Pairwise Alignments

Query, 823 a.a., DNA topoisomerase I from Methanococcus maripaludis S2

Subject, 865 a.a., DNA topoisomerase I, omega subunit from Escherichia coli BL21

 Score =  240 bits (612), Expect = 3e-67
 Identities = 230/816 (28%), Positives = 352/816 (43%), Gaps = 120/816 (14%)

Query: 4   LIICEKPNVAKKIAEALGKPKKKSHNSVPYYELERNGESIVVASAVGHLYTLQ------- 56
           L+I E P  AK I + LG                      VV S+VGH+  L        
Sbjct: 5   LVIVESPAKAKTINKYLGS-------------------DYVVKSSVGHIRDLPTSGSAAK 45

Query: 57  ---EKTKTKFGDYPVYDI--------------NWVPASTLDEKKYIQKYIDALKKVSKDA 99
              + T TK    P  D               NW     +   K  +K +  LK++++ A
Sbjct: 46  KSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGK--EKVVSELKQLAEKA 103

Query: 100 NKFYVATDWDIEGELIGYHALNFSCGQKNAH-RLRFSSLTKKEILKAYENPNEIDFGLVD 158
           +  Y+ATD D EGE I +H      G    + R+ F+ +TK  I +A+  P E++   V+
Sbjct: 104 DHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVN 163

Query: 159 AGDSRHKIDWYFGINVSRALMQAVSSVKRWKTLSTGRVQGPALAFLVDKELEIRNFVPTP 218
           A  +R  +D   G  VS  L + ++     + LS GRVQ  A+  +V++E EI+ FVP  
Sbjct: 164 AQQARRFMDRVVGYMVSPLLWKKIA-----RGLSAGRVQSVAVRLVVEREREIKAFVPEE 218

Query: 219 YWVLEALLDNDLIAVHELEKFWDEEQANKAYEKV-KGQKQATVSDVKKSMKTI------- 270
           +W ++A           L+      Q +K +  V K Q QA VS ++K+  ++       
Sbjct: 219 FWEVDASTTTPSGEALALQV---THQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKP 275

Query: 271 ---PPNPPFDLGALQREAHNMFRFSPKKTQEVAQKLYEKGYCSYPRTSSQKLPDDKAYMD 327
               P  PF    LQ+ A     F  KKT  +AQ+LYE GY +Y RT S  L  D   M 
Sbjct: 276 TTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMV 335

Query: 328 EVLKNLSKNKNYKPYIETILNENRKPISGKNDDPAHPAVHA--VDVPKEKLPD---DELK 382
               + +  K Y P          +  S +N   AH A+    V+V  E L D   D  K
Sbjct: 336 RGYISDNFGKKYLP------ESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQK 389

Query: 383 LYELIARRTIALYWDNAKREYSKINLDINGETFKLSGSRTVEEGWHEIY-YYTKFDEVE- 440
           LY+LI R+ +A     AK + + + +       K  G     +GW ++     K DE   
Sbjct: 390 LYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRI 449

Query: 441 LPELKKNDVINVNNINFEAKETKPPKRYTMASIIKELEKRKLGTKATRADILEKLTKRGY 500
           LP + K D + +  +      TKPP R++ AS++KELEKR +G  +T A I+  +  RGY
Sbjct: 450 LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGY 509

Query: 501 V-IEDGSLTVTDLGIGVTETLRKYCPEIVEETLTRDLEDKLELIQDKKIKKEEVIQETKD 559
           V +E+       +G  VT+ L +   E++    T  +E+ L+ + + + + + V+     
Sbjct: 510 VRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFS 569

Query: 560 KLTKILGEFRLKEKEIGTELVDKLDSTNRSLQIIGKCKCGGDMIIIRTKGKKRFVGCSNY 619
             T+ L +     +E G          N+ +     C   G  + IRT     F+GCS Y
Sbjct: 570 DFTQQLDKAEKDPEEGGMR-------PNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGY 622

Query: 620 PDCEVTFPLPQKGRIKVLNEVCEKCQNPVIGLDRIKICVNPDCSTRISEEDKKEIEKAEK 679
                   LP K R       C+   N V   + + +    D  T            A +
Sbjct: 623 -------ALPPKER-------CKTTINLVPENEVLNVLEGEDAET-----------NALR 657

Query: 680 EEKICPKCGNKL---LIKKGPYGVFRGCENYPKCKYTEKLNGESNEKEIVG---KCPKCG 733
            ++ CPKCG  +   LI   P      C N P C   E   GE   K   G   +C KCG
Sbjct: 658 AKRRCPKCGTAMDSYLI--DPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCG 715

Query: 734 SDLYKRKGRFGEFIGCSNYPKCRHTEKIDKKKEDTP 769
           S+++ + GRFG+++ C+N  +C++T KI +  E  P
Sbjct: 716 SEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAP 750