Pairwise Alignments

Query, 1036 a.a., multidrug resistance protein from Vibrio cholerae E7946 ATCC 55056

Subject, 1036 a.a., AcrB/AcrD/AcrF family protein from Vibrio cholerae E7946 ATCC 55056

 Score =  607 bits (1566), Expect = e-177
 Identities = 378/1045 (36%), Positives = 579/1045 (55%), Gaps = 21/1045 (2%)

Query: 1    MRFTDVFIKRPVLAVSISFLIVLLGLQAIFKMQVREYPEMTNTVITVSTGYYGASADLIQ 60
            M  +DV +KRPV A+ +S L+ + G+ +  K+ VRE P++ + V++VST Y GASA +I+
Sbjct: 1    MWLSDVSVKRPVAALVLSMLLCVFGVVSFTKLAVREMPDIESPVVSVSTRYQGASATIIE 60

Query: 61   GFITQPLEQAVAQADNIDFMTSQSVLGRSTITVTMKLNTDPNAALSDVLAKTNSVRSQLP 120
              IT  LE  +A    ID +TS S  G S ITVT +L  D N  +SD+       +  LP
Sbjct: 61   SQITSVLEDQLAGISGIDEITSVSRNGMSRITVTFELGYDLNTGVSDIRDAVARAQRSLP 120

Query: 121  KEAEDPTVTMSTGSTTAVLYIGFTSNELASSQITDYLERVVNPQLYAVNGVSSIDLYGGM 180
            +EA+DP V  + GS  A +YI  +S+E+  +Q+TDY+ERV+  +   ++GVSS+D+ GG+
Sbjct: 121  EEADDPQVFKNNGSGQASVYINLSSSEMDRTQLTDYIERVLLDRFSLISGVSSVDVSGGL 180

Query: 181  KYALRVWLDPAKMAALNLSAADVMSILNANNYQSATGQAIGEFVLYNGSADTQVSTVEDL 240
               + V + P  MA   ++ +D+   LN  N +S  GQ   +  + +        + ED 
Sbjct: 181  YKVMYVRIKPELMAGRGVATSDISDALNKENLESPGGQVRNDSTVMSVRTARGYQSAEDF 240

Query: 241  ESLVVK-AEKGTVTRLGDIAKVTLAKSHDTYRASANGREAVVAAINAAPSANPINIAKDV 299
            E LVVK A  GT   L D+A V +   ++     ++G   V   I     ANP+ +AK V
Sbjct: 241  EYLVVKRASDGTPIYLKDVADVFIGAENENSTFKSDGIVNVSMGIVPQSDANPLEVAKRV 300

Query: 300  LEMLPELQKNMPSNIEMNVLYDSTVAINESIHEVIKTIVEAALIVLVVITLFLGSLRAVL 359
             E + ++Q+ +P    + + YDSTV I  SI EV  T+     +V++V+ +F+G LRA L
Sbjct: 301  HEEVDKVQQFLPKGTRLAIDYDSTVFIERSISEVYSTLFITGGLVILVLYIFIGQLRATL 360

Query: 360  IPIVTIPLSLIGVAMVMQMMGFSWNLMTLLAMVLAIGLVVDDAIVVLENVDRHIKEGESP 419
            IP VT+P+SLI   M     GFS NL+TL+A++L+IGLVVDDAIVV+EN+  HI+ GE P
Sbjct: 361  IPAVTVPVSLISAFMAAYYFGFSINLITLMALILSIGLVVDDAIVVVENIFHHIERGEKP 420

Query: 420  FRAAIIGTREIAIPVIAMTLTLGAVYAPIALMGGITGSLFKEFALTLAGSVFVSGIVALT 479
              AA  GTRE+   VIA TL L  V+ PI+ M G+ G LF EF++ LA +V  S ++ALT
Sbjct: 421  LLAAYKGTREVGFAVIATTLVLVMVFLPISFMDGMVGLLFTEFSVLLAMAVIFSSLIALT 480

