Pairwise Alignments
Query, 1194 a.a., Probable transmembrane multidrug efflux pump from Mycobacterium tuberculosis H37Rv
Subject, 595 a.a., lipid A export permease/ATP-binding protein MsbA from Magnetospirillum magneticum AMB-1
Score = 280 bits (716), Expect = 2e-79
Identities = 190/560 (33%), Positives = 288/560 (51%), Gaps = 14/560 (2%)
Query: 25 GAALAGTVIAVLVPLVTKRVIDDAIAADHRP--LAPWAVVLVAAAGATYLLMYVRRYYGG 82
GAA ++ P+V K I + RP L P A+ ++ + Y +
Sbjct: 41 GAAANAGYALLMDPVVNK------IFTEKRPEFLLPLALAVLGTFAVKSVCNYGEAVFLS 94
Query: 83 RIAHLVQHDLRMDAFQALLRWDGRQQDRWSSGQLIVRTTNDLQLVQALLFD-VPNVLRHV 141
++ V D++ F L+R D S+G+++ R TND+ ++ + D + +
Sbjct: 95 KVGLRVIADMQSRLFAHLMRLDVAFFHANSTGRILSRLTNDISQMRFAVSDALTGAGKDA 154
Query: 142 LTLLLGVAVMTWLSVPLALLAVLLVPVIGLIAHRSRRLLAAATHCAQEHKAAVTGVVDAA 201
+++ + M + L+ + P+ L + R + T QEH +T ++ A
Sbjct: 155 SSVIFLIGAMFYQDWRLSAWTFFIFPIAILPIRKLGRRMRKVTANTQEHMGQLTTYLEQA 214
Query: 202 VCGIRVVKAFGQEERETVKLVTASRALYAAQLRVARLNAHFGPLLQTLPALGQMAVFALG 261
V GIRVVKA+G EE E K+ L + AR+ + P+++ L + V G
Sbjct: 215 VQGIRVVKAYGMEEYEKRKVGALVEMLQDLIYKAARVRSASSPIMELLGGIAITVVILYG 274
Query: 262 GWMAAQGSITVGTFVAFWACLTLLARPACDLAGMLTIAQQARAGAVRVLELIDSRPTLV- 320
G G T G F +F L L RP LA M T Q+ A A R ++D++PT+
Sbjct: 275 GTRVVNGETTPGAFFSFITALMLAYRPIKSLAAMNTNLQEGLAAASRTFSVLDTQPTIFE 334
Query: 321 -DGTKPLSPEARLSLEFQRVSFGYVADRPVLREISLSVRAGETLAVVGAPGSGKSTLASL 379
DG L ++ F+ V F Y + VL I L+V G+T+A+VG G+GKST+ +L
Sbjct: 335 KDGAADLVV-LEGNVSFEGVFFTYDGSKAVLDGIDLAVPGGKTVALVGPSGAGKSTVLNL 393
Query: 380 ATRCYDVTQGAVRIGGQDVRELTLDSLRSAIGLVPEDAVLFSGTIGANIAYGRPDATPEQ 439
R YDVT G V + GQDVR ++L SLRS I LV ++ LF +I ANIAYGR AT E+
Sbjct: 394 LPRFYDVTDGHVLVDGQDVRNVSLSSLRSKIALVSQEITLFDDSIRANIAYGRFGATDEE 453
Query: 440 IATAARAAHIEEFVNTLPDGYQTAVGARGLTLSGGQRQRIALARALLHQPRLLIMDDPTS 499
I AAR+A +F+ +LP+GY T VG RGL LSGGQRQR+A+ARA+L +L++D+ TS
Sbjct: 454 IEAAARSAAAHDFIVSLPEGYDTVVGERGLNLSGGQRQRLAIARAMLKNAPILLLDEATS 513
Query: 500 AVDAVIECGIQEVLREAIADRTAVIFTRRRSMLTLADRVAVLDSGRLLDVGTPDEVWERC 559
A+D E +Q L + RT ++ R S + AD + VLD GR+++ G + + +
