Pairwise Alignments

Query, 1194 a.a., Probable transmembrane multidrug efflux pump from Mycobacterium tuberculosis H37Rv

Subject, 589 a.a., SmdA family multidrug ABC transporter permease/ATP-binding protein from Erwinia tracheiphila SCR3

 Score =  267 bits (682), Expect = 2e-75
 Identities = 187/543 (34%), Positives = 282/543 (51%), Gaps = 14/543 (2%)

Query: 32  VIAVLVPLVTKRVIDDAIA--ADHRPLAPWAVVLVAAAGATYLLMYVRRYYGGRIAHLVQ 89
           ++ +L P V   ++DD          L  W  ++   A   Y L YV R      ++ + 
Sbjct: 30  LLQLLPPKVVGTIVDDVTQQQTSGMGLMLWVALMFFTAVLIYFLRYVWRILLFGASYQLA 89

Query: 90  HDLRMDAFQALLRWDGRQQDRWSSGQLIVRTTNDLQLVQALLFDVPNVLRHVLTLLLGVA 149
            +LR D ++ L R       R  +G LI R TND+  V     +   VL  V +L++G+A
Sbjct: 90  VELRRDFYRQLSRQHPEFYLRHRTGDLIARATNDVDRVVFAAGE--GVLTLVDSLVMGLA 147

Query: 150 VM----TWLSVPLALLAVLLVPVIGLIAHRSRRLLAAATHCAQEHKAAVTGVVDAAVCGI 205
           V+    T +S  L LLA+L +PV+ ++  R    L      AQ   +++      ++  I
Sbjct: 148 VLVVMSTQISWQLTLLALLPMPVMAIVIKRYGEQLHQRFRLAQAAFSSLNDQTQESLTSI 207

Query: 206 RVVKAFGQEERETVKLVTASRALYAAQLRVARLNAHFGPLLQTLPALGQMAVFALGG--W 263
           R++KAFG E  ++ K    +       LRVAR++A F P +    A+G   + A+GG  W
Sbjct: 208 RMIKAFGLENHQSAKFAEIAEDTGNKNLRVARVDARFDPTIYI--AIGMSNLLAVGGGSW 265

Query: 264 MAAQGSITVGTFVAFWACLTLLARPACDLAGMLTIAQQARAGAVRVLELIDSRPTLVDGT 323
           +   G +T+G   +F   L L+  P   LA M  I ++  A  VR+  L+   PT+ DG+
Sbjct: 266 LVWHGEMTLGQLTSFVMYLGLMIWPMLALAWMFNIVERGSAAWVRIAPLLAEVPTVKDGS 325

Query: 324 KPLSPEARLSLEFQRVSFGYV-ADRPVLREISLSVRAGETLAVVGAPGSGKSTLASLATR 382
           + L P+ R  L+     F Y  A +P LR+++ S++ GE L + G  G+GKSTL  L  R
Sbjct: 326 ETL-PKERGQLQIAIREFFYPGAKQPALRQLNASLKPGEMLGLCGPTGAGKSTLLGLIQR 384

Query: 383 CYDVTQGAVRIGGQDVRELTLDSLRSAIGLVPEDAVLFSGTIGANIAYGRPDATPEQIAT 442
            +D+ QG +R  G  +  L LDS RS I +V +  +LFS ++  NIA GRP A+   I  
Sbjct: 385 HFDIGQGDIRYHGIPLSSLRLDSWRSRIAVVSQTPLLFSDSVSNNIALGRPAASRSDIEQ 444

Query: 443 AARAAHIEEFVNTLPDGYQTAVGARGLTLSGGQRQRIALARALLHQPRLLIMDDPTSAVD 502
           AAR A++ + +  LP GY T VG RG+ LSGGQ+QRI++ARALL    +LI+DD  SAVD
Sbjct: 445 AARLANVHDDIMQLPQGYDTEVGERGVMLSGGQKQRISIARALLLNAEILILDDALSAVD 504

Query: 503 AVIECGIQEVLREAIADRTAVIFTRRRSMLTLADRVAVLDSGRLLDVGTPDEVWERCPRY 562
              E  I + LR   A RT +I   R S L  A  + V+  G +   G   E+ E+   Y
Sbjct: 505 GRTEYQILQNLRWWRAGRTIIISAHRLSALNEASEILVMQKGTVSQRGQHSELMEQNGWY 564

