Pairwise Alignments

Query, 1182 a.a., 5-methyltetrahydrofolate--homocysteine methyltransferase (NCBI) from Rhodospirillum rubrum S1H

Subject, 1235 a.a., cobalamin-dependent methionine synthase from Pseudomonas putida KT2440

 Score =  534 bits (1376), Expect = e-155
 Identities = 402/1241 (32%), Positives = 609/1241 (49%), Gaps = 120/1241 (9%)

Query: 8    LRNRVLLCDGGMGSLVQAMDLSVDGDFMGR---------ENCTEVLNLSRPDVVRDIHTR 58
            L+ R+L+ DGGMG+++Q+  L  + D+ G          +   ++L LSRPDV+  I   
Sbjct: 15   LKERILILDGGMGTMIQSYRLE-EHDYRGTRFADWPSDVKGNNDLLLLSRPDVIAAIEKA 73

Query: 59   YFAAGADCVETNTFGGSTLTLAEFDLADRTREINRRAAEIAREAAESFA---DGRDRFVL 115
            Y  AGAD +ETNTF  + ++ A++ +     E+N   A IAR+ A++       + RFV 
Sbjct: 74   YLDAGADILETNTFNATQISQADYGMESLVYELNVEGARIARQVADAKTLETPDKPRFVA 133

Query: 116  GSIGPGTKL---------PSLGHIDYDTLKDAITVQCEGLIEGGADAILVETCQDPLQFK 166
            G +GP ++          P   ++ +D L +       GLIEGGAD IL+ET  D L  K
Sbjct: 134  GVLGPTSRTCSISPDVNDPGFRNVTFDELVENYIEATRGLIEGGADLILIETIFDTLNAK 193

Query: 167  AAINAAKAARLALGSDTAILLQVTV-ETTGTLLVGADIAAA-ATVAHALGVDSLGLNCAT 224
            AAI A +        +  I++  T+ + +G  L G    A   +V HA  + S+GLNCA 
Sbjct: 194  AAIFAVQQVFEDDNVELPIMISGTITDASGRTLSGQTTEAFWNSVRHAKPI-SVGLNCAL 252

Query: 225  GPQEMSEHVRWLKENWPGLISLQPNAGLPELLDGKTHYPLTPAELADWHGRFIREDGVNL 284
            G +++  ++  L       +S  PNAGLP        Y  TPAE+A     F     +N+
Sbjct: 253  GAKDLRPYLEELATKADTHVSAHPNAGLPNAFG---EYDETPAEMAAVVEEFAASGFLNI 309

Query: 285  IGGCCGTTPDHIAAVNAMLETLGQGRRPAPVKRSVHWVPSVAS---LYGAVPMR--QENA 339
            IGGCCGTTP HI A+             A  K     +P +A    L G  P    +++ 
Sbjct: 310  IGGCCGTTPGHIQAI-----------AEAVAKYKPREIPEIAKACRLSGLEPFTIDRQSL 358

Query: 340  FLSIGERCNANGSKKFRTFQDNEDWDAIVGMAREQVKEGSHTLDVCTAFVGRKEGADMTE 399
            F+++GER N  GS KF      E++   + +A +QV+ G+  +D+          A M  
Sbjct: 359  FVNVGERTNITGSAKFARLIREENYTEALEVALQQVEAGAQVIDINMDEGMLDSQAAMVR 418

Query: 400  VVSRLRGGVN---APLVIDSTETPVLTQALKLYGGKAIINSINFEDGEESAAQRLALARE 456
             ++ + G  +    P++IDS++  V+   LK   GK I+NSI+ ++G E       L + 
Sbjct: 419  FLNLIAGEPDISRVPIMIDSSKWEVIEAGLKCIQGKGIVNSISMKEGVEQFKHHARLCKR 478

Query: 457  FGAAVIALTIDEEGMAKDAEAKLRIAHRLYDFAVTQHGLPASDLMFDPLTFTICTGNTDD 516
            +GAAV+ +  DE G A  A  K  I  R YD  V + G P  D++FDP  F + TG  + 
Sbjct: 479  YGAAVVVMAFDEVGQADTAARKKEICQRSYDILVNEVGFPPEDIIFDPNIFAVATGIEEH 538

Query: 517  RRLGLETLDAIRRIRTELPECQIILGLSNISF---GLKPVARHVLNSVFLDKAVEAGMTG 573
                ++ ++A   IR  LP      G+SN+SF   G  PV R  ++SVFL  A++ G+T 
Sbjct: 539  NNYAVDFIEACAYIRDHLPHALSSGGVSNVSFSFRGNNPV-REAIHSVFLYHAIQNGLTM 597

