Pairwise Alignments

Query, 823 a.a., DNA topoisomerase I from Methanococcus maripaludis S2

Subject, 987 a.a., DNA topoisomerase III, Burkholderia type (EC 5.99.1.2) from Variovorax sp. SCN45

 Score =  169 bits (429), Expect = 5e-46
 Identities = 166/631 (26%), Positives = 280/631 (44%), Gaps = 88/631 (13%)

Query: 4   LIICEKPNVAKKIAEALGKPKKKSHNSVPYYELERNGESIVVASAVGHLYTLQ------- 56
           L+I EKP+VA+ I  AL     K      ++E     +S VV SAVGHL  +Q       
Sbjct: 5   LVIAEKPSVAQDIVRALTPVAGKFDKHDEHFE----NDSYVVTSAVGHLVEIQAPEEFDV 60

Query: 57  EKTKTKFGDYPVYDINWVPASTLDEKKYIQKYIDALKKVSKDANKFYVATDWDIEGELIG 116
           ++ K  F + PV   ++        K  +   +   K+  KD  +   A D   EGELI 
Sbjct: 61  KRGKWSFANLPVIPPHFDLKPVDKTKTRLNAVVKQAKR--KDVTQLINACDAGREGELIF 118

Query: 117 YHALNFSCGQ----KNAHRLRFSSLTKKEILKAYE--NPNEIDFGLVDAGDSRHKIDWYF 170
                ++ G+    K   RL   S+T + I   ++     +   GL DA  SR + DW  
Sbjct: 119 RLIEQYAGGKSGLNKPVKRLWLQSMTPQAIRDGFDALRTEKQMQGLADAARSRSEADWLV 178

Query: 171 GINVSRALMQAVSSVKRWKTLSTGRVQGPALAFLVDKELEIRNFVPTPYWVLEA------ 224
           GIN +RA+    S    +   + GRVQ P L+ +V++E +IR FV   YW +        
Sbjct: 179 GINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSVVVEREEQIRKFVSRDYWEIHGTFAAEA 238

Query: 225 -------------------LLDNDLIAVHELEKFWDEEQANKAYEKVKGQKQATVSDVKK 265
                              L + +       ++ W+E++A    +  +G K ATV++  K
Sbjct: 239 GEYPGKWFNPDWKKANAPLLANGEPDPEQRADRVWNEQEARAIADAARG-KPATVTEESK 297

Query: 266 SMKTIPPNPPFDLGALQREAHNMFRFSPKKTQEVAQKLYEKGYC-SYPRTSSQKLPDDKA 324
                 P   FDL +LQREA+  F FS K T  +AQ LYE+    +YPRT S+ LP+D  
Sbjct: 298 PTTQASPML-FDLTSLQREANGRFGFSAKTTLALAQSLYERHKALTYPRTDSRALPED-- 354

Query: 325 YMDEVLKNL-----SKNKNYKPYIETILNENRKPISGKNDDPAHPAVHAVDVPKEKLP-- 377
           Y+  V   +     S  K+  P+ +  ++ N    + +  D A  + H   +P  + P  
Sbjct: 355 YLPVVKDTMGMLANSGMKHLAPFAKQAVDGNYVRPNKRIFDNAKVSDHFAIIPTLQAPSG 414

Query: 378 --DDELKLYELIARRTIALYWDNAKRE----YSKINLDINGETFKLSGSRTVEEGWHEIY 431
             + E KLY+ + RR +++++ +A+ +     S +        F+  G   V+ GW  IY
Sbjct: 415 LSEAEQKLYDFVVRRFLSVFFPSAEYQVTTRISTVEQGGKKYPFRTDGKVLVKPGWLAIY 474

Query: 432 YYTKFDEVE--------LPELKKNDVINVNNINFEAKETKPPKRYTMASII--------- 474
                D+ +        L  +K  +++   + + +  +T+PP RY+ A+++         
Sbjct: 475 GKEAQDDEKEDDKDGKRLVPVKPGEIVKTESADTKGLKTRPPARYSEATLLGAMEGAGKT 534

Query: 475 -------KELEKRKLGTKATRADILEKLTKRGYVIEDG-SLTVTDLGIGVTETLRKY-CP 525
                  + ++++ LGT ATRA  +E L    Y++ +G  L  T     +   LR     
Sbjct: 535 IDDDELREAMQEKGLGTPATRAATIEGLITEKYMLREGRELIPTAKAFQLMTLLRGLGVE 594

Query: 526 EIVEETLTRDLEDKLELIQDKKIKKEEVIQE 556
           E+ +  LT + E KL  ++   + ++  ++E
Sbjct: 595 ELSKAELTGEWEYKLAQMEKGALSRDAFMRE 625