Pairwise Alignments

Query, 1231 a.a., Multifunctional alpha-ketoglutarate metabolic enzyme from Mycobacterium tuberculosis H37Rv

Subject, 1003 a.a., 2-oxoglutarate dehydrogenase E1 component from Brevundimonas sp. GW460-12-10-14-LB2

 Score =  708 bits (1828), Expect = 0.0
 Identities = 418/912 (45%), Positives = 556/912 (60%), Gaps = 60/912 (6%)

Query: 358  STDNPDSIVDKNARVMNLIAAYRNRGHLMADTDPLRLDKARFRSHPDLEVLTHGLTLWDL 417
            S D   +    + R + LI +YR RGHL A  DPL +++     +P+L    +G T  DL
Sbjct: 112  SADAIRAAAHDSIRALMLIRSYRVRGHLQAKLDPLGIEQPV--ENPELTPEFYGFTGADL 169

Query: 418  DRVFKVDGFAGAQYKKLRDVLGLLRDAYCRHIGVEYAHILDPEQKEWLEQRVETKHVKPT 477
            DR   +DG  G Q   +R+VL +L+  YC +IG+++ HI +PE+K WL+QR E       
Sbjct: 170  DRPIFLDGVLGLQTGTIREVLEILKRTYCGNIGIQFMHIAEPEEKSWLQQRFEGADKFEQ 229

Query: 478  VAQQKY----ILSKLNAAEAFETFLQTKYVGQKRFSLEGAESVIPMMDAAIDQCAEHGLD 533
             A  K     ILSKL  AE FE FL  ++ G KRF L+G E+++P ++  I +    G+D
Sbjct: 230  NAFSKEGKLAILSKLVEAEGFERFLHKRFPGTKRFGLDGGEAMVPALEQVIKRGGSLGVD 289

Query: 534  EVVIGMPHRGRLNVLANIVGKPYSQIFTEFEG-NLNPSQAHGSGDVKYHLGATGLYLQMF 592
            EVV+GM HRGRLNVLA ++GKPY  IF EF+G +  PS   GSGDVKYH+GA+    + F
Sbjct: 290  EVVLGMAHRGRLNVLAAVMGKPYKVIFHEFQGGSAVPSDIEGSGDVKYHMGASSN--REF 347

Query: 593  GDNDIQVSLTANPSHLEAVDPVLEGLVRAKQ--DLLDHGSIDSDGQRAFS---VVPLMLH 647
              N + +SLTANPSHLE V+PV+ G  RAKQ  D+ +      +GQ A     VVPL++H
Sbjct: 348  DGNHVHLSLTANPSHLEIVNPVVLGKARAKQAFDIREANEGVPEGQWALDRSKVVPLLIH 407

Query: 648  GDAAFAGQGVVAETLNLANLPGYRVGGTIHIIVNNQIGFTTAPEYSRSSEYCTDVAKMIG 707
            GDAAFAGQGVVAE   L  L GYR GGT+H ++NNQIGFTT+P  SRSS Y +DVA M+ 
Sbjct: 408  GDAAFAGQGVVAECFALMGLKGYRTGGTLHFVINNQIGFTTSPRNSRSSPYPSDVALMVQ 467

Query: 708  APIFHVNGDDPEACVWVARLAVDFRQRFKKDVVIDMLCYRRRGHNEGDDPSMTNPYVYDV 767
            APIFHVNGDDPEA V+ +++A ++RQ+F KDVV+DM CYRR GHNEGDDP+ T P +Y  
Sbjct: 468  APIFHVNGDDPEAVVFASKVATEYRQKFHKDVVVDMFCYRRFGHNEGDDPTFTQPLMYSK 527

Query: 768  VDTKRGARKSYTEALIGRGDISMKEAEDALRDYQGQLERVF--NEVRELEK--------H 817
            +  +   R+ Y++ L+  G IS  E +  +  ++  L+  F   +    EK         
Sbjct: 528  IRAQPSTRELYSQRLVAEGVISQAEVDAEVERFEKFLDEQFEAGKTWSAEKADWLDGQWQ 587

