Pairwise Alignments

Query, 1237 a.a., methionine synthase from Pontibacter actiniarum KMM 6156, DSM 19842

Subject, 1192 a.a., 5-methyltetrahydrofolate--homocystein methyltransferase MetH (methionine synthase, vitamin-B12 dependent isozyme) (ms) from Mycobacterium tuberculosis H37Rv

 Score =  548 bits (1413), Expect = e-160
 Identities = 390/1221 (31%), Positives = 618/1221 (50%), Gaps = 79/1221 (6%)

Query: 10   LLQERVLVLDGAMGTMIQRYQLQEADFRGERFQDHASDLKGNNDLLSITRPDVIKAIHAE 69
            +L +RV+V DGAMGT +Q   L   DFRG         L+G N++L+ TRPDV++ IH  
Sbjct: 16   VLSQRVMVGDGAMGTQLQAADLTLDDFRG---------LEGCNEILNETRPDVLETIHRN 66

Query: 70   YLEAGADIIETNTFSGTSIAMADYHLEHIVYELNYESARLAREAADEIEAKVPGKPRFVA 129
            Y EAGAD +ETNTF      + DY +   + +L+ +   +AR  ADE+ +  P + R+V 
Sbjct: 67   YFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGS--PDRKRYVL 124

Query: 130  GAIGPTNRTASLSPDVNNPGYRAITFDQLVEAYCEQVRGLVDGGSNLLLVETVFDTLNCK 189
            G++GP  +     P + +  Y  I      +AY E   G++DGG++ +LVET  D L  K
Sbjct: 125  GSMGPGTKL----PTLGHTEYAVIR-----DAYTEAALGMLDGGADAILVETCQDLLQLK 175

Query: 190  AALFAIDQYVQDGGKALPIMVSGTITDASGRTLSGQTVEAFWNSISHAPILSIGFNCALG 249
            AA+    + +   G+ +P+    T+ + +G  L G  + A   ++    +  IG NCA G
Sbjct: 176  AAVLGSRRAMTRAGRHIPVFAHVTV-ETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATG 234

Query: 250  ARQLKTHIKELSRISDCYISAYPNAGLP--NAFGG-YDETAQQMGEIVEEYLKEGLVNIL 306
              ++  H++ LSR +   +S  PNAGLP   A G  Y     ++ E +  ++ E  ++++
Sbjct: 235  PAEMSEHLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLV 294

Query: 307  GGCCGTTPVHTKVISDLVQKYKPHVPTPVAPLPRYSGLEPLTIYPESLFVNV-GERTNVT 365
            GGCCGTTP H + ++  V   K      V+  P  S L     + +   V V GERTN  
Sbjct: 295  GGCCGTTPAHIREVAAAVANIK-RPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNAN 353

Query: 366  GSKKFARLIVEEKFEEALSVAQQQVEGGAQIIDVNMDEGMLDSEQAMTNFLNLIASEPDI 425
            GSK F   ++ E +++ L +A+ Q   GA ++D+ +D    D    M    + +A+    
Sbjct: 354  GSKGFREAMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATS--- 410

Query: 426  SKLPIMIDSSKWSVIEAGLKCVQGKSIVNSISLKEG---EENFKKVARKVRQYGAAVVVM 482
            S LPIM+DS++ +V++AGL+ + G+  +NS++ ++G   E  F K    V ++GAAVV +
Sbjct: 411  STLPIMLDSTETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVAL 470

Query: 483  AFDEQGQADTFERRIEICEKSYRILVDEVGFPPQDIIFDPNILAIATGIEEHNNYAVDYI 542
              DE+GQA T ++++EI E+    +    G     I+ D     IATG EE     ++ I
Sbjct: 471  TIDEEGQARTAQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETI 530

Query: 543  ETIKWIKANLPHALVSGGVSNLSFSFRGNDVVREAMHTVFLYYAVQAGMDMGIVNAGMMG 602
            E I+ +K   P    + G+SN+SF    N   R+ +++VFL+   +AG+D  IV+A  + 
Sbjct: 531  EAIRELKKRHPDVQTTLGLSNISFGL--NPAARQVLNSVFLHECQEAGLDSAIVHASKIL 588

