Pairwise Alignments
Query, 405 a.a., Possible multifunctional enzyme siroheme synthase CysG: uroporphyrin-III C-methyltransferase (urogen III methylase) (SUMT) (uroporphyrinogen III methylase) (UROM) + precorrin-2 oxidase + ferrochelatase from Mycobacterium tuberculosis H37Rv
Subject, 457 a.a., fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase from Escherichia coli BL21
Score = 202 bits (513), Expect = 2e-56 Identities = 141/444 (31%), Positives = 214/444 (48%), Gaps = 63/444 (14%) Query: 11 RLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAM---DQITLSVRDYRDG 67 +L + ++VGGG VA+R+ LL+ +GA + V A + P A +TL + + Sbjct: 9 QLRDRDCLIVGGGDVAERKARLLLDAGARLTVNALAFIPQFTAWADAGMLTLVEGPFDES 68 Query: 68 DLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAGLSVGVLA 127 LD W AIAATDD +N V AE RRIFC D + + P+ + L V V + Sbjct: 69 LLDTCWLAIAATDDDALNQRVSEAAEARRIFCNVVDAPKAASFIMPSIIDRSPLMVAVSS 128 Query: 128 GG-------------------------------------------EHRR---SAAIRSAI 141 GG E RR + + Sbjct: 129 GGTSPVLARLLREKLESLLPLHLGQVAKYAGQLRGRVKQQFATMGERRRFWEKLFVNDRL 188 Query: 142 REAL---QQGVITAQSSDVLS------GGVALVGGGPGDPELITVRGRRLLAQADVVVAD 192 ++L Q IT + +++ G V LVG GPGD L+T++G + + QADVVV D Sbjct: 189 AQSLANNDQKAITETTEQLINEPLDHRGEVVLVGAGPGDAGLLTLKGLQQIQQADVVVYD 248 Query: 193 RLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNFVVRLKGGDPFVFA 252 RL +++ + + + K + Q+ IN +L+ A+ G VVRLKGGDPF+F Sbjct: 249 RLVSDDIMNLVRRDADRVFVGKRAGYHCVPQEEINQILLREAQKGKRVVRLKGGDPFIFG 308 Query: 253 RGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVVVSGHLAPGHPESL 312 RG EE+ +AGIP +VVPG+T+A A +G+P+THR +++GHL G Sbjct: 309 RGGEELETLCNAGIPFSVVPGITAASGCSAYSGIPLTHRDYAQSVRLITGHLKTG---GE 365 Query: 313 VNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGTTAAQQTLRATLAD 372 ++W+ LAA T+V M + + L++ G + PV +V++GT Q+ + TL Sbjct: 366 LDWENLAAEKQTLVFYMGLNQAATIQQKLIEHGMPGEMPVAIVENGTAVTQRVIDGTLTQ 425 Query: 373 TPEKVRAAGIRPPAIIVIGAVVGL 396 E A + P++I+IG VVGL Sbjct: 426 LGE--LAQQMNSPSLIIIGRVVGL 447