Pairwise Alignments

Query, 1231 a.a., Multifunctional alpha-ketoglutarate metabolic enzyme from Mycobacterium tuberculosis H37Rv

Subject, 933 a.a., 2-oxoglutarate dehydrogenase E1 component (EC 1.2.4.2) from Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

 Score =  684 bits (1764), Expect = 0.0
 Identities = 385/895 (43%), Positives = 539/895 (60%), Gaps = 37/895 (4%)

Query: 343  EVFRELSIPYLPVRWSTDNPDSIVDKNARVMNLIAAYRNRGHLMADTDPLRLDKARFRSH 402
            E FR  ++       +  +PD+ V K  +V+ LI AYR RGH  A+ DPL L K    + 
Sbjct: 64   EYFRRQALAGSRHSSTISDPDTNV-KQVKVLQLINAYRFRGHQHANLDPLGLWKQERVA- 121

Query: 403  PDLEVLTHGLTLWDLDRVFKVDGFA-GAQYKKLRDVLGLLRDAYCRHIGVEYAHILDPEQ 461
             DL+   H LT  D    F V  FA G +  KL ++L  L+  YC  IG EY HI   E+
Sbjct: 122  -DLDPSFHDLTEADFQETFNVGSFASGKETMKLGELLDALKQTYCGPIGAEYMHITSTEE 180

Query: 462  KEWLEQRVETKHVKPTVAQQKYILSKLNAAEAFETFLQTKYVGQKRFSLEGAESVIPMMD 521
            K W++QR+E+     +  ++K  L++L AAE  E +L  K+ G KRFSLEG +++IPM+ 
Sbjct: 181  KRWIQQRIESGRAAFSADEKKRFLNELTAAEGLERYLGAKFPGAKRFSLEGGDALIPMLK 240

Query: 522  AAIDQCAEHGLDEVVIGMPHRGRLNVLANIVGKPYSQIFTEFEGNLNPSQAHGSGDVKYH 581
              +      G  EVV+GM HRGRLNVL N++GK    +F EF G     +  G+GDVKYH
Sbjct: 241  EMVRHAGNSGTREVVLGMAHRGRLNVLINVLGKKPQDLFDEFAGK--HKEHLGTGDVKYH 298

Query: 582  LGATGLYLQMFGDNDIQVSLTANPSHLEAVDPVLEGLVRAKQDLLDHGSIDSDGQRAFSV 641
            +G +       G   + ++L  NPSHLE V PV+ G VRA+ D LD  S +        V
Sbjct: 299  MGFSSDIETEGGL--VHLALAFNPSHLEIVSPVVMGSVRARLDRLDEPSSNK-------V 349

Query: 642  VPLMLHGDAAFAGQGVVAETLNLANLPGYRVGGTIHIIVNNQIGFTTA-PEYSRSSEYCT 700
            +P+ +HGDAA  GQGVV ETLN++   GY VGGT+ I++NNQ+GFTT+ P  +RS+ YCT
Sbjct: 350  LPITIHGDAAVTGQGVVQETLNMSKARGYEVGGTVRIVINNQVGFTTSNPLDARSTPYCT 409

Query: 701  DVAKMIGAPIFHVNGDDPEACVWVARLAVDFRQRFKKDVVIDMLCYRRRGHNEGDDPSMT 760
            D+ KM+ APIFHVN DDPEA  +V RLA+DFR  FK+DV ID++CYRR GHNE D+PS T
Sbjct: 410  DIGKMVQAPIFHVNADDPEAVAFVTRLALDFRNTFKRDVFIDLVCYRRHGHNEADEPSAT 469

Query: 761  NPYVYDVVDTKRGARKSYTEALIGRGDISMKEAEDALRDYQGQL---ERVFNEVRELEKH 817
             P +Y  +      RK Y + L      ++++A + +  Y+  L   E V  E R +  H
Sbjct: 470  QPLMYQKIKKHPTPRKIYADKLEADKVATLEDATEMVNLYRDALDAGECVVKEWRPMNMH 529

Query: 818  GV--QPSESVESDQMIPAGLATAVDKSLLARIGDAFLALPNGFTAHPRVQPVLEKRREMA 875
                 P  + E D+  P      V+   L  +      +P       RV  +   R+ MA
Sbjct: 530  SFTWSPYLNHEWDEAYP----NKVEMKRLQELAKRISTVPEAIEMQSRVAKIYGDRQAMA 585

Query: 876  YEGKI-DWAFGELLALGSLVAEGKLVRLSGQDSRRGTFSQRHSVLIDRHTGEEFTPLQLL 934
               K+ DW   E LA  +LV EG  VRLSG+DS RGTF  RH+V+ ++  G  +TPLQ +
Sbjct: 586  AGEKLFDWGGAENLAYATLVDEGIPVRLSGEDSGRGTFFHRHAVIHNQTNGSTYTPLQHI 645

Query: 935  ATNSDGSPTGGKFLVYDSPLSEYAAVGFEYGYTVGNPDAVVLWEAQFGDFVNGAQSIIDE 994
             +        G+F V+DS LSE A + FEYGY    P  + +WEAQFGDF NGAQ +ID+
Sbjct: 646  HSGQ------GQFKVWDSVLSEEAVLAFEYGYATAEPRTLTIWEAQFGDFANGAQVVIDQ 699

Query: 995  FISSGEAKWGQLSNVVLLLPHGHEGQGPDHTSARIERFLQLWAEGSMTIAMPSTPSNYFH 1054
            FISSGE KWG++  +V+LLPHG+EGQGP+H+SAR+ER+LQL AE +M + +PSTP+  +H
Sbjct: 700  FISSGEQKWGRMCGLVMLLPHGYEGQGPEHSSARLERYLQLCAEQNMQVCVPSTPAQVYH 759

Query: 1055 LLRRHALDGIQRPLIVFTPKSMLRHKAAVSEIKDFTEIKFRSVLEEPTYEDGIGDRNKVS 1114
            +LRR AL G++RPL+V +PKS+LRH  AVS + +     F+  + E    D + D   V 
Sbjct: 760  MLRRQALRGMRRPLVVMSPKSLLRHPLAVSTLDELANGSFQPAIGE---IDEL-DPKAVK 815

Query: 1115 RILLTSGKLYYELAARKAKDNRNDLAIVRLEQLAPLPRRRLRETLDRYENVKEFFWVQEE 1174
            R+++ SGK+YY+L  ++ K+++ D+AIVR+EQL P P + ++E L  Y +V +F W QEE
Sbjct: 816  RVVMCSGKVYYDLLEQRRKNDQKDVAIVRIEQLYPFPHKAVQEALQPYAHVHDFVWCQEE 875

Query: 1175 PANQGAWPRFGLELPELLPDKLAGIKRISRRAMSAPSSGSSKVHAVEQQEILDEA 1229
            P NQGAW        E+ P   A ++   R A ++P+ G   VH  +QQ+++++A
Sbjct: 876  PLNQGAWYCSQHHFREVTPFG-AALRYAGRPASASPAVGYMSVHQKQQQDLVNDA 929



 Score = 30.8 bits (68), Expect = 6e-04
 Identities = 11/25 (44%), Positives = 16/25 (64%)

Query: 9  GQNEWLVEEMYRKFRDDPSSVDPSW 33
          G N+  +E++Y  F  DP SVD +W
Sbjct: 17 GSNQSWIEQLYEDFLTDPDSVDANW 41