Pairwise Alignments
Query, 1194 a.a., Probable transmembrane multidrug efflux pump from Mycobacterium tuberculosis H37Rv
Subject, 583 a.a., lipid A ABC transporter ATP-binding protein/permease MsbA from Erwinia tracheiphila SCR3
Score = 259 bits (661), Expect = 6e-73
Identities = 163/557 (29%), Positives = 282/557 (50%), Gaps = 1/557 (0%)
Query: 619 LLREFRGPLALSLLLVAVQTCAGLLPPLLIRHGIDVGIRRHVLSALWWAALAGTATVVIR 678
+++ F+ + +S + + + +L L++ +D G + S L W LA +++R
Sbjct: 19 MIKPFKTGIIVSSVALVINAAGDVLMMSLLKPLLDDGFGKADPSVLLWMPLAVIGLMLVR 78
Query: 679 WVVQWGSAMVAGYTGEQVLFRLRSVVFAHAQRLGLDAFEDDGDAQIVTAVTADVEAIVAF 738
V + S+ + V+ +R +F+H + + F+ +++ +T D E + +
Sbjct: 79 GVTSYISSYFISWVSGNVVMSMRRRLFSHMMGMPVAFFDQQSTGTLLSRITYDSEQVASS 138
Query: 739 LRTGLVVAVISVVTLVGILVALLAIRARLVLLIFTTMPVLALATWQFRRASNWTYRRARH 798
+ LV V ++VG+ V + +L +++ PV++ A + + ++
Sbjct: 139 SSSALVTVVREGASIVGLFVMMFYYSWQLSIILIVLAPVVSFAIRYVSKRFRNISKNMQN 198
Query: 799 RLGTVTATLREYAAGLRIAQAFRAEYRGLQSYFAHSDDYRRLGVRGQRLLALYYPFVALL 858
+G VT + + G + F + + + S+ R+ G++ ++ P + L+
Sbjct: 199 TMGQVTTSAEQMLKGHKEVLIFGGQEIESERFDRVSNRMRQQGMKLVSASSISDPIIQLI 258
Query: 859 CSLATTLVLLDGAREVRAGVISVGALVTYLLYIELLYTPIGELAQMFDDYQRAAVAAGRI 918
SLA +L + ++ G + + L P+ L + +QR A +
Sbjct: 259 ASLALAFILYAASFPSVMQTLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTL 318
Query: 919 RSLLSTRTPSSPAARPVGTLRGEVVFDAVHYSYRTREVPALAGINLRIPAGQTVVFVGST 978
S+L ++ + +R + +G+V F V ++Y R+VPAL INL IP G+TV VG +
Sbjct: 319 FSILDSKQETDSGSRTIERAKGDVEFRQVTFTYPGRDVPALQNINLSIPEGKTVALVGRS 378
Query: 979 GSGKSTLIKLVARFYDPTHGTVRVDGCDLREFDVDGYRNRLGIVTQEQYVFAGTVRDAIA 1038
GSGKST+ L+ RFYD G + +DG DLRE+ + RN++ +V+Q ++F TV + IA
Sbjct: 379 GSGKSTIASLMTRFYDIQQGEILIDGHDLREYTLRSLRNQVALVSQNVHLFNDTVANNIA 438
Query: 1039 YGRPDATDAQ-VERAAREVGAHPMITALDNGYLHQVTAGGRNLSAGQLQLLALARARLVD 1097
Y R + + +E+AA A I +DNG + G LS GQ Q +A+ARA L D
Sbjct: 439 YARAEHYSREDIEKAAIMAHAMDFIKKMDNGLDTVIGENGVLLSGGQRQRIAIARALLRD 498
Query: 1098 PDILLLDEATVALDPATEAVVQRATLTLAARRTTLIVAHGLAIAEHADRIVVLEHGTVVE 1157
IL+LDEAT ALD +E +Q A L RT+L++AH L+ E AD IVV+E G +VE
