Pairwise Alignments

Query, 1226 a.a., methionine synthase from Vibrio cholerae E7946 ATCC 55056

Subject, 898 a.a., 5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) from Hydrogenophaga sp. GW460-11-11-14-LB1

 Score = 1044 bits (2699), Expect = 0.0
 Identities = 542/904 (59%), Positives = 677/904 (74%), Gaps = 30/904 (3%)

Query: 343  LSGLEPLNIGPETLFVNVGERTNVTGSARFKRLIKEEQYDEALDVAREQVENGAQIIDIN 402
            LSGLEPL + P +LFVNVGERTNVTGS  F R+I E ++++AL VAR+QVENGAQIID+N
Sbjct: 3    LSGLEPLRVEPGSLFVNVGERTNVTGSKAFARMILEGRFEDALAVARQQVENGAQIIDVN 62

Query: 403  MDEGMLDAEACMVRFLNLCASEPEISKVPVMVDSSKWEVIEAGLKCIQGKGIVNSISLKE 462
            MDE MLD++A MVRFLNL A EP+I++VPVMVDSSKWEVIEAGL+C+QGKG+VNSIS+KE
Sbjct: 63   MDEAMLDSKAAMVRFLNLIAGEPDIARVPVMVDSSKWEVIEAGLRCVQGKGVVNSISMKE 122

Query: 463  GKEKFIAQAKLVRRYGAAVIVMAFDEVGQADTRERKLEICRRAYHILVDEVGFPPEDIIF 522
            G ++F  QA+LV+RYGAA +VMAFDE GQADT ERK+EIC RAY +LVDEVGFPPEDIIF
Sbjct: 123  GLDEFKRQARLVKRYGAAAVVMAFDEKGQADTYERKVEICERAYRVLVDEVGFPPEDIIF 182

Query: 523  DPNIFAVATGIDEHNNYALDFINAVADIKRELPHAMISGGVSNVSFSFRGNNYVREAIHA 582
            DPNIFA+ATGI+EHNNYA+DFINA   IK+ LP A +SGGVSNVSFSFRGN+ VREAIH 
Sbjct: 183  DPNIFAIATGIEEHNNYAVDFINATRWIKQNLPGAKVSGGVSNVSFSFRGNDPVREAIHT 242

Query: 583  VFLYHCFKHGMDMGIVNAGQLEIYDNVPLKLREAVEDVILNRRSDGTERLLEIAEAYREN 642
            VFLYH  K GMDMGIVNAG + +YD + L+LRE VEDV+LNRR D  ERL+E+AE+ + +
Sbjct: 243  VFLYHAIKAGMDMGIVNAGMVGVYDELELELRERVEDVVLNRRPDAGERLVEVAESAKGS 302

Query: 643  SVGKEEDASALEWRAWPVAKRLEHALVKGITEFIVQDTEEARQQ----ASKPLEVIEGPL 698
            +   ++D+   EWRA P+ +RL HALV+GI +FI +DTEE  ++      +PL VIEGPL
Sbjct: 303  A---KDDSKKNEWRALPIRERLSHALVRGINDFITEDTEEMWREIEAGGGRPLNVIEGPL 359

Query: 699  MDGMNVVGDLFGEGKMFLPQVVKSARVMKQAVAYLEPFINAQKSGSTS-------NGKIL 751
            MDGMNVVGDLFG+GKMFLPQVVKSARVMKQAVA+L P+I A+K    +        GKI+
Sbjct: 360  MDGMNVVGDLFGQGKMFLPQVVKSARVMKQAVAHLLPYIEAEKLALQAAGGDVKPKGKIV 419

Query: 752  LATVKGDVHDIGKNIVGVVLQCNNFEIIDLGVMVPCEQILKVAREQNVDIIGLSGLITPS 811
            +ATVKGDVHDIGKNIV VVLQCNN+E++++GVMVPC +IL +A+ +  DI+GLSGLITPS
Sbjct: 420  IATVKGDVHDIGKNIVTVVLQCNNYEVVNMGVMVPCHEILAMAKAEGADIVGLSGLITPS 479

Query: 812  LDEMVHVAKEMER----QGFELPLLIGGATTSKAHTAVKIEQNYHAPVVYVNNASRAVGV 867
            L+EM +VA EM++    +G  +PLLIGGATTS+ HTAVKI  +Y  PVVYV +ASR+V V
Sbjct: 480  LEEMQYVAGEMQKDEHFRGKGIPLLIGGATTSRVHTAVKIAPHYDGPVVYVPDASRSVSV 539

Query: 868  CTSLLSDEQRPGFIERLDLDYERTRDQHARKTPKSRPV-TLEQARANKAALDWANYTPPA 926
               LLSD Q   +I  ++ DYER R QHA K  K  P+  LE+AR NK  +DW  YTP  
Sbjct: 540  AQGLLSD-QAAAYIAEVNADYERVRTQHANK--KQVPLWPLERARLNKTPIDWKAYTPQK 596

Query: 927  PAKPGVHVFENIALATLRPYIDWTPFFMTWSLMGKYPAILEHEEVGEEAKRLFHDANALL 986
            P   G  VF+N  L  +  YIDW PFF TW L G +P IL+ E VGEEA+R+F D   +L
Sbjct: 597  PKFIGKRVFKNFDLNEIAKYIDWGPFFQTWDLAGPFPEILKDEVVGEEARRVFSDGKRML 656

Query: 987  DKVEREGLLKASGMCALFPAASV-GDDIEVYSDESRTQVAHVLYNLRQQTEKPK-----G 1040
             ++     L AS +  L+PA +V  DDIE Y+DESRT VA   + LRQQ EK +      
Sbjct: 657  QRLIEGRWLSASAVVGLYPANTVHDDDIEXYTDESRTSVALTWHGLRQQAEKHEIDGVMR 716

Query: 1041 ANYCLSDYVAPKESGKRDWIGAFAVTGGIGERALADAYKAQGDDYNAIMIQAVADRLAEA 1100
             + CLSD+VAP+ +   D++G FAVT G+G       +    DDY+AIM++A+ADR+AEA
Sbjct: 717  PSRCLSDFVAPRGAAD-DYVGMFAVTAGLGVEKKEKQFLDDLDDYSAIMLKALADRMAEA 775

Query: 1101 FAEYLHEKVRKEIWGYASDENLSNDDLIRERYQGIRPAPGYPACPEHTEKATLWQMLNVE 1160
             AE +H +VR ++WGY +DE LSN++LI+E+YQGIRPAPGYPACP+H+ K  ++ +L  E
Sbjct: 776  LAECMHHRVRTDLWGYVADEALSNEELIKEKYQGIRPAPGYPACPDHSVKRAMFDVLQCE 835

Query: 1161 ETIGMSLTTSYAMWPGASVSGWYFSHPDSRYFAVAQIQPDQLHSYAERKGWRLEEAEKWL 1220
            + IGM LT S AM P ASVSG+Y +HP S YF V +I  DQ+   AER      E ++WL
Sbjct: 836  D-IGMGLTESLAMTPAASVSGFYLAHPQSTYFNVGKIGDDQVDDLAERSAVARNELQRWL 894

Query: 1221 APNL 1224
            APNL
Sbjct: 895  APNL 898