Pairwise Alignments
Query, 1582 a.a., Probable polyketide beta-ketoacyl synthase Pks4 from Mycobacterium tuberculosis H37Rv
Subject, 6891 a.a., SDR family NAD(P)-dependent oxidoreductase from Dickeya dianthicola ME23
Score = 131 bits (329), Expect = 3e-33
Identities = 80/231 (34%), Positives = 118/231 (51%), Gaps = 14/231 (6%)
Query: 1228 AVVPPEQVRTSRPDGAYLVTGGLGGLGLFLAGELAA-AGCGRIVLNSRSTPSPHATRVIE 1286
+ +PP + G YL+TGG GGLGL A E+A R++L RS +P +
Sbjct: 4866 SALPPLTCMPWKEQGVYLITGGTGGLGLIFATEIARQTRNSRLILTGRSAMNPRIQASLS 4925
Query: 1287 RLRAAGADIQVECGDIADAATAHRVVAVATASGLPVRGVLHAAAVVEDATLANVTDELID 1346
+L A GA + D+ D ++A TA + GVLH A V+ D+ + +
Sbjct: 4926 QLEALGAQVDYRTLDVCDRPGVEALIATVTAQYATINGVLHCAGVLRDSYILKKSAADFQ 4985
Query: 1347 RCWAPKVHGAWNIHRATAAQPLEWFCLFSSAAALVGSPGQGAYAAANSWLDAFAHWRRAQ 1406
APKV G N+ +A A PL++F LFSS AA +G+PGQ Y ANS++DA+AH+R+ Q
Sbjct: 4986 AVLAPKVQGVVNLDQALARHPLDFFILFSSTAAGLGNPGQADYVTANSFMDAYAHYRQQQ 5045
Query: 1407 GLPAT------SIAWGAWAEIGR------ATALAEGTG-AAIAPAEGARAF 1444
+ + +I W W E G T + + TG A++ G +AF
Sbjct: 5046 VVAQSRMGRTLAIDWPLWKEGGMKVDDAFETMMYQSTGMIAMSTDAGLQAF 5096
Score = 117 bits (293), Expect = 5e-29
Identities = 106/358 (29%), Positives = 161/358 (44%), Gaps = 36/358 (10%)
Query: 1246 VTGGLGGLGLFLAGELAAAGCGRIVLNSRSTPSPHATRVIERLRAAGADIQVECGDIADA 1305
+TGGLGG+G +A EL R+VL+ RS + + + + LR G ++ GD+AD
Sbjct: 3326 ITGGLGGIGYQIARELGTQYQARLVLSGRSALNERSEQRLLDLRHQGIEVTYLQGDVADP 3385
Query: 1306 ATAHRVVAVATASGLPVRGVLHAAAVVEDATLANVTD-ELIDRCWAPKVHGAWNIHRATA 1364
A +V + G++H+A ++ DA +AN T EL+D APKV G + AT
Sbjct: 3386 AQTRNLVEQILQDEGQLNGIIHSAGIIRDAFIANKTQAELLD-VLAPKVAGTLALDHATK 3444
Query: 1365 AQPLEWFCLFSSAAALVGSPGQGAYAAANSWLDAFAHWRR---AQGL---PATSIAWGAW 1418
L++ LFSS ++ G+ GQ YA AN ++D FA WR A GL ++ W W
Sbjct: 3445 DCNLDFMVLFSSLSSAFGNAGQADYACANGFMDGFALWRDQQVANGLRRGKTLTVNWPLW 3504
Query: 1419 AEIGR------ATALAEGTGAAIAP-AEGARAF---------QTLLRYGRAYSGYAPIMG 1462
+ G A L + TG P A G RA Q + YG A A +
Sbjct: 3505 RDGGMGISAPDAELLRQQTGLIPMPTAAGVRALMLGLQSQESQLAVIYGEAEKIQARL-- 3562