Sbjct: 514 ALDTESERQVQTALELLMRGRTTIVIAHRLSTVVNADLIHVLDKGRVIESGDHNALMAKN 573
Query: 560 PRYRELLSPAPDLADDLVVA 579
Y L A A++ V A
Sbjct: 574 GTYARLY--AMQFAEEAVKA 591
Score = 270 bits (691), Expect = 2e-76
Identities = 181/514 (35%), Positives = 269/514 (52%), Gaps = 9/514 (1%)
Query: 668 ALAGTATVVIRWVVQWGSAMVAGYTGEQVLFRLRSVVFAHAQRLGLDAFEDDGDAQIVTA 727
ALA T ++ V +G A+ G +V+ ++S +FAH RL + F + +I++
Sbjct: 72 ALAVLGTFAVKSVCNYGEAVFLSKVGLRVIADMQSRLFAHLMRLDVAFFHANSTGRILSR 131
Query: 728 VTADVEAI---VAFLRTGLVVAVISVVTLVGILVALLAIRARLVLLIFTTMPVLALATWQ 784
+T D+ + V+ TG SV+ L+G A+ RL F P+ L +
Sbjct: 132 LTNDISQMRFAVSDALTGAGKDASSVIFLIG---AMFYQDWRLSAWTFFIFPIAILPIRK 188
Query: 785 FRRASNWTYRRARHRLGTVTATLREYAAGLRIAQAFRAEYRGLQSYFAHSDDYRRLGVRG 844
R + +G +T L + G+R+ +A+ E + A + + L +
Sbjct: 189 LGRRMRKVTANTQEHMGQLTTYLEQAVQGIRVVKAYGMEEYEKRKVGALVEMLQDLIYKA 248
Query: 845 QRLLALYYPFVALLCSLATTLVLLDGAREVRAGVISVGALVTYLLYIELLYTPIGELAQM 904
R+ + P + LL +A T+V+L G V G + GA +++ + L Y PI LA M
Sbjct: 249 ARVRSASSPIMELLGGIAITVVILYGGTRVVNGETTPGAFFSFITALMLAYRPIKSLAAM 308
Query: 905 FDDYQRAAVAAGRIRSLLSTRTP--SSPAARPVGTLRGEVVFDAVHYSYRTREVPALAGI 962
+ Q AA R S+L T+ A + L G V F+ V ++Y + L GI
Sbjct: 309 NTNLQEGLAAASRTFSVLDTQPTIFEKDGAADLVVLEGNVSFEGVFFTYDGSKA-VLDGI 367
Query: 963 NLRIPAGQTVVFVGSTGSGKSTLIKLVARFYDPTHGTVRVDGCDLREFDVDGYRNRLGIV 1022
+L +P G+TV VG +G+GKST++ L+ RFYD T G V VDG D+R + R+++ +V
Sbjct: 368 DLAVPGGKTVALVGPSGAGKSTVLNLLPRFYDVTDGHVLVDGQDVRNVSLSSLRSKIALV 427
Query: 1023 TQEQYVFAGTVRDAIAYGRPDATDAQVERAAREVGAHPMITALDNGYLHQVTAGGRNLSA 1082
+QE +F ++R IAYGR ATD ++E AAR AH I +L GY V G NLS
Sbjct: 428 SQEITLFDDSIRANIAYGRFGATDEEIEAAARSAAAHDFIVSLPEGYDTVVGERGLNLSG 487
Query: 1083 GQLQLLALARARLVDPDILLLDEATVALDPATEAVVQRATLTLAARRTTLIVAHGLAIAE 1142
GQ Q LA+ARA L + ILLLDEAT ALD +E VQ A L RTT+++AH L+
Sbjct: 488 GQRQRLAIARAMLKNAPILLLDEATSALDTESERQVQTALELLMRGRTTIVIAHRLSTVV 547
Query: 1143 HADRIVVLEHGTVVEDGAHTELLAAGGHYSRLWA 1176
+AD I VL+ G V+E G H L+A G Y+RL+A
Sbjct: 548 NADLIHVLDKGRVIESGDHNALMAKNGTYARLYA 581