Pairwise Alignments

Query, 1030 a.a., RND efflux transporter from Pseudomonas putida KT2440

Subject, 1016 a.a., AcrB/AcrD/AcrF family protein from Vibrio cholerae E7946 ATCC 55056

 Score =  507 bits (1306), Expect = e-147
 Identities = 302/1018 (29%), Positives = 543/1018 (53%), Gaps = 15/1018 (1%)

Query: 7    NLSALAVRERSITLFLIVLIAFAGTLAFFKLGRAEDPPFTVKQMTIITAWPGATAQEMQD 66
            +++   + +R+    LI L    G +++ KLGR EDP F ++Q  I+T +PGATAQE+ D
Sbjct: 2    DIARYTLAKRTSVWVLIALTLIGGYISYLKLGRFEDPEFVIRQAVIVTPYPGATAQEVSD 61

Query: 67   LVAEPLEKRMQELRWYDRTETYTRPGLAFTMVSLQDKTPPSA--VQEEFYQARKKAGDQA 124
             V + +E  +Q L+     ++ +  G +   V ++ +   S+  +Q+ + + R+K  D  
Sbjct: 62   EVTDVIEGAVQALQELKEVKSVSMQGRSEVTVEIKLEFAKSSAQLQQVWDKLRRKVADAQ 121

Query: 125  KLMPAGVIGPMLNDEFSDVTFAVYALKAKGEPQRQLVRDAETLRQQLLHVPGVKKVNIIG 184
            + +P G    ++ND+FSDV    YA+  +G   +QL    +TLR++L+ VPGV K   + 
Sbjct: 122  RQLPPGAGASIVNDDFSDVYALFYAVTGEGFSDKQLQDYVDTLRRELVLVPGVAKAATLA 181

Query: 185  EQAERIFVSFSHDRLATLGITPQDIFSALDNQNALSPSGSVETQGPQVVVRVDGAFDQLA 244
            EQ E IF+  S +R+A  G++ + +   L  Q+ ++ +GSV+ Q  ++ V        LA
Sbjct: 182  EQQEAIFIEMSSERMAEFGLSVERVLQVLQKQSLVTVAGSVDAQQMRIPVIPKSNISSLA 241

Query: 245  KIRETPVV--AQGRPLKLSDVADVERGYEDPATFLVRNDGEPALLLGIVMREGWNGLDLG 302
             +    V   +    ++L D+A++ RGY +PA+ L+R +G+ A+  GI    G N +++G
Sbjct: 242  DLTNLQVAVGSNNAVVRLGDIANISRGYTEPASMLMRYNGQRAIGFGISNVTGGNVVEMG 301

Query: 303  KALEAETAKINEGMPLGMTLSKVTDQAVNITSSVDEFMIKFFVALLVVMLVCFLSMGWRV 362
             A++A  A++    PLGM L  ++ Q+ ++ +SV  F+     A+ +V +V  L MG R 
Sbjct: 302  DAVKARLAELESQRPLGMDLHVISMQSDSVRASVANFIDNLIAAVAIVFVVLLLFMGVRS 361

Query: 363  GVVVAAAVPLTLAIVFVVMAATGKNFDRITLGSLILALGLLVDDAIIAIEMMVVKMEE-- 420
            GV++   + LT+A    VM        RI+LG+LI+ALG+LVD+AI+  + ++V+ ++  
Sbjct: 362  GVIIGFVLLLTVAGTLCVMLIDDIAMQRISLGALIIALGMLVDNAIVVTDGVLVRFQQEP 421

Query: 421  GYDRIKASAYAWSHTAAPMLSGTLVTAIGFMPNGFAQSTAGEYTSNMFWIVGIALIASWV 480
              D+ +  +   + T  P+L GT+V    F   G + S  GEY  ++FW++  ++  SWV
Sbjct: 422  NADKQQVVSEVVNATKWPLLGGTVVGIFAFSAIGLSPSDMGEYAGSLFWVILYSMFLSWV 481