Query: 1463 TPWLTAFAQRSRFAEAFHATGQNQPATGKFLAELGSLPREEWPRTVRRLVSDQISLLLRR 1522
+ Q S H + N A E+ S R + + Q+ L +
Sbjct: 3563 -----SDGQTSTHPSPVHQSDINDAA--GLTHEVTSPVRVGQVCALLVSMVAQLQKLDEK 3615
Query: 1523 TIDPDRPLSDYGLDSLGNLELRTRIETETGIRVSPT---KITTVRGLAEHVCDELAAA 1577
I+ D LS YG +S+ E +R+ G+ + PT + +T+R + ++ D AA
Sbjct: 3616 KIELDMELSKYGFNSIDFTEFASRLNKTYGLALMPTVFFEHSTLRAMGNYLADTYPAA 3673
Score = 93.6 bits (231), Expect = 7e-22
Identities = 94/348 (27%), Positives = 144/348 (41%), Gaps = 36/348 (10%)
Query: 1242 GAYLVTGGLGGLGLFLAGELAAAGCGRIVLNSRSTPSPHATRVIERLRAAGADIQVECGD 1301
G YL+TGGLGGLG A L +++L RS + + G + D
Sbjct: 1525 GCYLITGGLGGLGTIFARYLCENFMAQVLLVGRSPLDLEKQANLRAIEQRGGQVTYLQAD 1584
Query: 1302 IADAATAHRVVAVATASGLPVRGVLHAAAVVEDATLANVTDELIDRCWAPKVHGAWNIHR 1361
+++ + + A G+ + G+LH A V LA + + APK+ G + +
Sbjct: 1585 VSELSQMQSLFADCQRKGIKINGILHTAGVQTTQLLAEKDLAGVRQVLAPKIQGTLVLDK 1644
Query: 1362 A-----TAAQPLEWFCLFSSAAALVGSPGQGAYAAANSWLDAFAHWRRAQGLPAT----- 1411
A A L++ FSS+AA++G G G YA AN + A+A+ R Q P +
Sbjct: 1645 AWQTVFGAEHALDFIVYFSSSAAVLGDFGAGDYAVANRFQMAYANNRSRQESPESKTPSL 1704
Query: 1412 -----SIAWGAWAEIGRATALAEGTGA-----------AIAPAEGARAFQTLLRYGRAYS 1455
+I W W + G AE A A+ EG R F+ LL G A S
Sbjct: 1705 IGKTIAINWPVWQDGGMTQRSAERVQATSLYLKTSGQRALRSEEGLRVFEQLLA-GEAGS 1763
Query: 1456 GYAPIMGTPWLTAFAQRSRFAEAFHAT--GQNQPATGKF-LAELGSLPREE---WPRTVR 1509
+ + E+ H Q+ PAT E+ L E+ W ++
Sbjct: 1764 SLVMVGQPDKIQRVLANGLQHESDHRQDGAQHPPATTTARRPEMQGLTVEQCVLW--ELQ 1821
Query: 1510 RLVSDQISLLLRRTIDPDRPLSDYGLDSLGNLELRTRIETETGIRVSP 1557
+ VSD +S + R + D L+D+G DS+ E + + I VSP
Sbjct: 1822 QAVSDTLS-IERHRLHHDVNLADFGFDSISLAEFASCLSRHWKIVVSP 1868
Score = 69.7 bits (169), Expect = 1e-14
Identities = 92/393 (23%), Positives = 148/393 (37%), Gaps = 69/393 (17%)
Query: 342 VADVHNAGAKVDFSVQYPD-GRLVDAPLPSWTHR-----TLMLSREDSHRSHTGAVQAVH 395
+AD + G ++D + P+ R V P + T LS H + GA Q++H
Sbjct: 2496 LADYYCQGYELDGAALSPEVSRCVVLPTYPFAREHHWVETRALSPSPDHIA--GARQSLH 2553
Query: 396 PLLGAHVHLLEEPERHVWQAGVGTGAHPWLGDHRIHNVAAFPGAAYCEMALAA---ARTT 452
