Pairwise Alignments

Query, 823 a.a., DNA topoisomerase I from Methanococcus maripaludis S2

Subject, 641 a.a., DNA topoisomerase III from Serratia liquefaciens MT49

 Score =  159 bits (402), Expect = 5e-43
 Identities = 159/614 (25%), Positives = 280/614 (45%), Gaps = 65/614 (10%)

Query: 4   LIICEKPNVAKKIAEALGKPKKKSHNSVPYYELERNGESIVVASAVGHLYTLQEKTK--T 61
           L I EKP++A+ IA+ L KP ++    +        G + VV   VGHL    +     +
Sbjct: 3   LFIAEKPSLARAIADVLPKPHRRGDGFIAC------GNNDVVTWCVGHLLEQAQPDAYDS 56

Query: 62  KFGDYPVYDINWVPAS-TLDEKKYIQKYIDALKKVSKDANKFYVATDWDIEGELIGYHAL 120
           ++  + + D+  +P    L  +  + K ++A+KK+  +A++   A D D EG+L+    L
Sbjct: 57  RYARWSLADLPIIPEKWQLQPRPSVSKQLNAIKKLLHEADEVVHAGDPDREGQLLVDEVL 116

Query: 121 NFSC----GQKNAHRLRFSSLTKKEILKAYEN--PNEIDFGLVDAGDSRHKIDWYFGINV 174
           ++       + +  R   + L  + + +A E    N     L  +  +R + DW +GIN+
Sbjct: 117 DYLALTPEKRHSVRRCLINDLNPQAVERAIERLRDNRDFIPLCVSALARSRADWLYGINM 176

Query: 175 SRALMQAVSSVKRWKTLSTGRVQGPALAFLVDKELEIRNFVPTPYWVLEALL----DNDL 230
           +RA      +      LS GRVQ P L  +V ++ +I NFV   ++ ++A +    +   
Sbjct: 177 TRAYTILGRNAGYDGVLSVGRVQTPVLGLVVRRDEDIENFVSKDFFEVKAHIVTPKEERF 236

Query: 231 IAVHE----LEKFWDEEQ-------ANKAYEKVKGQKQATVS-DVKKSMKTIPPNPPFDL 278
           +A+ +     E + DEE        A    ++++GQ     S + K+   T P   PF L
Sbjct: 237 VALWQPSDSCEPYQDEEGRLLHRPLAEHVLKRIEGQPALVTSYNDKRESDTAPL--PFSL 294

Query: 279 GALQREAHNMFRFSPKKTQEVAQKLYEKG-YCSYPRTSSQKLPDDK-AYMDEVLKNLSKN 336
             LQ EA   F  S ++  +V Q+LYE     +YPR+  + LP++  A    VL  +S +
Sbjct: 295 STLQIEASKRFNLSAQQVLDVCQRLYETHKLITYPRSDCRYLPEEHFAGRHSVLNAISVH 354

Query: 337 KNYKPYIETILNENRKPI--SGKNDDPAHPAVHAVDVPKEKLPDDELKLYELIARRTIAL 394
           +    Y + +++ +R+      K  D  H  +      K  L  DEL +Y L+AR+ +  
Sbjct: 355 QP-DLYPQPVIDSDRRNRCWDDKKVDAHHAIIPTARASKVSLSQDELNVYGLVARQYLMQ 413

Query: 395 YWDNAKREYSKINLDINGETFKLSGSRTVEEGWHEIYYYTKFDE----VELPELKKNDVI 450
           +  +A      I LDI G  F        E GW  +    + DE      LP + K+D +
Sbjct: 414 FCPDAMFRKCVIELDIAGGKFIAKARFLAEAGWRTLLGSKERDEENEGAPLPVVAKDDEL 473

Query: 451 NVNNINFEAKETKPPKRYTMASII------------KELEK-----RKLGTKATRADILE 493
                    ++T+PP+ +T AS++            K L+K       LGT+ATRA I+E
Sbjct: 474 LCERGEVVERQTQPPRPFTDASLLSAMTGIARFVQDKALKKILRATDGLGTEATRAGIIE 533

Query: 494 KLTKRGYVIEDGS-LTVTDLGIGVTETLRKYCPEI-VEETLTRDLEDKLELIQDKKIKKE 551
            L KR ++ + G  +  ++ G  +  +L    P+I     +T + E  L  I +K  + +
Sbjct: 534 LLFKRAFLYKKGRYIHSSETGRALIHSL----PDIAARPDMTANWEATLTQISEKSCRYQ 589

Query: 552 EVIQETKDKLTKIL 565
           + +Q     L +++
Sbjct: 590 DFMQPLVGTLQELI 603