Pairwise Alignments

Query, 1194 a.a., Probable transmembrane multidrug efflux pump from Mycobacterium tuberculosis H37Rv

Subject, 590 a.a., SmdA family multidrug ABC transporter permease/ATP-binding protein from Escherichia coli ECRC100

 Score =  274 bits (701), Expect = 1e-77
 Identities = 193/571 (33%), Positives = 294/571 (51%), Gaps = 22/571 (3%)

Query: 8   RLSGYVMRHRRDLLLGFGAALAGTVIAVLVPLVTKRVID---DAIAADH---RPLAPWAV 61
           +LS Y  R  R  L     A+A  VI  ++ LV  +V+    D +   H     +  W  
Sbjct: 6   QLSWYFRREWRRYL----GAVALLVIIAMLQLVPPKVVGIVVDGVTEQHFTTGQILMWIA 61

Query: 62  VLVAAAGATYLLMYVRRYYGGRIAHLVQHDLRMDAFQALLRWDGRQQDRWSSGQLIVRTT 121
            +V  A   YLL YV R      ++ +  +LR D ++ L R       R  +G L+ R T
Sbjct: 62  TMVLIAVVVYLLRYVWRVLLFGASYQLAVELREDYYRQLSRQHPEFYLRHRTGDLMARAT 121

Query: 122 NDLQLVQALLFDVPNVLRHVLTLLLGVAVM----TWLSVPLALLAVLLVPVIGLIAHRSR 177
           ND+  V     +   VL  V +L++G AV+    T +S  L L A+L +PV+ ++  R+ 
Sbjct: 122 NDVDRVVFAAGE--GVLTLVDSLVMGCAVLIMMSTQISWQLTLFALLPMPVMAIMIKRNG 179

Query: 178 RLLAAATHCAQEHKAAVTGVVDAAVCGIRVVKAFGQEERETVKLVTASRALYAAQLRVAR 237
             L      AQ   +++      ++  IR++KAFG E+R++      +       +RVAR
Sbjct: 180 DALHERFKLAQAAFSSLNDRTQESLTSIRMIKAFGLEDRQSALFAADAEDTGKKNMRVAR 239

Query: 238 LNAHFGPLLQTLPALGQMAVFALGG--WMAAQGSITVGTFVAFWACLTLLARPACDLAGM 295
           ++A F P +    A+G   + A+GG  WM  QGS+T+G   +F   L L+  P   LA M
Sbjct: 240 IDARFDPTIYI--AIGMANLLAIGGGSWMVVQGSLTLGQLTSFMMYLGLMIWPMLALAWM 297

Query: 296 LTIAQQARAGAVRVLELIDSRPTLVDGTKPLSPEARLSLEFQRVSFGYV-ADRPVLREIS 354
             I ++  A   R+  ++   P + DG++P+ PE R  L+     F Y   D P L  ++
Sbjct: 298 FNIVERGSAAYSRIRAMLAEAPVVNDGSEPV-PEGRGELDVNIHQFTYPQTDHPALENVN 356

Query: 355 LSVRAGETLAVVGAPGSGKSTLASLATRCYDVTQGAVRIGGQDVRELTLDSLRSAIGLVP 414
            +++ G+ L + G  GSGKSTL SL  R +DV++G +R     + +L LDS RS + +V 
Sbjct: 357 FALKPGQMLGICGPTGSGKSTLLSLIQRHFDVSEGDIRFHDIPLTKLQLDSWRSRLAVVS 416

Query: 415 EDAVLFSGTIGANIAYGRPDATPEQIATAARAAHIEEFVNTLPDGYQTAVGARGLTLSGG 474
           +   LFS T+  NIA G P+AT ++I   AR A + + +  LP GY T VG RG+ LSGG
Sbjct: 417 QTPFLFSDTVANNIALGCPNATQQEIEHVARLASVHDDILRLPQGYDTEVGERGVMLSGG 476

Query: 475 QRQRIALARALLHQPRLLIMDDPTSAVDAVIECGIQEVLREAIADRTAVIFTRRRSMLTL 534
           Q+QRI++ARALL    +LI+DD  SAVD   E  I   LR+    RT +I   R S LT 
Sbjct: 477 QKQRISIARALLVNAEILILDDALSAVDGRTEHQILHNLRQWGQGRTVIISAHRLSALTE 536

