbjct: 727  KQAVAHLIPFIEAEKGDKPEAKGKILMATVKGDVHDIGKNIVGVVLGCNGYDIVDLGVMV 786

Query: 786  PCEQILKVAREQNVDIIGLSGLITPSLDEMVHVAKEMERQGFELPLLIGGATTSKAHTAV 845
            P E+IL+ AREQ  DIIGLSGLITPSLDEMVHVA+EM+RQGFELPL+IGGATTSKAHTAV
Sbjct: 787  PAEKILQTAREQKCDIIGLSGLITPSLDEMVHVAREMQRQGFELPLMIGGATTSKAHTAV 846

Query: 846  KIEQNY-HAPVVYVNNASRAVGVCTSLLSDEQRPGFIERLDLDYERTRDQHARKTPKSRP 904
            KIE  Y +  V+YV +ASRAVGV T LLS E +PGF+E+  L+Y   R++ A ++ ++  
Sbjct: 847  KIEPKYSNDAVIYVTDASRAVGVATQLLSKELKPGFVEKTRLEYVDVRERTANRSARTER 906

Query: 905  VTLEQARANKAALDWANYTPPAPAKPGVHVFENIALATLRPYIDWTPFFMTWSLMGKYPA 964
            ++  QA A K   DWA Y P AP+  GV V E+I L TL  YIDWTPFF++W L GK+P 
Sbjct: 907  LSYAQAIAAKPQYDWAGYQPTAPSFTGVKVLEDIDLRTLAEYIDWTPFFISWDLAGKFPR 966

Query: 965  ILEHEEVGEEAKRLFHDANALLDKVEREGLLKASGMCALFPAASV-GDDIEVYSDESRTQ 1023
            IL  E VGE A  L+ DA  +LDK+  E L+ A  +   +PA  V  DDIEVY ++   Q
Sbjct: 967  ILTDEVVGEAATALYKDAREMLDKLIDEKLISARAVFGFWPANQVDDDDIEVYGEDG--Q 1024

Query: 1024 VAHVLYNLRQQTEKPKG-ANYCLSDYVAPKESGKRDWIGAFAVTGGIGERALADAYKAQG 1082
                L++LRQQT KP G  N+ L+D+VAPK+SG  D++G F  T GIG   +A AY+ +G
Sbjct: 1025 ALATLHHLRQQTIKPDGKPNWSLADFVAPKDSGVTDYVGGFITTAGIGAEEVAKAYQDKG 1084

Query: 1083 DDYNAIMIQAVADRLAEAFAEYLHEKVRKEIWGYASDENLSNDDLIRERYQGIRPAPGYP 1142
            DDY++IM++A+ADRLAEA AE+LHE+VRKE WGYA DE+L N+ LI+E+Y GIRPAPGYP
Sbjct: 1085 DDYSSIMVKALADRLAEACAEWLHEQVRKEHWGYARDEHLDNEALIKEQYSGIRPAPGYP 1144

Query: 1143 ACPEHTEKATLWQMLN---VEET--IGMSLTTSYAMWPGASVSGWYFSHPDSRYFAVAQI 1197
            ACP+HTEK TL+++L+   + ET   G+ LT  +AM+P A+VSGWYF+HP ++YFAV ++
Sbjct: 1145 ACPDHTEKETLFRLLDGTAIGETGPSGVYLTEHFAMFPAAAVSGWYFAHPQAKYFAVGKV 1204

Query: 1198 QPDQLHSYAERKGWRLEEAEKWLAPNL 1224
              DQ+  Y+ RKG  +  +E+WLAPNL
Sbjct: 1205 DKDQIERYSARKGQDISVSERWLAPNL 1231