Pairwise Alignments

Query, 1036 a.a., multidrug resistance protein from Vibrio cholerae E7946 ATCC 55056

Subject, 1034 a.a., RND efflux system, inner membrane transporter from Sphingobium sp. HT1-2

 Score =  577 bits (1487), Expect = e-168
 Identities = 343/1018 (33%), Positives = 557/1018 (54%), Gaps = 18/1018 (1%)

Query: 1    MRFTDVFIKRPVLAVSISFLIVLLGLQAIFKMQVREYPEMTNTVITVSTGYYGASADLIQ 60
            M+ +D+ ++RPV +  ++ L+ ++GL   F + VREYP+    +++V T Y GA+A +++
Sbjct: 1    MQLSDLSVRRPVFSAVVAVLMCIVGLVGYFSLSVREYPDTDPPIVSVETTYTGAAASVVE 60

Query: 61   GFITQPLEQAVAQADNIDFMTSQSVLGRSTITVTMKLNTDPNAALSDVLAKTNSVRSQLP 120
              ITQ +E AVA    I  +TS S  G S I +    + D ++A +DV  +  SV   LP
Sbjct: 61   TRITQQIEDAVAGVQGIQTITSTSQDGTSNINIEFDPSRDIDSAANDVRDRVGSVTQDLP 120

Query: 121  KEAEDPTVTMSTGSTTAVLYIGFTSNELASSQITDYLERVVNPQLYAVNGVSSIDLYGGM 180
            ++A  P +        ++L++ F+    +  QI+DYL+R +  +  A++GV+ + + G  
Sbjct: 121  EDALAPEIRKVDSDARSILFLAFSRPGWSPIQISDYLDRNIADRFAAIDGVARVTIGGEA 180

Query: 181  KYALRVWLDPAKMAALNLSAADVMSILNANNYQSATGQAIGEFVLYNGSADTQVSTVEDL 240
            + + R+W +  K+AA  L+ ADV + L   N +   G+   +        +   +T +  
Sbjct: 181  RPSTRIWFNAEKLAAFGLTPADVEAALRTQNVELPAGRFESKDQNQTLRVERPFATPDQF 240

Query: 241  ESLVV-KAEKGTVTRLGDIAKVTLAKSHDTYRASANGREAVVAAINAAPSANPINIAKDV 299
              LVV + E G   +LGD+A++     +      +N   A+   I     AN + +A+  
Sbjct: 241  AQLVVGRGEDGYQVKLGDVARIEEGAENPYSSFRSNQGTAIGIGIIRQSGANTLEVAQKA 300

Query: 300  LEMLPELQKNMPSNIEMNVLYDSTVAINESIHEVIKTIVEAALIVLVVITLFLGSLRAVL 359
              ++ EL+  +P  +++ +  D ++ I  +I  V  T++EAAL+V++VI LFLGS+RA +
Sbjct: 301  KALIKELEPTLPKGMKVAIGTDESLFIERAIDNVYDTLIEAALLVILVIFLFLGSVRATI 360

Query: 360  IPIVTIPLSLIGVAMVMQMMGFSWNLMTLLAMVLAIGLVVDDAIVVLENVDRHIKEGESP 419
            +P VT+P+ L+    VM ++G S NL+TLLA VLAIGLVVDDAIVVLENV   +++G+ P
Sbjct: 361  VPAVTVPICLLATCAVMWLLGLSINLLTLLAFVLAIGLVVDDAIVVLENVYHRVEQGDDP 420

Query: 420  FRAAIIGTREIAIPVIAMTLTLGAVYAPIALMGGITGSLFKEFALTLAGSVFVSGIVALT 479
              AA +GTR++   +I+ TL + AV+ P+  + G TG LF+E A+ +  ++  SG ++L+
Sbjct: 421  LVAAYLGTRQVGFAIISTTLVVCAVFVPVMFLAGQTGLLFRELAIAMIAAIGFSGFISLS 480

Query: 480  LSPMMCSKMLKANEAPNKFELKVHHLLDRMTARYERMLTAVMAHRPVVIAFAFIVFASLP 539
            L+PM+CSK+LK N    +    V     R+   Y R L   +  +P++      +F  + 
Sbjct: 481  LAPMLCSKLLK-NAERGRLARWVDDRFQRIEHGYGRWLDWTL-KKPLMPLLGVAIFLGVA 538

Query: 540  -MLFKFIPSELAPSEDKGVIMLMGTGPSNANLDYLANTMDDVNKILS--------DQPEV 590
              LF  +P+ELAP+ED GV+      P     D +   M  +   L+            +
Sbjct: 539  FFLFTRLPAELAPAEDTGVVEANVNAPEGTGFDRMMAYMQKIENDLAFLRKDGTLQNLVI 598

Query: 591  QFAQVFTGVPNSNQAFGIASMVPWSQREASQATVTNRVGTLVQDIPGMAVTAFQMPELPG 650
            +    F    + N    IA + PW  R  + A V   +  ++ D PG+   A     L G
Sbjct: 599  RTPGGFGTTDDYNNGNVIAFLRPWEDRTITTAEVATIINKVIADQPGVRGNAAPRSGL-G 657

