Pairwise Alignments
Query, 1582 a.a., Probable polyketide beta-ketoacyl synthase Pks4 from Mycobacterium tuberculosis H37Rv
Subject, 6897 a.a., SDR family NAD(P)-dependent oxidoreductase from Dickeya dianthicola 67-19
Score = 132 bits (331), Expect = 2e-33
Identities = 80/231 (34%), Positives = 116/231 (50%), Gaps = 14/231 (6%)
Query: 1228 AVVPPEQVRTSRPDGAYLVTGGLGGLGLFLAGELAA-AGCGRIVLNSRSTPSPHATRVIE 1286
+ +PP + G YL+TGG GGLGL A E+A R++L RS +P +
Sbjct: 4869 SALPPLTCMPWKEQGVYLITGGAGGLGLIFATEIARQTRNSRLILTGRSAMNPRIQASLN 4928
Query: 1287 RLRAAGADIQVECGDIADAATAHRVVAVATASGLPVRGVLHAAAVVEDATLANVTDELID 1346
+L A GA + D+ D ++A TA + GVLH A V+ D + +
Sbjct: 4929 QLAALGAQVDYRTLDVCDRPGVEALIATVTAQYATINGVLHCAGVLRDGYILKKSAADFQ 4988
Query: 1347 RCWAPKVHGAWNIHRATAAQPLEWFCLFSSAAALVGSPGQGAYAAANSWLDAFAHWRRAQ 1406
APKV G N+ +A A PL++F LFSS AA +G+PGQ Y ANS++DA+AH+R+ Q
Sbjct: 4989 AVLAPKVQGVVNLDQALARHPLDFFILFSSTAAGLGNPGQADYVTANSFMDAYAHYRQQQ 5048
Query: 1407 GLPAT------SIAWGAWAEIGR------ATALAEGTGAAIAPAE-GARAF 1444
+ + +I W W E G T + + TG P + G +AF
Sbjct: 5049 VVAQSRMGRTLAINWPLWKEGGMKVDDAFETMMYQSTGMIAMPTDAGLQAF 5099
Score = 122 bits (306), Expect = 1e-30
Identities = 104/364 (28%), Positives = 165/364 (45%), Gaps = 48/364 (13%)
Query: 1246 VTGGLGGLGLFLAGELAAAGCGRIVLNSRSTPSPHATRVIERLRAAGADIQVECGDIADA 1305
+TGGLGG+G +A EL R+VL+ RS + + + + LR G ++ GD+AD
Sbjct: 3338 ITGGLGGIGYQIARELGTQHQARLVLSGRSALNERSEQRLLDLRHQGIEVTYLQGDVADP 3397
Query: 1306 ATAHRVVAVATASGLPVRGVLHAAAVVEDATLANVTD-ELIDRCWAPKVHGAWNIHRATA 1364
A +V + G++H+A ++ DA +AN T EL+D APKV G + AT
Sbjct: 3398 AQTRNLVQQILQDEGQLNGIIHSAGIIRDAFIANKTQAELLD-VLAPKVAGTLALDHATQ 3456
Query: 1365 AQPLEWFCLFSSAAALVGSPGQGAYAAANSWLDAFAHWRR---AQGL---PATSIAWGAW 1418
L++ LFSS ++ G+ GQ YA AN ++D FA WR A GL ++ W W
Sbjct: 3457 DCNLDFMVLFSSLSSAFGNAGQADYACANGFMDGFALWRDQQVADGLRRGKTLTVNWPLW 3516
Query: 1419 AEIGR------ATALAEGTGAAIAPAEG----------ARAFQTLLRYGRAYSGYAPIMG 1462
+ G A L + TG P E ++ Q + YG A A +
Sbjct: 3517 RDGGMGISAPDAELLRQQTGLIPMPTEAGIQALMLGLQSQESQLAVIYGEAEKIQARL-- 3574