Query: 535 ADRVAVLDSGRLLDVGTPDEVWERCPRYREL 565
           A  + V+  G +   G  D + ++   YR++
Sbjct: 537 ASEIIVMQHGHIAQRGNHDVLAQQSGWYRDM 567



 Score =  233 bits (595), Expect = 3e-65
 Identities = 159/563 (28%), Positives = 277/563 (49%), Gaps = 10/563 (1%)

Query: 617  RRLLREFRGPLALSLLLVAVQTCAGLLPPLLIRHGIDVGIRRHVLSA---LWWAALAGTA 673
            RR  R + G +AL +++  +Q    L+PP ++   +D    +H  +    +W A +   A
Sbjct: 12   RREWRRYLGAVALLVIIAMLQ----LVPPKVVGIVVDGVTEQHFTTGQILMWIATMVLIA 67

Query: 674  TVVIRWVVQWGSAMVAGYTGEQVLFRLRSVVFAHAQRLGLDAFEDDGDAQIVTAVTADVE 733
             VV      W   +       Q+   LR   +    R   + +       ++   T DV+
Sbjct: 68   VVVYLLRYVWRVLLFGA--SYQLAVELREDYYRQLSRQHPEFYLRHRTGDLMARATNDVD 125

Query: 734  AIVAFLRTGLVVAVISVVTLVGILVALLA-IRARLVLLIFTTMPVLALATWQFRRASNWT 792
             +V     G++  V S+V    +L+ +   I  +L L     MPV+A+   +   A +  
Sbjct: 126  RVVFAAGEGVLTLVDSLVMGCAVLIMMSTQISWQLTLFALLPMPVMAIMIKRNGDALHER 185

Query: 793  YRRARHRLGTVTATLREYAAGLRIAQAFRAEYRGLQSYFAHSDDYRRLGVRGQRLLALYY 852
            ++ A+    ++    +E    +R+ +AF  E R    + A ++D  +  +R  R+ A + 
Sbjct: 186  FKLAQAAFSSLNDRTQESLTSIRMIKAFGLEDRQSALFAADAEDTGKKNMRVARIDARFD 245

Query: 853  PFVALLCSLATTLVLLDGAREVRAGVISVGALVTYLLYIELLYTPIGELAQMFDDYQRAA 912
            P + +   +A  L +  G+  V  G +++G L ++++Y+ L+  P+  LA MF+  +R +
Sbjct: 246  PTIYIAIGMANLLAIGGGSWMVVQGSLTLGQLTSFMMYLGLMIWPMLALAWMFNIVERGS 305

Query: 913  VAAGRIRSLLSTRTPSSPAARPVGTLRGEVVFDAVHYSYRTREVPALAGINLRIPAGQTV 972
             A  RIR++L+     +  + PV   RGE+  +   ++Y   + PAL  +N  +  GQ +
Sbjct: 306  AAYSRIRAMLAEAPVVNDGSEPVPEGRGELDVNIHQFTYPQTDHPALENVNFALKPGQML 365

Query: 973  VFVGSTGSGKSTLIKLVARFYDPTHGTVRVDGCDLREFDVDGYRNRLGIVTQEQYVFAGT 1032
               G TGSGKSTL+ L+ R +D + G +R     L +  +D +R+RL +V+Q  ++F+ T
Sbjct: 366  GICGPTGSGKSTLLSLIQRHFDVSEGDIRFHDIPLTKLQLDSWRSRLAVVSQTPFLFSDT 425

Query: 1033 VRDAIAYGRPDATDAQVERAAREVGAHPMITALDNGYLHQVTAGGRNLSAGQLQLLALAR 1092
            V + IA G P+AT  ++E  AR    H  I  L  GY  +V   G  LS GQ Q +++AR
Sbjct: 426  VANNIALGCPNATQQEIEHVARLASVHDDILRLPQGYDTEVGERGVMLSGGQKQRISIAR 485

Query: 1093 ARLVDPDILLLDEATVALDPATEAVVQRATLTLAARRTTLIVAHGLAIAEHADRIVVLEH 1152
            A LV+ +IL+LD+A  A+D  TE  +          RT +I AH L+    A  I+V++H
Sbjct: 486  ALLVNAEILILDDALSAVDGRTEHQILHNLRQWGQGRTVIISAHRLSALTEASEIIVMQH 545

Query: 1153 GTVVEDGAHTELLAAGGHYSRLW 1175
            G + + G H  L    G Y  ++
Sbjct: 546  GHIAQRGNHDVLAQQSGWYRDMY 568