Pairwise Alignments

Query, 1226 a.a., methionine synthase from Vibrio cholerae E7946 ATCC 55056

Subject, 1227 a.a., methionine synthase from Escherichia coli ECRC62

 Score = 1868 bits (4840), Expect = 0.0
 Identities = 918/1218 (75%), Positives = 1046/1218 (85%), Gaps = 1/1218 (0%)

Query: 7    QQLEQQLKQRILLIDGGMGTMIQSYKLQEEDYRGARFVDWHCDLKGNNDLLVLTQPQIIK 66
            +QL  QL +RIL++DGGMGTMIQSY+L E D+RG RF DW CDLKGNNDLLVL++P++I 
Sbjct: 6    EQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIA 65

Query: 67   EIHSAYLEAGADILETNTFNSTTIAMADYDMQSLSAEINFAAAKLAREVADEWTAKDPSR 126
             IH+AY EAGADI+ETNTFNSTTIAMADY M+SLSAEINFAAAKLAR  ADEWTA+ P +
Sbjct: 66   AIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEK 125

Query: 127  PRYVAGVLGPTNRTCSISPDVNDPGFRNVTFDGLVEAYSESTRALIKGGSDLILIETIFD 186
            PRYVAGVLGPTNRT SISPDVNDP FRN+TFDGLV AY EST+AL++GG+DLILIET+FD
Sbjct: 126  PRYVAGVLGPTNRTASISPDVNDPAFRNITFDGLVAAYRESTKALVEGGADLILIETVFD 185

Query: 187  TLNAKACAFAVDSVFEELGISLPVMISGTITDASGRTLSGQTTEAFYNALRHVRPISFGL 246
            TLNAKA  FAV + FE LG+ LP+MISGTITDASGRTLSGQTTEAFYN+LRH   ++FGL
Sbjct: 186  TLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEALTFGL 245

Query: 247  NCALGPDELRQYVEELSRISECYVSAHPNAGLPNAFGEYDLSAEEMAEHIAEWAQAGFLN 306
            NCALGPDELRQYV+ELSRI+ECYV+AHPNAGLPNAFGEYDL A+ MA+ I EWAQAGFLN
Sbjct: 246  NCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQAGFLN 305

Query: 307  LVGGCCGTTPEHIAAIAKAVEGVKPRALPDLKVECRLSGLEPLNIGPETLFVNVGERTNV 366
            +VGGCCGTTP+HIAA+++AVEG+ PR LP++ V CRLSGLEPLNIG ++LFVNVGERTNV
Sbjct: 306  IVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGEDSLFVNVGERTNV 365

Query: 367  TGSARFKRLIKEEQYDEALDVAREQVENGAQIIDINMDEGMLDAEACMVRFLNLCASEPE 426
            TGSA+FKRLIKEE+Y EALDVAR+QVENGAQIIDINMDEGMLDAEA MVRFLNL A EP+
Sbjct: 366  TGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPD 425

Query: 427  ISKVPVMVDSSKWEVIEAGLKCIQGKGIVNSISLKEGKEKFIAQAKLVRRYGAAVIVMAF 486
            I++VP+M+DSSKW+VIE GLKCIQGKGIVNSIS+KEG + FI  AKL+RRYGAAV+VMAF
Sbjct: 426  IARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAF 485

Query: 487  DEVGQADTRERKLEICRRAYHILVDEVGFPPEDIIFDPNIFAVATGIDEHNNYALDFINA 546
            DE GQADTR RK+EICRRAY IL +EVGFPPEDIIFDPNIFAVATGI+EHNNYA DFI A
Sbjct: 486  DEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGA 545

Query: 547  VADIKRELPHAMISGGVSNVSFSFRGNNYVREAIHAVFLYHCFKHGMDMGIVNAGQLEIY 606
              DIKRELPHA+ISGGVSNVSFSFRGN+ VREAIHAVFLY+  ++GMDMGIVNAGQL IY
Sbjct: 546  CEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIY 605

