Pairwise Alignments

Query, 1231 a.a., Multifunctional alpha-ketoglutarate metabolic enzyme from Mycobacterium tuberculosis H37Rv

Subject, 998 a.a., oxoglutarate dehydrogenase E1 component from Agrobacterium fabrum C58

 Score =  724 bits (1870), Expect = 0.0
 Identities = 399/889 (44%), Positives = 554/889 (62%), Gaps = 41/889 (4%)

Query: 369  NARVMNLIAAYRNRGHLMADTDPLRLDKARFRSHPDLEVLTHGLTLWDLDRVFKVDGFAG 428
            + R + +I AYR RGHL A  DPL +  A    + +L   ++G    D DR   +D   G
Sbjct: 124  SVRAIMMIRAYRMRGHLHAKLDPLGIASA-VEDYNELSPKSYGFEESDYDRKIFIDNVLG 182

Query: 429  AQYKKLRDVLGLLRDAYCRHIGVEYAHILDPEQKEWLEQRVE--TKHVKPTVAQQKYILS 486
             +Y  +R+++ +L   YC  +GVE+ H+ +PE+K W+++R+E   K V  T   +K ILS
Sbjct: 183  LEYATVREMVEILERTYCSTLGVEFMHMSNPEEKGWIQERIEGPDKGVDFTPEGKKAILS 242

Query: 487  KLNAAEAFETFLQTKYVGQKRFSLEGAESVIPMMDAAIDQCAEHGLDEVVIGMPHRGRLN 546
            KL  AE +E FL  ++ G KRF L+G ES+IP ++  I +  + GL+EVV+GM HRGRLN
Sbjct: 243  KLVEAEGYEQFLDVRFKGTKRFGLDGGESLIPALEQIIKRGGQDGLEEVVLGMAHRGRLN 302

Query: 547  VLANIVGKPYSQIFTEFEG-NLNPSQAHGSGDVKYHLGATGLYLQMFGDNDIQVSLTANP 605
            VL N++GKP+  +F EF+G +  P    GSGDVKYHLGA+    + F  N + +SLTANP
Sbjct: 303  VLTNVMGKPHRAVFHEFKGGSFKPDDVEGSGDVKYHLGASSD--REFDGNKVHLSLTANP 360

Query: 606  SHLEAVDPVLEGLVRAKQDLLDH---GSIDSDGQRAFSVVPLMLHGDAAFAGQGVVAETL 662
            SHLE V+PV+ G  RAKQD L     G I    +RA  V+PL+LHGDAAFAGQGVVAE L
Sbjct: 361  SHLEIVNPVVMGKARAKQDQLAKTWDGDIIPLSERA-KVLPLLLHGDAAFAGQGVVAEIL 419

Query: 663  NLANLPGYRVGGTIHIIVNNQIGFTTAPEYSRSSEYCTDVAKMIGAPIFHVNGDDPEACV 722
             L+ L G+RV GT+H I+NNQIGFTT P +SRSS Y +DVAKMI APIFHVNGDDPEA V
Sbjct: 420  GLSGLRGHRVAGTMHFIINNQIGFTTNPAFSRSSPYPSDVAKMIEAPIFHVNGDDPEAVV 479

Query: 723  WVARLAVDFRQRFKKDVVIDMLCYRRRGHNEGDDPSMTNPYVYDVVDTKRGARKSYTEAL 782
            + A++A ++R +F K VVIDM CYRR GHNEGD+P+ T P +Y V+   +   + Y + L
Sbjct: 480  YAAKVATEYRMKFHKPVVIDMFCYRRFGHNEGDEPAFTQPKMYKVIRGHKTVARIYADRL 539

Query: 783  IGRGDISMKEAEDALRDYQGQLERVFNEVRELEKH----------GVQPSESVESDQMIP 832
            I  G I+  + E    D++  LE+ F   +  + +          G++ +++ +  +   
Sbjct: 540  IAEGLITEGDFEKVKADWRAHLEQEFEAGQSYKPNKADWLDGQWSGLRAADNADEQRRGK 599