Query: 818  GVQ-PSESVESDQMIPAGLATAVDKSLLARIGDAFLALPNGFTAHPRVQPVLEKRREMAY 876
            G Q P + +  D        TAV  + L  +G     +PN    H  ++ V++ RRE   
Sbjct: 588  GFQSPKDELRGD--------TAVPLAKLTDLGHRLTTIPNSVDMHKTLKRVIDGRREAIT 639

Query: 877  EGK-IDWAFGELLALGSLVAEGKLVRLSGQDSRRGTFSQRHSVLIDRHTGEEFTPLQLLA 935
             G+ +DWA  E LA  SLV EG  +RLSGQDS RGTFSQRHS +ID+ T E + PL  L 
Sbjct: 640  SGQGLDWATAESLAFASLVDEGFPIRLSGQDSVRGTFSQRHSGIIDQTTEERYIPLNNLR 699

Query: 936  TNSDGSPTGGKFLVYDSPLSEYAAVGFEYGYTVGNPDAVVLWEAQFGDFVNGAQSIIDEF 995
                       F V DS LSE A +GFEYGY++ +P+ +V+WEAQFGDFVNGAQ +ID+F
Sbjct: 700  EGQ------ANFEVIDSALSEEAVLGFEYGYSLADPNTLVMWEAQFGDFVNGAQVVIDQF 753

Query: 996  ISSGEAKWGQLSNVVLLLPHGHEGQGPDHTSARIERFLQLWAEGSMTIAMPSTPSNYFHL 1055
            ISSGE KW ++S + +LLPHG+EGQGP+H+SAR+ERFLQ  AE +M +A  +TP+NYFH+
Sbjct: 754  ISSGERKWLRMSGLTMLLPHGYEGQGPEHSSARLERFLQQCAEDNMQVANCTTPANYFHI 813

Query: 1056 LRRHALDGIQRPLIVFTPKSMLRHKAAVSEIKDFTE-IKFRSVLEE--PTYEDGIGDRNK 1112
            LRR      ++PLI+ TPKS+LRHK AVS + D  E   F  VL +   T  +  G   K
Sbjct: 814  LRRQMHRPFRKPLILMTPKSLLRHKKAVSSMADLAEGSAFHRVLHDDAQTRPEIAGITIK 873

Query: 1113 ----VSRILLTSGKLYYEL---AARKAKDNR--NDLAIVRLEQLAPLPRRRLRETLDRYE 1163
                + R++L SGK+YY+L     +KAKD +  +D+ I+RLEQ  P P + LR+ L R+ 
Sbjct: 874  ADKDIRRVILCSGKVYYDLLDAREKKAKDGQAVDDVYILRLEQFYPWPIQSLRKELARFP 933

Query: 1164 NVKEFFWVQEEPANQGAWPRFGLELPELLPDKLAGIKRISRRAMSAPSSGSSKV-----H 1218
            N  E  W QEEP N G W  F     EL  DKL  +K    R +  P S S+       H
Sbjct: 934  NA-ELVWCQEEPKNMGGW-TFVDPWLELTLDKL-DVKAKRARYVGRPGSASTAAGLMSRH 990

Query: 1219 AVEQQEILDEAF 1230
              E +    EAF
Sbjct: 991  LKELEAFTTEAF 1002



 Score = 35.4 bits (80), Expect = 2e-05
 Identities = 30/107 (28%), Positives = 39/107 (36%), Gaps = 20/107 (18%)

Query: 2   ANISSPFGQNEWLVEEMYRKFRDDPSSVDPSWHEF---------LVDYS----------- 41
           A  S  +G N   VEE+  K+  DP SV   W  F         LV  S           
Sbjct: 13  AETSFLYGSNAAYVEELQEKWAKDPGSVSAEWKTFFDQLRDNAALVTASAGAGSWGRGVA 72

Query: 42  PEPTSQPAAEPTRVTSPLVAERAAAAAPQAPPKPADTAAAGNGVVAA 88
            EPT +      R  +P    +   AAP A P  A    + + + AA
Sbjct: 73  TEPTEETGVFDGRWPAPKPDPKKPGAAPAAAPTAASADVSADAIRAA 119