Query: 563 REL 565
           +++
Sbjct: 565 QDM 567



 Score =  214 bits (546), Expect = 1e-59
 Identities = 154/559 (27%), Positives = 275/559 (49%), Gaps = 5/559 (0%)

Query: 620  LREFRGPLALSLLLVAVQTCAGLLPPLLIRHGIDVGIRRHV--LSALWWAALAGTATVVI 677
            +RE+R  L    LL+ +     LLPP ++   +D   ++    +  + W AL     V+I
Sbjct: 12   IREWRRYLGAVFLLIIIALLQ-LLPPKVVGTIVDDVTQQQTSGMGLMLWVALMFFTAVLI 70

Query: 678  RWVVQWGSAMVAGYTGEQVLFRLRSVVFAHAQRLGLDAFEDDGDAQIVTAVTADVEAIVA 737
             ++      ++ G    Q+   LR   +    R   + +       ++   T DV+ +V 
Sbjct: 71   YFLRYVWRILLFG-ASYQLAVELRRDFYRQLSRQHPEFYLRHRTGDLIARATNDVDRVVF 129

Query: 738  FLRTGLVVAVISVVTLVGILVALLA-IRARLVLLIFTTMPVLALATWQFRRASNWTYRRA 796
                G++  V S+V  + +LV +   I  +L LL    MPV+A+   ++    +  +R A
Sbjct: 130  AAGEGVLTLVDSLVMGLAVLVVMSTQISWQLTLLALLPMPVMAIVIKRYGEQLHQRFRLA 189

Query: 797  RHRLGTVTATLREYAAGLRIAQAFRAEYRGLQSYFAHSDDYRRLGVRGQRLLALYYPFVA 856
            +    ++    +E    +R+ +AF  E      +   ++D     +R  R+ A + P + 
Sbjct: 190  QAAFSSLNDQTQESLTSIRMIKAFGLENHQSAKFAEIAEDTGNKNLRVARVDARFDPTIY 249

Query: 857  LLCSLATTLVLLDGAREVRAGVISVGALVTYLLYIELLYTPIGELAQMFDDYQRAAVAAG 916
            +   ++  L +  G+  V  G +++G L ++++Y+ L+  P+  LA MF+  +R + A  
Sbjct: 250  IAIGMSNLLAVGGGSWLVWHGEMTLGQLTSFVMYLGLMIWPMLALAWMFNIVERGSAAWV 309

Query: 917  RIRSLLSTRTPSSPAARPVGTLRGEVVFDAVHYSYRTREVPALAGINLRIPAGQTVVFVG 976
            RI  LL+        +  +   RG++      + Y   + PAL  +N  +  G+ +   G
Sbjct: 310  RIAPLLAEVPTVKDGSETLPKERGQLQIAIREFFYPGAKQPALRQLNASLKPGEMLGLCG 369

Query: 977  STGSGKSTLIKLVARFYDPTHGTVRVDGCDLREFDVDGYRNRLGIVTQEQYVFAGTVRDA 1036
             TG+GKSTL+ L+ R +D   G +R  G  L    +D +R+R+ +V+Q   +F+ +V + 
Sbjct: 370  PTGAGKSTLLGLIQRHFDIGQGDIRYHGIPLSSLRLDSWRSRIAVVSQTPLLFSDSVSNN 429

Query: 1037 IAYGRPDATDAQVERAAREVGAHPMITALDNGYLHQVTAGGRNLSAGQLQLLALARARLV 1096
            IA GRP A+ + +E+AAR    H  I  L  GY  +V   G  LS GQ Q +++ARA L+
Sbjct: 430  IALGRPAASRSDIEQAARLANVHDDIMQLPQGYDTEVGERGVMLSGGQKQRISIARALLL 489

Query: 1097 DPDILLLDEATVALDPATEAVVQRATLTLAARRTTLIVAHGLAIAEHADRIVVLEHGTVV 1156
            + +IL+LD+A  A+D  TE  + +      A RT +I AH L+    A  I+V++ GTV 
Sbjct: 490  NAEILILDDALSAVDGRTEYQILQNLRWWRAGRTIIISAHRLSALNEASEILVMQKGTVS 549

Query: 1157 EDGAHTELLAAGGHYSRLW 1175
            + G H+EL+   G Y  ++
Sbjct: 550  QRGQHSELMEQNGWYQDMY 568