Query: 481  VAVAFTPYLGVKLLPRIKTIEGGHAAIYNTRHYNRFRALLGWVIAHKWLVAGTVVSTFVA 540
             AV  TP L    L     ++        ++    ++A+L WV++H+ +    ++ T VA
Sbjct: 482  FAVTVTPMLCHDFL----RVKAPTKEAKPSKLVTGYKAVLQWVLSHRVVSCAMLLGTLVA 537

Query: 541  AVLGMGLVKKQFFPTSDRPEVLVELQMPYGTSIEQTNATAIKVESWLRQQEEAKIVTTYI 600
            AV G   +   F P S RP+ +V++ +P G+ I +T      +E  + Q++    +T++I
Sbjct: 538  AVWGAQFIPPGFMPESQRPQFVVDVYLPQGSDIRRTEQVVASIEKDVTQKDGITNITSFI 597

Query: 601  GQGPPRFFLAMAPELPDPSFAKIVVLTENQGAREALKHRLREAASEGLAPGAQVRVTQLV 660
            G G  RF L  +PE  +PS+ ++++  ++      L   L+    +   P A ++V + +
Sbjct: 598  GGGGLRFMLTYSPEARNPSYGQLLIDIDDYTKIAPLVGELQNEL-DAKYPDASIKVWKFM 656

Query: 661  FGPYSPYPVAYRVMGPDASQLRQIAARVQSVLQASPMMKTVNTDWGPLVPTLHFSLNQDR 720
             G      +     GPD+  LRQ+A + ++++   P +  V  DW   VP L    +   
Sbjct: 657  LGRGGGKKIEAGFKGPDSHVLRQLAEQAKAIMHNDPNLIAVQDDWRQQVPVLQPVYSAQE 716

Query: 721  LQSVGLTSASVSQQLQFLLTGVPITSVREDIRSVQVVGRAAGQIRLDPAQIENFTLVGSN 780
             Q +GLT+  +S  +   L G  +   RE    + ++ RA    R     IEN  +  + 
Sbjct: 717  AQRLGLTTQEISAAIAQTLNGRNVGVYREGNDLIPLMVRAPENERHHERAIENSEVFSAQ 776

Query: 781  -GQRVPVSQIGD-VSIRMEDPILRRRDRTPTMTVRGDIAEGLQPPDVSTAIWKDLQPIVT 838
             G+ +PVSQ+ D V    +D +LRR +R PT+ V+ D A G+   D    + + ++ I  
Sbjct: 777  AGRYIPVSQLVDSVDTVYQDALLRRINRMPTILVQADPAPGVMTADAFNNVREKIEQI-- 834

Query: 839  QLPAGYKIEMAGSIEESAKASQAIVPLLPIMIALTLLIIILQVRSISAMVMVFLTSPLGL 898
            +LPAGY++   G  + S  A++ +    P   A  +L ++    ++   +++++T+P  +
Sbjct: 835  ELPAGYELIWYGEYKASKDANEGLALSAPYGFAAMILAVVFMFNALRQPLVIWMTAPFAV 894

Query: 899  IGVVPVLLLFGQPFGINALVGLIALSGILMRNTLILIGQIDHNQLEGLAPFDAVVEATVQ 958
            +GV   L+ F  PF   A++G ++L G++++N ++L+ Q D     G   + A+++A V 
Sbjct: 895  VGVTIGLIAFQTPFEFMAILGFLSLIGMMVKNAIVLVDQADAEIRAGKEAYFAIIDAAVS 954

Query: 959  RARPVLLTALAAILAFIPLTHSVFWGTLAYTLIGGTFVGTIMTLVFLPAMYSIWFKIR 1016
            RARPVLL A   IL   PL    F+ ++A T++ G    TI+TLV +P  Y++ F+++
Sbjct: 955  RARPVLLGAFTTILGVAPLLVDPFFKSMAVTIMFGLLFATILTLVVIPLFYAVLFRVK 1012



