Pairwise Alignments

Query, 823 a.a., DNA topoisomerase I from Methanococcus maripaludis S2

Subject, 860 a.a., DNA topoisomerase I (EC 5.99.1.2) from Sphingobium sp. HT1-2

 Score =  215 bits (548), Expect = 7e-60
 Identities = 240/904 (26%), Positives = 378/904 (41%), Gaps = 135/904 (14%)

Query: 4   LIICEKPNVAKKIAEALGKPKKKSHNSVPYYELERNGESIVVASAVGHLYTLQEKTKTKF 63
           L+I E P  AK I + LG                  G+  V+AS  GH+  L  K  +  
Sbjct: 3   LVIVESPAKAKTIEKYLG------------------GDFHVLAS-YGHIRDLPPKDGSVD 43

Query: 64  GDYPVYDINWVPASTLDEKKYIQKYIDALKKVSKDANKFYVATDWDIEGELIGYHALNFS 123
            D   + ++W      D+ K ++   D  KK    A +  +ATD D EGE I +H     
Sbjct: 44  PDNG-FAMSWENYG--DKGKQLKAIADEAKK----ATRLILATDPDREGEAISWHVQEVL 96

Query: 124 CGQK----NAHRLRFSSLTKKEILKAYENPNEIDFGLVDAGDSRHKIDWYFGINVSRALM 179
             +K       R+ F+++TK  +L A   P  +D  L+DA  +R  +D+  G  +S  L 
Sbjct: 97  RAKKALPQTVDRVTFNAITKAAVLDAMAKPRALDEDLIDAYRARRALDYLVGFTLSPVLW 156

Query: 180 QAVSSVKRWKTLSTGRVQGPALAFLVDKELEIRNFVPTPYWVLEALLDNDLIAVHELEKF 239
           + +   K     S GRVQ  AL  +V++E EI +FVP  YW + A ++            
Sbjct: 157 RKLPGAK-----SAGRVQSVALRLVVEREREIESFVPQEYWSISAEMEQGGQGFTARLVR 211

Query: 240 WDEEQANKAYEKVKGQKQATVSDVKKSMKTIP----------PNPPFDLGALQREAHNMF 289
           W  E+ ++     +G   A  +DV+    T+           P PPF    LQ+EA    
Sbjct: 212 WKGEKIDRLTIGKEGDAMAAKADVEAGRFTVDKVETKPLTRNPPPPFTTSTLQQEAARKL 271

Query: 290 RFSPKKTQEVAQKLYEKGYCSYPRTSSQKLPDDKAYMDEVLKNLSKNKNYKPYIETILNE 349
            FS   T  +AQ+LYE G  +Y RT       D   MD    + ++    + Y    L E
Sbjct: 272 GFSASHTMRIAQQLYEDGAITYMRT-------DGVQMDGSAISAARKAIAERYDGGYLPE 324

Query: 350 NRKPIS--GKNDDPAHPAVHAVDVPKEKLPD-DELKLYELIARRTIALYWDNAKREYSKI 406
             +      KN   AH A+   +  ++K+   D  +LY+LI +R +A    +A+ E + I
Sbjct: 325 KPRQYQTKAKNAQEAHEAIRPTEFHRDKVGGGDHARLYDLIFKRALASQMASARLERTTI 384

Query: 407 NL-DINGE-TFKLSGSRTVEEGWHEIYYYTKFDEVE-----LPELKKNDVINVNNINFEA 459
           ++ D +G  T + +G   +  G+  +Y   + D  +     LP L + D      ++ E 
Sbjct: 385 DMVDGSGSHTLRATGQVVIFPGFLALYEEGRDDAEDDDSKLLPRLSEGDAPAKKKVSAEQ 444

Query: 460 KETKPPKRYTMASIIKELEKRKLGTKATRADILEKLTKRGYV-IEDGSLTVTDLGIGVTE 518
             T+PP RY+ AS++K+LE+  +G  +T A  L+ L  R YV +E       + G  VT 
Sbjct: 445 HFTQPPPRYSEASLVKKLEELGIGRPSTYASTLQVLKDRDYVRVEKNRFFAEESGRLVTA 504

Query: 519 TLRKYCPEIVEETLTRDLEDKLELIQDKKIKKEEVIQE-TKDKLTKILGEFRLKEKEIGT 577
            L ++    V    T  LED+L+ I   + + +EV++   KD   K       K  +I  
Sbjct: 505 FLERFFERYVSYDFTAGLEDELDEISGGRAQWQEVLEAFWKDFKPKTAEIMEQKPSDITA 564

Query: 578 EL---------VDKLDSTN-RSLQIIGKCKCGGDMIIIRTKGKKRFVGCSNYPDCEVTFP 627
           EL           K D +N R+  +     C    + +R      F+ CSNYP+C+ T  
Sbjct: 565 ELDKFLEPMLFPPKADGSNPRACPL-----CADGQLSLRGGRFGAFIACSNYPECKYTRK 619

Query: 628 LPQKGRIKVLNEVCEKC-QNPVIGLDRIKIC--VNPDCSTRISEEDK-----KEIEKAE- 678
             Q G     +   E   Q+P  G D +K      P       +E K     K++   E 
Sbjct: 620 FGQPGGSDGADTGPEILGQHPETGQDIVKKSGRFGPYIEMGEGKEAKRGSIPKDLPDGEM 679

Query: 679 ------------KEEKICPKCG----------NKLLIKKGPYG-------VFRGCENYPK 709
                       +E  + P+ G             L+  G YG       +F    N   
Sbjct: 680 TLDWAIKLLSLPREVGLHPETGLPIVANIGRFGPYLLHDGKYGRLSSTAEIFEVGMNMAV 739

Query: 710 CKYTEKLN-----GESNEK-EIVGKCPKCGSDLYKRKGRFGEFI--GCSNYPKCRHTEK- 760
            K  +  N     G S E  +++GK P+  +++    GR+G ++  G +N    +  E+ 
Sbjct: 740 AKLADAANKGGRGGSSREPLKVLGKHPRTEAEIKLMAGRYGPYVTDGTTNATLPKTIEQD 799

Query: 761 ---IDKKKEDTPGETKAETKKEAKPKTTKKAAPKKTATKTTKTTAKKTATKKTTTKKATA 817
              +++  +       A   K+ K    KKAA KK A K      K+T  KK   KK+ A
Sbjct: 800 ALTLEEAAQLIDARAAAAPAKKGKKAPAKKAAAKKPAAK------KETGEKKPAAKKSPA 853

Query: 818 KKTA 821
           KK A
Sbjct: 854 KKKA 857