Query: 574  AIVHISKILPLHKIPADEVKAAEDLIFDRRAPGYDPLHAFIALFEDRSETKVAVK---RA 630
             IV+  ++    +IPA   +  ED++ +R   G D L A    ++    TK       R+
Sbjct: 598  GIVNAGQLEIYDEIPAQLREKVEDVVLNRTPHGTDALLAIADDYKGGGATKEVENEEWRS 657

Query: 631  ETVEERLKQRIVDGDRLGLDADLTEAMGKY--PPLEIINSLLLDGMKVVGELFGAGKMQL 688
              VE+RL+  +V G    +  D TEA  +    P+E+I   L++GM VVG+LFGAGKM L
Sbjct: 658  LPVEKRLEHALVKGITAFIVED-TEACRQQCARPIEVIEGPLMNGMNVVGDLFGAGKMFL 716

Query: 689  PFVLQSAETMKAAVAFLEPHMEKIEG---QEKGIIVLATVKGDVHDIGKNLVDIILSNNG 745
            P V++SA  MK AVA L P +E  +G   + KG I++ATVKGDVHDIGKN+V ++L  NG
Sbjct: 717  PQVVKSARVMKQAVAHLIPFIEAEKGDKPEAKGKILMATVKGDVHDIGKNIVGVVLGCNG 776

Query: 746  YKVINIGIKQPIAAILASARENRADAIGMSGLLVKSTVIMKDNLEEMAREGWNTPVLLGG 805
            Y ++++G+  P   IL +ARE + D IG+SGL+  S   M     EM R+G+  P+++GG
Sbjct: 777  YDIVDLGVMVPAEKILQTAREQKCDIIGLSGLITPSLDEMVHVAREMQRQGFELPLMIGG 836

Query: 806  AALTRAFVEEDCVSAYAGSGRVAYARDAFDGL----DLMAKVAEGRF--DTHLS--AVQQ 857
            A  ++A         Y+    V Y  DA   +     L++K  +  F   T L    V++
Sbjct: 837  ATTSKAHTAVKIEPKYSNDA-VIYVTDASRAVGVATQLLSKELKPGFVEKTRLEYVDVRE 895

Query: 858  KRAGRPSRRPKAPPLWPANDPSSKIAPRTLDDQDTAIHKISERPVDAEEILLRRAELARD 917
            + A R +R                                +ER   A+ I  +       
Sbjct: 896  RTANRSAR--------------------------------TERLSYAQAIAAKPQYDWAG 923

Query: 918  HVVPTPPFWGAKVLESISLKSLVPYINEATLFQFQWGFRKGGRTREEWKDWAASEIRPIM 977
            +    P F G KVLE I L++L  YI + T F   W     G+      D    E    +
Sbjct: 924  YQPTAPSFTGVKVLEDIDLRTLAEYI-DWTPFFISWDL--AGKFPRILTDEVVGEAATAL 980

Query: 978  F----DMLKTCAQEEILKPRAVYGFWKAAS-QGDAIVLFAEDGTTEVGRFDLPRQTI--- 1029
            +    +ML     E+++  RAV+GFW A     D I ++ EDG        L +QTI   
Sbjct: 981  YKDAREMLDKLIDEKLISARAVFGFWPANQVDDDDIEVYGEDGQALATLHHLRQQTIKPD 1040

Query: 1030 -EGGICLADFVRDIDSGERDVIALQAVTVGARASDVCRDWFAANRYKDYLYLHGISVEVA 1088
             +    LADFV   DSG  D +     T G  A +V + +         + +  ++  +A
Sbjct: 1041 GKPNWSLADFVAPKDSGVTDYVGGFITTAGIGAEEVAKAYQDKGDDYSSIMVKALADRLA 1100

Query: 1089 EAMAEYVHKRIRAE-LGFAAEEARDIERMIKQEYRGSRYSFGYPACPNLGDQRQLLDLLG 1147
            EA AE++H+++R E  G+A +E  D E +IK++Y G R + GYPACP+  ++  L  LL 
Sbjct: 1101 EACAEWLHEQVRKEHWGYARDEHLDNEALIKEQYSGIRPAPGYPACPDHTEKETLFRLLD 1160

Query: 1148 AERI------ELDLSDEDELVPEQSTSALVLLHPQAKYFRI 1182
               I       + L++   + P  + S     HPQAKYF +
Sbjct: 1161 GTAIGETGPSGVYLTEHFAMFPAAAVSGWYFAHPQAKYFAV 1201