 Score = 52.8 bits (125), Expect = 1e-10
 Identities = 108/520 (20%), Positives = 203/520 (39%), Gaps = 35/520 (6%)

Query: 524  IAHKWLVAGTVVSTFVAAVLGMGLVKKQFFPTSDRPEVLVELQM-----PYGTSIEQTNA 578
            IA   L   T V   +A  L  G +        + PE ++   +     P  T+ E ++ 
Sbjct: 3    IARYTLAKRTSVWVLIALTLIGGYISYLKLGRFEDPEFVIRQAVIVTPYPGATAQEVSDE 62

Query: 579  TAIKVESWLRQQEEAKIVTTYIGQGPPRFFLAMAPELPDPSFAKIVVLTENQGAREALKH 638
                +E  ++  +E K V +   QG     + +  E    S        + Q   + L+ 
Sbjct: 63   VTDVIEGAVQALQELKEVKSVSMQGRSEVTVEIKLEFAKSS-------AQLQQVWDKLRR 115

Query: 639  RLREAASEGLAPGAQVRVTQLVFGPYSPYPVAYRVMGPDAS--QLRQIAARVQSVLQASP 696
            ++ +A  + L PGA   +    F     Y + Y V G   S  QL+     ++  L   P
Sbjct: 116  KVADAQRQ-LPPGAGASIVNDDFSDV--YALFYAVTGEGFSDKQLQDYVDTLRRELVLVP 172

Query: 697  MMKTVNTDWGPLVPTLHFSLNQDRLQSVGLTSASVSQQLQFLLTGVPITSVREDIRSVQV 756
             +    T        +   ++ +R+   GL+   V Q LQ         SV      + V
Sbjct: 173  GVAKAAT-LAEQQEAIFIEMSSERMAEFGLSVERVLQVLQKQSLVTVAGSVDAQQMRIPV 231

Query: 757  VGRAAGQIRLDPAQIENFTLVGSNGQRVPVSQIGDVSIRMEDP--ILRRRDRTPTMTVRG 814
            + ++      D   ++    VGSN   V +  I ++S    +P  +L R +    +    
Sbjct: 232  IPKSNISSLADLTNLQ--VAVGSNNAVVRLGDIANISRGYTEPASMLMRYNGQRAIGFGI 289

Query: 815  DIAEGLQPPDVSTAIWKDLQPIVTQLPAGYKIEMAGSIEESAKASQAIVP---LLPIMIA 871
                G    ++  A+   L  + +Q P G  + +     +S +AS A      +  + I 
Sbjct: 290  SNVTGGNVVEMGDAVKARLAELESQRPLGMDLHVISMQSDSVRASVANFIDNLIAAVAIV 349

Query: 872  LTLLIIILQVRSISAMVMVFLTSPLGLIGVVPVLLLFGQPFGINALVGLIALSGILMRNT 931
              +L++ + VRS   +  V L +  G + V+ +  +  Q   + AL+  IAL G+L+ N 
Sbjct: 350  FVVLLLFMGVRSGVIIGFVLLLTVAGTLCVMLIDDIAMQRISLGALI--IAL-GMLVDNA 406

Query: 932  LILI-GQIDHNQLEGLAPFDAVVEATVQRAR-PVLLTALAAILAFI-----PLTHSVFWG 984
            +++  G +   Q E  A    VV   V   + P+L   +  I AF      P     + G
Sbjct: 407  IVVTDGVLVRFQQEPNADKQQVVSEVVNATKWPLLGGTVVGIFAFSAIGLSPSDMGEYAG 466

Query: 985  TLAYTLIGGTFVGTIMTLVFLPAMYSIWFKIRPNSRIAKP 1024
            +L + ++   F+  +  +   P +   + +++  ++ AKP
Sbjct: 467  SLFWVILYSMFLSWVFAVTVTPMLCHDFLRVKAPTKEAKP 506