Query: 1463 TPWLTAFAQRSRFAEAFHATGQNQPATGKFLAELGSLPREEWPRTVRRLVSDQISLLLR- 1521
+ Q S H +G N A G +P P V ++ + +S++ +
Sbjct: 3575 -----SAGQTSTHPSPVHQSGINDAA--------GLIPEVTSPVRVGQVYALLVSMVAQL 3621
Query: 1522 -----RTIDPDRPLSDYGLDSLGNLELRTRIETETGIRVSPT---KITTVRGLAEHVCDE 1573
+ I+ D LS YG +S+ E +R+ G+ + PT + +T+R + ++ D
Sbjct: 3622 QKLDEKKIELDMELSKYGFNSIDFTEFASRLNKTYGLALMPTVFFEHSTLRAMGNYLADT 3681
Query: 1574 LAAA 1577
AA
Sbjct: 3682 YPAA 3685
Score = 92.4 bits (228), Expect = 2e-21
Identities = 93/348 (26%), Positives = 144/348 (41%), Gaps = 36/348 (10%)
Query: 1242 GAYLVTGGLGGLGLFLAGELAAAGCGRIVLNSRSTPSPHATRVIERLRAAGADIQVECGD 1301
G YL+TGGLGGLG A L +++L RS + + G + D
Sbjct: 1537 GCYLITGGLGGLGTVFARYLCENFMAQVLLVGRSPLDLEKQANLRAIEQRGGQVTYLQAD 1596
Query: 1302 IADAATAHRVVAVATASGLPVRGVLHAAAVVEDATLANVTDELIDRCWAPKVHGAWNIHR 1361
+++ + + A G+ + G+LH A V LA + + APK+ G +
Sbjct: 1597 VSELSQMQSLFADCQRKGIKINGILHTAGVQTTQLLAEKDLAGVRQVLAPKIQGTLVLDT 1656
Query: 1362 A-----TAAQPLEWFCLFSSAAALVGSPGQGAYAAANSWLDAFAHWRRAQGLP------- 1409
A A L++ FSS+AA++G G G YA AN + A+A+ R Q P
Sbjct: 1657 AWQTVFGAEHALDFIVYFSSSAAVLGDFGAGDYAVANRFQMAYANNRGRQESPEGKTPSL 1716
Query: 1410 ---ATSIAWGAWAEIGRATALAEGTGA-----------AIAPAEGARAFQTLLRYGRAYS 1455
+I+W W + G AE A A+ EG R F+ LL G A S
Sbjct: 1717 IGKTIAISWPVWQDGGMTQRSAERVQATSLYLKTSGQRALRSEEGLRVFEQLLA-GEAGS 1775
Query: 1456 GYAPIMGTPWLTAFAQRSRFAEAFHAT--GQNQPATGKF-LAELGSLPREE---WPRTVR 1509
+ + E+ H Q+ PAT ++ L E+ W ++
Sbjct: 1776 SLVMVGQPDKIQRVLANGLQHESNHRQDGSQHPPATTTARRPDMQGLTVEQCVLW--ELQ 1833
Query: 1510 RLVSDQISLLLRRTIDPDRPLSDYGLDSLGNLELRTRIETETGIRVSP 1557
+ VSD +S + R + D L+D+G DS+ E + + + I VSP
Sbjct: 1834 QAVSDTLS-IERHRLHHDVNLADFGFDSISLAEFASCLSRKWNIVVSP 1880
Score = 65.9 bits (159), Expect = 2e-13
Identities = 78/340 (22%), Positives = 127/340 (37%), Gaps = 61/340 (17%)
Query: 389 GAVQAVHPLLGAHVHLLEEPERHVWQAGVGTGAHPWLGDHRIHNVAAFPGAAYCEMALAA 448
GA ++HPLL + L E +G +L DH+IH PG +Y EMA AA
Sbjct: 2559 GARPSLHPLLKENASTLAELRFRA----EFSGEEFFLADHQIHGQKVLPGVSYLEMARAA 2614