Query: 480  LSPMMCSKMLKANEAPNKFELKVHHLLDRMTARYERMLTAVMAHR---PVVIAFAFIVFA 536
            L+P++ SK+LKAN  P +F   +  L  R+ + Y ++++  +  R   PVVIA       
Sbjct: 481  LTPVLGSKLLKANVKPGRFNQLIDRLFARLESGYRQVVSRAIRWRWAAPVVIA---ACIG 537

Query: 537  SLPMLFKFIPSELAPSEDKGVIMLMGTGPSNANLDYLANTMDDVNKILSDQPEVQFAQVF 596
                L + +P++L PSED+GVI     G    + + +A  MD V + L       F + F
Sbjct: 538  GSYGLMQLVPAQLTPSEDRGVIFSFVRGADATSYNRMAANMDLVEQRLMPLLGQGFLKSF 597

Query: 597  T-------GVPNSNQAFGIASMVPWSQREASQATVTNRVGTLVQDIPGMAVTAFQMPELP 649
            +       G       F I  +  W+ R  +     ++V   +  IP + V  F MP   
Sbjct: 598  SIQSPAFGGNAGDQTGFVIMILEDWNDRTVTAQEALSQVRKALAGIPDVRVFPF-MPGFR 656

Query: 650  GAGSGLPIQFVITTPSNFESLFTIATDVLTEVKANPMFVYSDLDLNFDSATMKINIDKDK 709
            G GS  P+QFV+   S++  L T A  +  E + +P    +D+D +  +  + + IDK +
Sbjct: 657  G-GSNEPVQFVL-GGSDYSELKTWAEKLEEEAEKSPFMTGADIDYSEKTPELVVTIDKQR 714

Query: 710  AGAYGVTMQDIGITLSTMMADGYVNRIDLNGRSYEVIPQVERKWRLNPESMNSYYVRAAD 769
            A   G++++ I  TL  M+    V      G  Y+V  + +     N   ++  Y+R A 
Sbjct: 715  AAELGISVKSISDTLEVMLGGKKVTTFVERGEEYDVYLRGDENSFNNAADLSQIYMRTAT 774

Query: 770  GKVIPLGSLVTIDVVAEPRSLPHFNQLNSATVGAVPAPGTAMGDAINWFENLASSKLPKG 829
            G+++ L ++  ID VA    L H+N+  S T+ A    G  +G A+++ +  A   LP  
Sbjct: 775  GELVTLDTVTRIDEVASAIRLAHYNKQKSVTITANLEAGYTLGQALDFLDQKAQEILPND 834

Query: 830  YSHDYMGEARQYVTEGSALYATFGLALAIIFLVLAIQFESLRDPLVIMVSVPLAICGALI 889
             S  Y GE++ +    S++   F LAL + +LVLA QFES  +PLV+M++VP+ + G  +
Sbjct: 835  ISVSYSGESKDFKENQSSVAIVFALALLVAYLVLAAQFESFINPLVVMLTVPMGVFGGFL 894

Query: 890  ALAWGTATMNIYSQVGLITLVGLITKHGILICEVAKEEQLHNKLSRIE-AVMHAAKVRLR 948
             L      MNIYSQ+G+I L+G++TK+GILI E A   QL ++    E A++ A+  RLR
Sbjct: 895  GLFVMGQGMNIYSQIGMIMLIGMVTKNGILIVEFA--NQLRDRGVEFEKAIIDASARRLR 952

Query: 949  PILMTTAAMIAGLIPLMYATGAGAAQRFSIGIVIVSGLAIGTLFTLFVLPVIYSYLAEKH 1008
            PILMT    +AG IPL+ +TGAG   R ++G VI  G+   TL TL V+P +Y  ++   
Sbjct: 953  PILMTAFTTLAGSIPLIVSTGAGYESRIAVGTVIFFGMGFATLVTLLVIPAMYRLISGST 1012

Query: 1009 KPLPVFVEDKDLEKLARIDEAKAAH 1033
            +  P  VE +   +L +  + +A H
Sbjct: 1013 Q-APGHVEAELNHELQQDVKGRAQH 1036