Sbjct: 499 CPILILDEATSALDTESEHAIQAALDELQKNRTSLVIAHRLSTIEKADEIVVVEDGHIVE 558
Query: 1158 DGAHTELLAAGGHYSRL 1174
G+H LLA G Y++L
Sbjct: 559 RGSHKVLLAHKGAYAQL 575
Score = 231 bits (588), Expect = 2e-64
Identities = 159/524 (30%), Positives = 271/524 (51%), Gaps = 11/524 (2%)
Query: 35 VLVPLVTKRVIDDAIA-ADHRPLA--PWAVV-LVAAAGATYLLMYVRRYYGGRIAHLVQH 90
VL+ + K ++DD AD L P AV+ L+ G T Y+ Y+ ++ V
Sbjct: 42 VLMMSLLKPLLDDGFGKADPSVLLWMPLAVIGLMLVRGVT---SYISSYFISWVSGNVVM 98
Query: 91 DLRMDAFQALLRWDGRQQDRWSSGQLIVRTTNDL-QLVQALLFDVPNVLRHVLTLLLGVA 149
+R F ++ D+ S+G L+ R T D Q+ + + V+R +++
Sbjct: 99 SMRRRLFSHMMGMPVAFFDQQSTGTLLSRITYDSEQVASSSSSALVTVVREGASIVGLFV 158
Query: 150 VMTWLSVPLALLAVLLVPVIGLIAHRSRRLLAAATHCAQEHKAAVTGVVDAAVCGIRVVK 209
+M + S L+++ ++L PV+ + + Q VT + + G + V
Sbjct: 159 MMFYYSWQLSIILIVLAPVVSFAIRYVSKRFRNISKNMQNTMGQVTTSAEQMLKGHKEVL 218
Query: 210 AFGQEERETVKLVTASRALYAAQLRVARLNAHFGPLLQTLPALGQMAVFALGGWMAAQGS 269
FG +E E+ + S + +++ ++ P++Q + +L + + + +
Sbjct: 219 IFGGQEIESERFDRVSNRMRQQGMKLVSASSISDPIIQLIASLALAFILYAASFPSVMQT 278
Query: 270 ITVGTFVAFWACLTLLARPACDLAGMLTIAQQARAGAVRVLELIDSRPTLVDGTKPLSPE 329
+T GT ++ + L RP L + Q+ A + ++DS+ G++ +
Sbjct: 279 LTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFSILDSKQETDSGSRTIE-R 337
Query: 330 ARLSLEFQRVSFGYVA-DRPVLREISLSVRAGETLAVVGAPGSGKSTLASLATRCYDVTQ 388
A+ +EF++V+F Y D P L+ I+LS+ G+T+A+VG GSGKST+ASL TR YD+ Q
Sbjct: 338 AKGDVEFRQVTFTYPGRDVPALQNINLSIPEGKTVALVGRSGSGKSTIASLMTRFYDIQQ 397
Query: 389 GAVRIGGQDVRELTLDSLRSAIGLVPEDAVLFSGTIGANIAYGRPD-ATPEQIATAARAA 447
G + I G D+RE TL SLR+ + LV ++ LF+ T+ NIAY R + + E I AA A
Sbjct: 398 GEILIDGHDLREYTLRSLRNQVALVSQNVHLFNDTVANNIAYARAEHYSREDIEKAAIMA 457
Query: 448 HIEEFVNTLPDGYQTAVGARGLTLSGGQRQRIALARALLHQPRLLIMDDPTSAVDAVIEC 507
H +F+ + +G T +G G+ LSGGQRQRIA+ARALL +LI+D+ TSA+D E
Sbjct: 458 HAMDFIKKMDNGLDTVIGENGVLLSGGQRQRIAIARALLRDCPILILDEATSALDTESEH 517
Query: 508 GIQEVLREAIADRTAVIFTRRRSMLTLADRVAVLDSGRLLDVGT 551
IQ L E +RT+++ R S + AD + V++ G +++ G+
Sbjct: 518 AIQAALDELQKNRTSLVIAHRLSTIEKADEIVVVEDGHIVERGS 561