Pairwise Alignments

Query, 1036 a.a., multidrug resistance protein from Vibrio cholerae E7946 ATCC 55056

Subject, 1059 a.a., Multidrug efflux RND transporter MexF from Pseudomonas putida KT2440

 Score =  528 bits (1359), Expect = e-153
 Identities = 338/1042 (32%), Positives = 552/1042 (52%), Gaps = 49/1042 (4%)

Query: 1    MRFTDVFIKRPVLAVSISFLIVLLGLQAIFKMQVREYPEMTNTVITVSTGYYGASADLIQ 60
            M F+  FI RP+ A  +S ++++ G  ++F++ + EYPE+    + V   + GA+  +I 
Sbjct: 1    MNFSKFFITRPIFAAVLSLVLLIAGSISLFQLPISEYPEVVPPTVVVRANFPGANPKVIG 60

Query: 61   GFITQPLEQAVAQADNIDFMTSQSVL-GRSTITVTMKLNTDPNAALSDVLAKTNSVRSQL 119
              +  PLEQA+   +N+ +M+SQS   G+ T+T+T  L TD + A   V  +    + +L
Sbjct: 61   ETVAAPLEQAITGVENMLYMSSQSTADGKLTLTITFALGTDLDNAQVQVQNRVTRTQPKL 120

Query: 120  PKEAEDPTVTMSTGSTTAVLYIGFTS--NELASSQITDYLERVVNPQLYAVNGVSSIDLY 177
            P+E     +T+   S    + +  TS  N      +++Y    +  +L  + GV  + L+
Sbjct: 121  PEEVTRIGITVDKASPDLTMVVHLTSPDNRYDMLYLSNYAILNIKDELARLGGVGDVQLF 180

Query: 178  GGMKYALRVWLDPAKMAALNLSAADVMSILNANNYQSATGQ-----AIGEFVLYNGSADT 232
            G   Y+LRVWLDP K A+ NL+A+DV++ +   N Q A GQ     A G    +  S +T
Sbjct: 181  GMGDYSLRVWLDPNKTASRNLTASDVVAAIREQNRQVAAGQLGAPPAPGS-TSFQLSINT 239

Query: 233  QVSTV--EDLESLVVKA-EKGTVTRLGDIAKVTLAKSHDTYRASANGREAVVAAINAAPS 289
            Q   V  E+ E+++++A   G +TRL DIA+V L  S    R+  N + AV   I   P 
Sbjct: 240  QGRLVNEEEFENIIIRAGADGEITRLKDIARVELGSSQYALRSLLNNQPAVAIPIFQRPG 299

Query: 290  ANPINIAKDVLEMLPELQKNMPSNIEMNVLYDSTVAINESIHEVIKTIVEAALIVLVVIT 349
            +N I I+ +V   + EL+K+ P  ++ +++YD T+ +  SI  V+ T+ EA ++V++V+ 
Sbjct: 300  SNAIEISDEVRAKMAELKKDFPEGMDYSIVYDPTIFVRGSIEAVVHTLFEALVLVVLVVI 359

Query: 350  LFLGSLRAVLIPIVTIPLSLIGVAMVMQMMGFSWNLMTLLAMVLAIGLVVDDAIVVLENV 409
            LFL + RA +IP++ +P+SLIG   VM + GFS N ++L  +VLAIG+VVDDAIVV+ENV
Sbjct: 360  LFLQTWRASIIPLLAVPVSLIGTFAVMHLFGFSLNALSLFGLVLAIGIVVDDAIVVVENV 419

Query: 410  DRHIKEGESPFRAAIIGTREIAIPVIAMTLTLGAVYAPIALMGGITGSLFKEFALTLAGS 469
            +R+I  G  P  A      E+  P+IA  L L AV+ P A + G+TG  +K+FALT+A S
Sbjct: 420  ERNIGLGLKPLEATQKAMSEVTGPIIATALVLCAVFVPAAFISGLTGQFYKQFALTIAIS 479

Query: 470  VFVSGIVALTLSPMMCSKMLKANEAP-NKFELKVHHLL------------DRMTARYERM 516
              +S   +LTLSP + + +LK + AP ++F   +  LL            DR +  Y   
Sbjct: 480  TVISAFNSLTLSPALAAVLLKDHHAPKDRFSRFLDKLLGSWLFSPFNRFFDRASHSYVGG 539

Query: 517  LTAVMAHRPVVIAFAFIVFASLPML----FKFIPSELAPSEDKGVIMLMGTGPSNANLDY 572
            +  V+    +    A  V+A L  L    F   P+   P++DK  ++     P  A+LD 
Sbjct: 540  VRRVIRSSGI----ALFVYAGLMGLTYLGFSSTPTGFVPAQDKQYLVAFAQLPDAASLDR 595

Query: 573  LANTMDDVNKILSDQPEVQFAQVFTGV--------PNSNQAFGIASMVPWSQRE---ASQ 621
                +  +++I   QP V  +  F G+        PNS   F    + P+ +R+    S 
Sbjct: 596  TEAVIKRMSEIALKQPGVADSVAFPGLSINGFTNSPNSGIVF--TPLKPFDERKDPSQSA 653

Query: 622  ATVTNRVGTLVQDIPGMAVTAFQMPELPGAGS--GLPIQFVITTPSNFESLFTIATDVLT 679
            A +   +     DI    +  F  P + G G+  G  +Q        +E+L+    +++ 
Sbjct: 654  AAIAAALNAQFADIQDAYIAIFPPPPVQGLGTIGGFRLQIEDRGNLGYEALYKETQNIIA 713