Query: 651  AGSGLPIQFVITTPSNFESLFTIATDVLTEVKANPMFVYSDLDLNFDSATMKINIDKDKA 710
             G GLP+  V+   S +E L      ++    + P  +  D D       M+I  D  +A
Sbjct: 658  RGRGLPVNIVL-AGSTYEGLVAARDRIMLAAASYPGLINLDSDYKETKPQMRIETDLQRA 716

Query: 711  GAYGVTMQDIGITLSTMMADGYVNRIDLNGRSYEVIPQVERKWRLNPESMNSYYVRAADG 770
            G  GV++ D+   L +++    V      G  Y V+ Q ER  R     +    VR+  G
Sbjct: 717  GDLGVSVNDVSQALQSLLGSRRVTTYVDRGEEYRVLVQAERDGRQTLADLERIQVRSRRG 776

Query: 771  KVIPLGSLVTIDVVAEPRSLPHFNQLNSATVGAVPAPGTAMGDAINWFENLASSKLPKGY 830
             ++PL ++VT+  VA PR L  +N+L + T+ A  APGT++G  + + E+ A    P+  
Sbjct: 777  VLVPLSAVVTVREVAGPRQLNRYNKLRAITLTAALAPGTSLGQGLAFLEDQARQS-PEVL 835

Query: 831  SHDYMGEARQYVTEGSALYATFGLALAIIFLVLAIQFESLRDPLVIMVSVPLAICGALIA 890
            +  Y GE++     G +++  FGL + I++L+LA QFES   P VI+ +VPLA+ G  + 
Sbjct: 836  AIGYRGESQSLRETGGSIWIVFGLTILIVYLLLAAQFESFIHPGVIIATVPLAVAGGALG 895

Query: 891  LAWGTATMNIYSQVGLITLVGLITKHGILICEVAKEEQLHNKLSRI-EAVMHAAKVRLRP 949
            LA    ++N+YSQ+G++ LVGL  K+GILI E A   QL ++   I EA+  AAK RLRP
Sbjct: 896  LAITGGSINLYSQIGIVMLVGLAAKNGILIVEFA--NQLRDEGMEIAEAIREAAKRRLRP 953

Query: 950  ILMTTAAMIAGLIPLMYATGAGAAQRFSIGIVIVSGLAIGTLFTLFVLPVIYSYLAEK 1007
            ILMT+ A + G +PL+   GAGAA R SIG+VIV G+++ TL TLF++P+ YS +A++
Sbjct: 954  ILMTSIATVIGAVPLVLRGGAGAAARHSIGVVIVFGVSLATLITLFLIPIFYSRVAKR 1011



 Score = 62.0 bits (149), Expect = 2e-13
 Identities = 69/338 (20%), Positives = 136/338 (40%), Gaps = 19/338 (5%)

Query: 177  YGGMKYALRVWLDPAKMAALNLSAADV----MSILNANNYQSATGQAIGEFVLYNGSADT 232
            Y   K  +R+  D  +   L +S  DV     S+L +    +   +     VL     D 
Sbjct: 700  YKETKPQMRIETDLQRAGDLGVSVNDVSQALQSLLGSRRVTTYVDRGEEYRVLVQAERDG 759

Query: 233  QVSTVEDLESLVVKAEKGTVTRLGDIAKVTLAKSHDTYRASANGREAVVAAINAAPSANP 292
            +  T+ DLE + V++ +G +  L  +  V      +        R   + AI    +  P
Sbjct: 760  R-QTLADLERIQVRSRRGVLVPLSAVVTV-----REVAGPRQLNRYNKLRAITLTAALAP 813

Query: 293  INIAKDVLEMLPELQKNMPSNIEMNVLYDSTVAINESIHEVIKTI-VEAALIVLVVITLF 351
                   L  L +  +  P  + +    +S     +S+ E   +I +   L +L+V  L 
Sbjct: 814  GTSLGQGLAFLEDQARQSPEVLAIGYRGES-----QSLRETGGSIWIVFGLTILIVYLLL 868

Query: 352  LGSLRAVLIP---IVTIPLSLIGVAMVMQMMGFSWNLMTLLAMVLAIGLVVDDAIVVLEN 408
                 + + P   I T+PL++ G A+ + + G S NL + + +V+ +GL   + I+++E 
Sbjct: 869  AAQFESFIHPGVIIATVPLAVAGGALGLAITGGSINLYSQIGIVMLVGLAAKNGILIVEF 928

Query: 409  VDRHIKEGESPFRAAIIGTREIAIPVIAMTLTLGAVYAPIALMGGITGSLFKEFALTLAG 468
             ++   EG     A     +    P++  ++       P+ L GG   +      + +  
Sbjct: 929  ANQLRDEGMEIAEAIREAAKRRLRPILMTSIATVIGAVPLVLRGGAGAAARHSIGVVIVF 988

Query: 469  SVFVSGIVALTLSPMMCSKMLKANEAPNKFELKVHHLL 506
             V ++ ++ L L P+  S++ K   +P     K+   L
Sbjct: 989  GVSLATLITLFLIPIFYSRVAKRTVSPQTVGRKLDSAL 1026