Pairwise Alignments

Query, 400 a.a., Bcr/CflA family drug resistance efflux transporter from Vibrio cholerae E7946 ATCC 55056

Subject, 394 a.a., 2-module integral membrane pump; multidrug resistance (VIMSS) from Escherichia coli BW25113

 Score =  138 bits (347), Expect = 3e-37
 Identities = 109/392 (27%), Positives = 179/392 (45%), Gaps = 10/392 (2%)

Query: 5   MPSQVSKQQMVLLTLLVLFSPLAIDIYLPALPQISQAFHVEHALAQDTITWFLFAMGVGQ 64
           M  Q +   +++L LLV    +A  IY+PA+  +++  +V     Q  +  +L   GV Q
Sbjct: 1   MKRQRNVNLLLMLVLLVAVGQMAQTIYIPAIADMARDLNVREGAVQSVMGAYLLTYGVSQ 60

Query: 65  LFAGPLADKYGRRTVALGGISIYALSALLAWSAQSIEWMLMARLLQGLGACATSVAAFAT 124
           LF GP++D+ GRR V L G+SI+ L+ L+A +  S+  ++ A  +QG+G     V A   
Sbjct: 61  LFYGPISDRVGRRPVILVGMSIFMLATLVAVTTSSLTVLIAASAMQGMGTGVGGVMARTL 120

Query: 125 VRDLFGPQRSGKMISYLNGAICFIPALAPILGSWLTQQFGWRANFSFMTGFALLVGLAMA 184
            RDL+   +     S LN  I   P LAP++G  L   + WRA + F+      V  +MA
Sbjct: 121 PRDLYERTQLRHANSLLNMGILVSPLLAPLIGGLLDTMWNWRACYLFLLVLCAGVTFSMA 180

Query: 185 LRLQESNPYMGSRPAVFKLSRYAAVLKAPTFLFHASLCLLAMAVILAYVTSAPVILMERL 244
             + E+ P     P    L+ Y  +     F  +  + +  +A I A+   + V++   L
Sbjct: 181 RWMPETRPV--DAPRTRLLTSYKTLFGNSGFNCYLLMLIGGLAGIAAFEACSGVLMGAVL 238

Query: 245 QLSMNEFTFWFGVNAVINIIACMTAPKVMDKLGTRWSLII--GITTLMIAGSLMLV--LR 300
            LS    +  F    ++ I A         +   R+S ++   +   ++AG LM +    
Sbjct: 239 GLSSMTVSILF----ILPIPAAFFGAWFAGRPNKRFSTLMWQSVICCLLAGLLMWIPDWF 294

Query: 301 NQASALAFMLPVFLSSIGFAWILGAAAGKALAPFGDKAGTAAALLGLFQMSGSGLLVGTL 360
              +    ++P  L   G   +   A   A+ PF   AGTA AL+G  Q  GSG+L    
Sbjct: 295 GVMNVWTLLVPAALFFFGAGMLFPLATSGAMEPFPFLAGTAGALVGGLQNIGSGVLASLS 354

Query: 361 QRIMPEPQLLIGLTMWLAAPALLILFSPLGFR 392
             +    Q  +GL M L    +++ + PL  R
Sbjct: 355 AMLPQTGQGSLGLLMTLMGLLIVLCWLPLATR 386