Query: 680  EVKANPMFVYSDLDLNFDSATMKINIDKDKAGAYGVTMQDIGITLSTMMADGYVNRIDLN 739
            +    P           +   +   ID++KA  +GV + DI  TL   +   Y N  +  
Sbjct: 714  KSHNVPELAGLFTSYQVNVPQVDAAIDREKAKTHGVAITDIFDTLQVYLGSLYTNDFNRF 773

Query: 740  GRSYEVIPQVERKWRLNPESMNSYYVRAADGKVIPLGSLVTIDVVAEPRSLPHFNQLNSA 799
            GR+Y+V  Q E+++RL+ E +    VR   G++IPL + + +   + P  + H+N   +A
Sbjct: 774  GRTYQVNVQAEQQFRLDAEQIGQLKVRNNLGEMIPLATFLKVSDTSGPDRVMHYNGFITA 833

Query: 800  TVGAVPAPGTAMGDAINWFENLASSKLPKGYSHDYMGEARQYVTEGSALYATFGLALAII 859
             +    APG + G A    E L   +LP G + ++     Q +  G+     F L + + 
Sbjct: 834  EINGAAAPGYSSGQAEAAIEKLLKEELPNGMTFEWTDLTYQQILSGNTALLVFPLCVLLA 893

Query: 860  FLVLAIQFESLRDPLVIMVSVPLAICGALIALAWGTATMNIYSQVGLITLVGLITKHGIL 919
            FLVLA Q+ES   PL +++ VP+ +  A+  +       NI++Q+GLI LVGL  K+ IL
Sbjct: 894  FLVLAAQYESWSLPLAVILIVPMTLLSAITGVIVSGGDNNIFTQIGLIVLVGLACKNAIL 953

Query: 920  ICEVAKEEQLHNKLSRIEAVMHAAKVRLRPILMTTAAMIAGLIPLMYATGAGAAQRFSIG 979
            I E AK+EQ    L  + AV+ A ++RLRPILMT+ A I G++PL++++GAG+  R ++G
Sbjct: 954  IVEFAKDEQAKG-LDPLAAVLEACRLRLRPILMTSIAFIMGVVPLVFSSGAGSEMRHAMG 1012

Query: 980  IVIVSGLAIGTLFTLFVLPVIY 1001
            + + SG+   T+F LF+ PV +
Sbjct: 1013 VAVFSGMIGVTVFGLFLTPVFF 1034



 Score = 59.7 bits (143), Expect = 1e-12
 Identities = 84/451 (18%), Positives = 180/451 (39%), Gaps = 29/451 (6%)

Query: 582  KILSDQPEVQFAQVFTGVPN----SNQAFGIASMVPW------SQREASQATVTNRVGTL 631
            K++ +       Q  TGV N    S+Q+     +         +  + +Q  V NRV   
Sbjct: 57   KVIGETVAAPLEQAITGVENMLYMSSQSTADGKLTLTITFALGTDLDNAQVQVQNRVTRT 116

Query: 632  VQDIPGMAVTAFQMPELPGAGSGLPIQFVITTPSNFESLFTIATDVLTEVKANPMFV--Y 689
               +P   VT   +  +  A   L +   +T+P N   +  ++   +  +K     +   
Sbjct: 117  QPKLPE-EVTRIGIT-VDKASPDLTMVVHLTSPDNRYDMLYLSNYAILNIKDELARLGGV 174

Query: 690  SDLDL-NFDSATMKINIDKDKAGAYGVTMQDIGITL---STMMADGYVNRIDLNGRSYEV 745
             D+ L      ++++ +D +K  +  +T  D+   +   +  +A G +      G +   
Sbjct: 175  GDVQLFGMGDYSLRVWLDPNKTASRNLTASDVVAAIREQNRQVAAGQLGAPPAPGSTSFQ 234

Query: 746  IPQVERKWRLNPESMNSYYVRA-ADGKVIPLGSLVTIDVVAEPRSLPHFNQLNSATVGAV 804
            +    +   +N E   +  +RA ADG++  L  +  +++ +   +L     LN+    A+
Sbjct: 235  LSINTQGRLVNEEEFENIIIRAGADGEITRLKDIARVELGSSQYALRSL--LNNQPAVAI 292

Query: 805  PA---PGT---AMGDAINWFENLASSKLPKGYSHDYMGEARQYVTEG-SALYATFGLALA 857
            P    PG+    + D +           P+G  +  + +   +V     A+  T   AL 
Sbjct: 293  PIFQRPGSNAIEISDEVRAKMAELKKDFPEGMDYSIVYDPTIFVRGSIEAVVHTLFEALV 352

Query: 858  IIFLVLAIQFESLRDPLVIMVSVPLAICGALIALAWGTATMNIYSQVGLITLVGLITKHG 917
            ++ LV+ +  ++ R  ++ +++VP+++ G    +     ++N  S  GL+  +G++    
Sbjct: 353  LVVLVVILFLQTWRASIIPLLAVPVSLIGTFAVMHLFGFSLNALSLFGLVLAIGIVVDDA 412

Query: 918  ILICEVAKEEQLHNKLSRIEAVMHAAKVRLRPILMTTAAMIAGLIPLMYATGAGAAQRFS 977
            I++ E   E  +   L  +EA   A      PI+ T   + A  +P  + +G        
Sbjct: 413  IVVVENV-ERNIGLGLKPLEATQKAMSEVTGPIIATALVLCAVFVPAAFISGLTGQFYKQ 471

Query: 978  IGIVIVSGLAIGTLFTLFVLPVIYSYLAEKH 1008
              + I     I    +L + P + + L + H
Sbjct: 472  FALTIAISTVISAFNSLTLSPALAAVLLKDH 502