Query: 449 ---ARTTLGELSEVRDIKFEQTLLLDEQTVVSSAATI------AAPGILQFAVESHQE-- 497
A ++ S+ +Q L L T+ G++ + + S E
Sbjct: 2615 YTYAAASVIPASQRLPFSVKQVLWLQPVVATQPITTLYLGLYEQENGVIDYQIYSENEIQ 2674
Query: 498 --------------------GEPARRASAMLHALEEMPQPPGYDTNALTAAHESSMSGEE 537
R + LH L++ P Y AAH
Sbjct: 2675 QRTIHGQGIIDPRLNDATTGNSAVERNTLDLHQLKKQMTGPEYQ-----AAH-------- 2721
Query: 538 LRKMFNSLGIQYGPAFSGLVAVHTARGDVTTVLAEVALPGAIRSQQSAYASHPALLDACF 597
+ F +G+ YG F G+ + T VLA +ALP S SA+ HP+L+DA
Sbjct: 2722 CYQRFREMGLNYGETFQGIEQLLTGE---RQVLARIALPDTATS--SAFGLHPSLMDAAL 2776
Query: 598 QSV--LVHPEVQKATVGGLMLPVGVRRLRNYHSTRSAHYCLARVTSSSRAGECEA---DL 652
Q+ L H + G +P + +L + + + R+ S+ + + D+
Sbjct: 2777 QTSLGLNHSGLPS---GAAYVPFALEQLEVFAEVDTHLWVWLRLVSTENSANEQVQKMDI 2833
Query: 653 DVFDQAGTVLLTVEGLRLAAGISEHERANRVFDERLLTIE 692
D+ D G + +++ G H VF +++E
Sbjct: 2834 DLCDDHGRICVSLRGFSTRMLPVSHTAEEAVFPGTAMSVE 2873
Score = 62.4 bits (150), Expect = 2e-12
Identities = 70/300 (23%), Positives = 117/300 (39%), Gaps = 34/300 (11%)
Query: 329 RRGEQLPFGLRGFVADVHNAGAKVDFSVQYPDG---RLVDAPLPSWTHRTLMLSREDSHR 385
R G L G + DV G +VD+ +YP R + P + L S R
Sbjct: 4322 RVGTWLQTGNYNKLLDVWVKGGQVDWKQRYPTAIKPRRIGLPTYPFARDRFWLKVTTSER 4381
Query: 386 SHTGAVQAVHPL------LGAHVHLLEEPERHVWQAGVGTGAHPWLGDHRIHNVAAFPGA 439
+ A P+ L VH + G +L DH++ PG
Sbjct: 4382 GSNESGTAESPVKISPYRLHPLVHRNTSDITALCFTSWFDGREFFLADHQVMGQKLLPGV 4441
Query: 440 AYCEMALAAARTTLG-----ELSEVRDIKFEQTLLLDEQTVVSSAATIAAPGILQFAVES 494
AY EMA AA +G +L+++ ++ + E S+ + A P ++ +S
Sbjct: 4442 AYLEMARAAVEQVVGVGLHLQLTQIVWVR----PFVAEHPETSATSAGAYPLTVKLLPQS 4497
Query: 495 HQ-----------EGEPARRASAMLHALEEMPQP-PGYDTNALTAAH-ESSMSGEELRKM 541
Q +G+ + ++ P D + A H + ++ E +
Sbjct: 4498 AQVIRFEIGSLLPDGQTQTHCQGNVLVMDSRPDDRERLDLSVALAEHQDGTIDKAECYQA 4557
Query: 542 FNSLGIQYGPAFSGLVAVHTARGDVTTVLAEVALPGAIRSQQSAYASHPALLDACFQSVL 601
F LGI YGP G+ ++ A+G VLA ++LP + + Y HP+L+D+ Q+ L
Sbjct: 4558 FRQLGIVYGPGHQGIEKLYLAKG---RVLARLSLPETLSETLNDYVLHPSLMDSALQATL 4614