Query: 833  AGLATAVDKSLLARIGDAFLALPNGFTAHPRVQPVLEKRREMAYEGK-IDWAFGELLALG 891
             G    V    L  IG     +P GFTAH  +Q  +E R +M   G+ IDWA  E LA G
Sbjct: 600  TG----VPMKQLKEIGKKLSTIPEGFTAHRTIQRFMENRSQMIETGEGIDWAMAEALAFG 655

Query: 892  SLVAEGKLVRLSGQDSRRGTFSQRHSVLIDRHTGEEFTPLQLLATNSDGSPTGGKFLVYD 951
            SLV +G  +RLSGQD  RGTFSQRHSVL D+ T E + PL  LA      PT  ++ V +
Sbjct: 656  SLVVDGHKIRLSGQDCERGTFSQRHSVLYDQETEERYIPLANLA------PTQARYEVIN 709

Query: 952  SPLSEYAAVGFEYGYTVGNPDAVVLWEAQFGDFVNGAQSIIDEFISSGEAKWGQLSNVVL 1011
            S LSE A +GFEYGY++  P+A+ LWEAQFGDF NGAQ + D+FISSGE KW ++S +V 
Sbjct: 710  SMLSEEAVLGFEYGYSLARPNALTLWEAQFGDFANGAQVVFDQFISSGERKWLRMSGLVC 769

Query: 1012 LLPHGHEGQGPDHTSARIERFLQLWAEGSMTIAMPSTPSNYFHLLRRHALDGIQRPLIVF 1071
            LLPHG+EGQGP+H+SAR+ER+LQ+ AE +M +A  +TP+NYFH+LRR      ++PLI+ 
Sbjct: 770  LLPHGYEGQGPEHSSARLERWLQMCAEDNMQVANVTTPANYFHILRRQMKRDFRKPLILM 829

Query: 1072 TPKSMLRHKAAVSEIKDFT-EIKFRSVL--EEPTYEDG---IGDRNKVSRILLTSGKLYY 1125
            TPKS+LRHK A S + +   E  F  +L  +    +DG   +    K+ R+++ +GK+YY
Sbjct: 830  TPKSLLRHKRATSSLAELAGESSFHRLLWDDAEVIKDGPIKLQKDAKIRRVVMCTGKVYY 889

Query: 1126 ELAARKAKDNRNDLAIVRLEQLAPLPRRRLRETLDRYENVKEFFWVQEEPANQGAWPRFG 1185
            +L   + K   +D+ ++R+EQL P P + L   L R+ +  E  W QEEP N G+W    
Sbjct: 890  DLLEEREKRGIDDVYLLRVEQLYPFPAKALINELSRFRHA-EMVWCQEEPKNMGSWSFID 948

Query: 1186 LELPELLPD---KLAGIKRISRRAMSAPSSGSSKVHAVEQQEILDEAFG 1231
              L  +L     K   ++   R A ++P++G    H  +    L++A G
Sbjct: 949  PYLEWVLAHIDAKYQKVRYTGRPAAASPATGLMSKHLAQLAAFLEDALG 997



 Score = 40.0 bits (92), Expect = 1e-06
 Identities = 38/128 (29%), Positives = 51/128 (39%), Gaps = 20/128 (15%)

Query: 9   GQNEWLVEEMYRKFRDDPSSVDPSWHEFLVDYSPEPTSQPAAEPTRVTSPLVAERAAAAA 68
           G N   +E++Y ++ +DPSSV P W  F    S  P                 E    AA
Sbjct: 18  GANAAYIEQLYARYEEDPSSVSPEWQSFFKALSDNP-----------------EDVKKAA 60

Query: 69  PQAPPKPADTAAAGNG-VVAALAAKTAVPPPAEGDEVAVLRGAAAAVVKNMSASLEVPTA 127
             A  K A+     NG +V+AL    A    A   +V     A +A      +  EV  A
Sbjct: 61  KGASWKRANWPIPANGELVSALDGNWATVEKAIEKKVQAKAEAKSADTGKPVSEAEVLQA 120

Query: 128 T--SVRAV 133
           T  SVRA+
Sbjct: 121 TRDSVRAI 128