Query: 607  DNVPLKLREAVEDVILNRRSDGTERLLEIAEAYRENSVGKEEDASALEWRAWPVAKRLEH 666
            D++P +LR+AVEDVILNRR DGTERLLE+AE YR +      +A   EWR+W V KRLE+
Sbjct: 606  DDLPAELRDAVEDVILNRRDDGTERLLELAEKYRGSKTDDTANAQQAEWRSWEVNKRLEY 665

Query: 667  ALVKGITEFIVQDTEEARQQASKPLEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVM 726
            +LVKGITEFI QDTEEARQQA++P+EVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVM
Sbjct: 666  SLVKGITEFIEQDTEEARQQATRPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVM 725

Query: 727  KQAVAYLEPFINAQKSGSTSNGKILLATVKGDVHDIGKNIVGVVLQCNNFEIIDLGVMVP 786
            KQAVAYLEPFI A K    +NGK+++ATVKGDVHDIGKNIVGVVLQCNN+EI+DLGVMVP
Sbjct: 726  KQAVAYLEPFIEASKEQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDLGVMVP 785

Query: 787  CEQILKVAREQNVDIIGLSGLITPSLDEMVHVAKEMERQGFELPLLIGGATTSKAHTAVK 846
             E+IL+ A+E N D+IGLSGLITPSLDEMV+VAKEMERQGF +PLLIGGATTSKAHTAVK
Sbjct: 786  AEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKAHTAVK 845

Query: 847  IEQNYHAPVVYVNNASRAVGVCTSLLSDEQRPGFIERLDLDYERTRDQHARKTPKSRPVT 906
            IEQNY  P VYV NASR VGV  +LLSD QR  F+ R   +YE  R QH RK P++ PVT
Sbjct: 846  IEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHGRKKPRTPPVT 905

Query: 907  LEQARANKAALDWANYTPPAPAKPGVHVFENIALATLRPYIDWTPFFMTWSLMGKYPAIL 966
            LE AR N  A DW  YTPP   + GV   E  ++ TLR YIDWTPFFMTWSL GKYP IL
Sbjct: 906  LEAARDNDFAFDWQAYTPPVAHRLGVQEVE-ASIETLRNYIDWTPFFMTWSLAGKYPRIL 964

Query: 967  EHEEVGEEAKRLFHDANALLDKVEREGLLKASGMCALFPAASVGDDIEVYSDESRTQVAH 1026
            E E VG EA+RLF DAN +LDK+  E  L   G+  LFPA  VGDDIE+Y DE+RT V +
Sbjct: 965  EDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIEIYRDETRTHVIN 1024

Query: 1027 VLYNLRQQTEKPKGANYCLSDYVAPKESGKRDWIGAFAVTGGIGERALADAYKAQGDDYN 1086
            V ++LRQQTEK   ANYCL+D+VAPK SGK D+IGAFAVTGG+ E ALADA++AQ DDYN
Sbjct: 1025 VSHHLRQQTEKTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQHDDYN 1084

Query: 1087 AIMIQAVADRLAEAFAEYLHEKVRKEIWGYASDENLSNDDLIRERYQGIRPAPGYPACPE 1146
             IM++A+ADRLAEAFAEYLHE+VRK  WGYA +ENLSN++LIRE YQGIRPAPGYPACPE
Sbjct: 1085 KIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPAPGYPACPE 1144

Query: 1147 HTEKATLWQMLNVEETIGMSLTTSYAMWPGASVSGWYFSHPDSRYFAVAQIQPDQLHSYA 1206
            HTEKAT+W++L VE+  GM LT S+AMWPGASVSGWYFSHPDS+Y+AVAQIQ DQ+  YA
Sbjct: 1145 HTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQVEDYA 1204

Query: 1207 ERKGWRLEEAEKWLAPNL 1224
             RKG  + E E+WLAPNL
Sbjct: 1205 RRKGMSVTEVERWLAPNL 1222