PLL + L E +G +L DH+IH PG +Y EMA AA A T+
Sbjct: 2554 PLLKENASTLAELRFRA----EFSGEEFFLADHQIHGQKVLPGVSYLEMARAAYTYAATS 2609
Query: 453 LGELSEVRDIKFEQTLLLDEQTVVSSAATI------AAPGILQFAVESHQE--------- 497
+ S+ +Q L L TI G++ + + S E
Sbjct: 2610 VIPASQRPPFSVKQVLWLQPVVATQPTTTIYLGLYEQENGVIDYQIYSENEIQQRTIHGQ 2669
Query: 498 -------------GEPARRASAMLHALEEMPQPPGYDTNALTAAHESSMSGEELRKMFNS 544
R + LH L++ P Y AAH + F
Sbjct: 2670 GIIDPRLNDATTGNSAVERNTLDLHQLKKQMTGPEYQ-----AAH--------CYQQFRD 2716
Query: 545 LGIQYGPAFSGLVAVHTARGDVTTVLAEVALPGAIRSQQSAYASHPALLDACFQSV--LV 602
+G+ YG F G+ + T VLA +ALP S SA+ HP+L+DA Q+ L
Sbjct: 2717 MGLNYGETFQGIEQLLTGE---RQVLARIALPDTATS--SAFGLHPSLMDAALQTSLGLN 2771
Query: 603 HPEVQKATVGGLMLPVGVRRLRNYHSTRSAHYCLARVTSSSRAGECEA---DLDVFDQAG 659
H + G +P + +L + + + R+ S+ + + D+D+ + G
Sbjct: 2772 HSGLPS---GAAYVPFALEQLEVFAEVDTRLWVWLRLVSTENSANEQVRKMDIDLCNDHG 2828
Query: 660 TVLLTVEGLRLAAGISEHERANRVFDERLLTIE 692
+ +++ G H VF ++E
Sbjct: 2829 RICVSLRGFSTRILPVSHSAEEPVFPGTATSVE 2861
Score = 62.4 bits (150), Expect = 2e-12
Identities = 69/294 (23%), Positives = 113/294 (38%), Gaps = 26/294 (8%)
Query: 331 GEQLPFGLRGFVADVHNAGAKVDFSVQYPDG---RLVDAPLPSWTHRTLMLSREDSHRSH 387
G L G + DV G +VD+ +YP R + P + L S R
Sbjct: 4321 GTWLQTGNYNKLLDVWVKGGQVDWKQRYPTAIKPRRIGLPTYPFARDRFWLKVTTSERGS 4380
Query: 388 TGAVQAVHPL------LGAHVHLLEEPERHVWQAGVGTGAHPWLGDHRIHNVAAFPGAAY 441
+ A P+ L VH + G +L DH++ PG AY
Sbjct: 4381 NESGTAESPVKISPYRLHPLVHRNTSDITALCFTSWFDGREFFLADHQVMGQKLLPGVAY 4440
Query: 442 CEMALAAARTTLG---ELSEVRDIKFEQTLLLDEQTVVSSAATI--------AAPGILQF 490
EMA AA +G L + + + +T +SA T + +++F
Sbjct: 4441 LEMARAAVEQVVGVGLHLQLTQIVWVRPFVAEHPETSATSAGTYPLTVKLLPQSTKVIRF 4500
Query: 491 AVES-HQEGEPARRASAMLHALEEMPQP-PGYDTNALTAAH-ESSMSGEELRKMFNSLGI 547
+ S +G+ + ++ P D + A H + ++ E + F LGI
Sbjct: 4501 EIGSLLPDGQTQTHCQGNVLVMDSRPDDRERLDLSVALAEHQDGTIDKAECYQAFRQLGI 4560
Query: 548 QYGPAFSGLVAVHTARGDVTTVLAEVALPGAIRSQQSAYASHPALLDACFQSVL 601
YGP G+ ++ A+G VLA ++LP + Y HP+L+D+ Q+ L
Sbjct: 4561 VYGPGHQGIERLYLAKG---RVLARLSLPETLSETLGDYVLHPSLMDSALQATL 4611