Query: 603  VYSEIPTELRDLIEDVIFNRHPDATEKLVTYAETIKGKGKGAAQADNSWREA--PVEERL 660
              + IP E R++  D++++R  +  + L       +G    +++ D     A  P+ ERL
Sbjct: 589  PMNRIPEEQRNVALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERL 648

Query: 661  KHALVKGIVEFIEEDTEEARQKATKTLEVIEGPLMAGMTVVGDLFGAGKMFLPQVVKSAR 720
               +V G    ++ D +EA  +    L++I   L+AGM  VG+LFG+G+M LP V++SA 
Sbjct: 649  AQRIVDGERNGLDADLDEAMTQKPP-LQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAE 707

Query: 721  VMKKSVAYLLPFMEAEKLASDTSKSTAGTILMATVKGDVHDIGKNIVGVVLACNNYEVID 780
            VMK +VAYL P ME      D+ K   G I++ATVKGDVHDIGKN+V ++L+ N YEV++
Sbjct: 708  VMKAAVAYLEPHMERSD--DDSGK---GRIVLATVKGDVHDIGKNLVDIILSNNGYEVVN 762

Query: 781  LGVMVSLDKILAEAEAQQVDIIGLSGLITPSLDEMVYVAQEMERRGM--KIPLLIGGATT 838
            +G+   +  IL  AE +  D++G+SGL+  S   M    +EM  RG+  K P+L+GGA  
Sbjct: 763  IGIKQPIATILEVAEDKSADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAAL 822

Query: 839  SRVHTAVKIAPQYSGPVVHVHDASRSVTVVSSLLGSDR-----ENYIAEIKAEYEKLRED 893
            +R +    +A  Y G V +  DA   + ++ +++ + R     EN    IKA  EK  E 
Sbjct: 823  TRSYVENDLAEIYQGEVHYARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAR-EKEAER 881

Query: 894  HLNRTKDRAFASIGEARANKYKV----DWAA-TRPTKPSFLGNKVYTNYPLSEIVPFIDW 948
                 + +  A+  +A     +V    D AA      P F G+++     +++    +D 
Sbjct: 882  KARHQRSKRIAAQRKAAEEPVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDE 941

Query: 949  TP-FFHTWELKRQY----PKILDDAELGTEARKLFADAQQMLQEIVDNQLLEARAVVGFY 1003
               F   W L+ Q     P   D  E  TE R         L    D  L  A  V G++
Sbjct: 942  RALFLGQWGLRGQRGGEGPSYEDLVE--TEGRPRLRYWLDRLS--TDGILAHAAVVYGYF 997

Query: 1004 PANVEADDTIEVYADDSRENELTEFHTLRQQGKKGQGVPNMAFSDFIAPK----ETGVQD 1059
            PA  E +D + +            FH  RQQ  +      +  +DFI  +    E G  D
Sbjct: 998  PAVSEGNDIVVLTEPKPDAPVRYRFHFPRQQRGR-----FLCIADFIRSRELAAERGEVD 1052

Query: 1060 YIGGFVVSAGFGIEKMLEQYEAEHDDYRSIMAKALADRLAEAFAELMHLKVRREL----- 1114
             +   +V+ G  I     +  A +     +    +  +L EA AE  H ++R EL     
Sbjct: 1053 VLPFQLVTMGQPIADFANELFASNAYRDYLEVHGIGVQLTEALAEYWHRRIREELKFSGD 1112

Query: 1115 WGYSPEEQLSNEDLIKEQYKGIRPAPGYPGCPDHTEKITLFNLLNAEEQTGIILTENLAM 1174
               + E+  + ED  K  Y+G R A GY  CPD  ++  +  LL   E+ G+ L+E L +
Sbjct: 1113 RAMAAEDPEAKEDYFKLGYRGARFAFGYGACPDLEDRAKMMALLE-PERIGVTLSEELQL 1171

Query: 1175 YPASSVSGLYFSHPESKYFGL 1195
            +P  S       HPE+KYF +
Sbjct: 1172 HPEQSTDAFVLHHPEAKYFNV 1192