Pairwise Alignments

Query, 823 a.a., DNA topoisomerase I from Methanococcus maripaludis S2

Subject, 907 a.a., DNA topoisomerase 1 from Xanthobacter sp. DMC5

 Score =  187 bits (474), Expect = 3e-51
 Identities = 188/689 (27%), Positives = 295/689 (42%), Gaps = 105/689 (15%)

Query: 4   LIICEKPNVAKKIAEALGKPKKKSHNSVPYYELERNGESIVVASAVGHLYTLQEKTKTKF 63
           ++I E P  AK I + LG          P YE         V ++ GH+  L  K  +  
Sbjct: 15  VVIVESPAKAKTINKYLG----------PGYE---------VIASYGHVRDLPSKDGSVD 55

Query: 64  GDYPVYDINWVPASTLDEKKYIQKYIDALKKVSKDANKFYVATDWDIEGELIGYHALNFS 123
            D   + + W      D     QK ++ +    K A+   +ATD D EGE I +H L   
Sbjct: 56  PDAD-FRMLW------DVDPKAQKRLNEIAAAVKGADGLILATDPDREGEAISWHVLEVL 108

Query: 124 CGQK-----NAHRLRFSSLTKKEILKAYENPNEIDFGLVDAGDSRHKIDWYFGINVSRAL 178
             +K        R+ F+++TK+ +L+A ++P  ID  LVDA  +R  +D+  G  +S  L
Sbjct: 109 RQKKALKSQKVERVVFNAITKQAVLEAMKSPRAIDSALVDAYLARRALDYLVGFTLSPVL 168

Query: 179 MQAVSSVKRWKTLSTGRVQGPALAFLVDKELEIRNFVPTPYWVLEALLDN---------- 228
            + +   +     S GRVQ  AL  + D+E EI  FV   YW + A L            
Sbjct: 169 WRKLPGAR-----SAGRVQSVALRLVCDREREIETFVRKEYWSILAKLATPRNEEFEARL 223

Query: 229 ---DLIAVHELEKFWDEEQANKAYEKVKGQKQATVSDVKKSMKTIPPNPPFDLGALQREA 285
              D   +  L     EE   +A+ +        V  V+       P PPF    LQ+EA
Sbjct: 224 SGADGKKITRLSVGTAEEA--RAFREALDSAAFRVRSVEAKPMKRHPQPPFTTSTLQQEA 281

Query: 286 HNMFRFSPKKTQEVAQKLYEK--------GYCSYPRTSSQKLPDDKAYMDEVLKNLSKNK 337
                 +P +T ++AQ+LYE         G  +Y RT    +  +              +
Sbjct: 282 SRKLGLAPARTMQIAQRLYEGVDVGGETVGLITYMRTDGVDMAPEAVAATRDAIGKQFGQ 341

Query: 338 NYKPYIETILNENRKPISGKNDDPAHPAVHAVDVPKEK------LPDDELKLYELIARRT 391
            Y P +       +     KN   AH A+   D  +        L  ++ KLYELI  RT
Sbjct: 342 KYLPGVP-----RKYTTKAKNAQEAHEAIRPTDPSRHPRDVARYLDGEQAKLYELIWIRT 396

Query: 392 IALYWDNAKREYSKINLDING--ETFKLSGSRTVE--EGWHEIYYYTKFDEVE------L 441
           +A   ++A+ E +  +++      T  L+ + TV   +G+  +Y   K DE +      L
Sbjct: 397 VASQMESAELERTTADIEAKAGARTLDLTATGTVVKFDGFLTLYREGKDDEDDDEEGRRL 456

Query: 442 PELKKNDVINVNNINFEAKETKPPKRYTMASIIKELEKRKLGTKATRADILEKLTKRGYV 501
           P +  N+ +   +I+     T+PP RY+ AS++K +E+  +G  +T A +L  L  R YV
Sbjct: 457 PAMSANEALAKRDISTTQHFTEPPPRYSEASLVKRMEELGIGRPSTYAAVLAVLRDREYV 516

Query: 502 -IEDGSLTVTDLGIGVTETLRKYCPEIVEETLTRDLEDKLELIQDKKIKKEEV------- 553
            ++   L   D G  VT  L  +    VE   T DLE+KL+ +   ++  +EV       
Sbjct: 517 KLDKKKLVPEDKGRLVTAFLESFFKRYVEYDFTADLEEKLDEVSAAELDWKEVLRAFWQD 576

Query: 554 ----IQETKD-KLTKILGEFRLKEKEIGTELVDKLDSTNRSLQIIGKC-KCGGDMIIIRT 607
               I+ TKD +++++L    L E         + D T+  L     C  CG   + ++ 
Sbjct: 577 FHAAIEATKDLRVSQVLD--ALDEMLTAHIFPPREDGTDPRL-----CPTCGTGRLSLKM 629

Query: 608 KGKKRFVGCSNYPDCEVTFPL----PQKG 632
                F+GCSNYP+C  T PL    PQ+G
Sbjct: 630 GKFGAFIGCSNYPECRHTRPLTGDNPQEG 658



 Score = 62.8 bits (151), Expect = 9e-14
 Identities = 30/102 (29%), Positives = 53/102 (51%), Gaps = 5/102 (4%)

Query: 680 EEKICPKCGN-KLLIKKGPYGVFRGCENYPKCKYTEKLNGESNEK----EIVGKCPKCGS 734
           + ++CP CG  +L +K G +G F GC NYP+C++T  L G++ ++     ++G  P  G 
Sbjct: 613 DPRLCPTCGTGRLSLKMGKFGAFIGCSNYPECRHTRPLTGDNPQEGDGTRVLGLDPDSGE 672

Query: 735 DLYKRKGRFGEFIGCSNYPKCRHTEKIDKKKEDTPGETKAET 776
           ++  R GRFG ++      +    ++    K   P +   ET
Sbjct: 673 EVTIRSGRFGTYLQLGEGKEGEKPKRSSLPKGLAPADVDLET 714



 Score = 55.1 bits (131), Expect = 2e-11
 Identities = 40/110 (36%), Positives = 49/110 (44%), Gaps = 15/110 (13%)

Query: 725 IVGKCPKCGSDLYKRKGRFGEFIG----CSNYPKCRHTEK---------IDKKKEDTPGE 771
           +VG  P  G  +  R GRFG ++      +  PK    E          ID K   +P +
Sbjct: 792 VVGDHPTLGGPITVRPGRFGPYVNHGKVNATLPKSTDPEALTLEQAVQLIDAKAASSPAK 851

Query: 772 TKAETKKEAKPKTTKKAAPKKTATKTTKTTAKKTATKKTTTKKATAKKTA 821
                +K A     +KAAPKK A K  K  AKKTATK    KK  AKK A
Sbjct: 852 PARGARKAAAGDDGEKAAPKKAAAK--KPAAKKTATKAAAPKKPAAKKAA 899