Pairwise Alignments

Query, 590 a.a., putative multidrug resistance ABC transporter ATP-binding/permease protein YheI from Escherichia coli HS(pFamp)R (ATCC 700891)

Subject, 1194 a.a., Probable transmembrane multidrug efflux pump from Mycobacterium tuberculosis H37Rv

 Score =  274 bits (701), Expect = 1e-77
 Identities = 193/571 (33%), Positives = 294/571 (51%), Gaps = 22/571 (3%)

Query: 6   QLSWYFRREWRRYL----GAVALLVIIAMLQLVPPKVVGIVVDGVTEQHFTTGQILMWIA 61
           +LS Y  R  R  L     A+A  VI  ++ LV  +V+    D +   H     +  W  
Sbjct: 8   RLSGYVMRHRRDLLLGFGAALAGTVIAVLVPLVTKRVID---DAIAADH---RPLAPWAV 61

Query: 62  TMVLIAVVVYLLRYVWRVLLFGASYQLAVELREDYYRQLSRQHPEFYLRHRTGDLMARAT 121
            +V  A   YLL YV R      ++ +  +LR D ++ L R       R  +G L+ R T
Sbjct: 62  VLVAAAGATYLLMYVRRYYGGRIAHLVQHDLRMDAFQALLRWDGRQQDRWSSGQLIVRTT 121

Query: 122 NDVDRVVFAAGE--GVLTLVDSLVMGCAVLIMMSTQISWQLTLFALLPMPVMAIMIKRNG 179
           ND+  V     +   VL  V +L++G AV+    T +S  L L A+L +PV+ ++  R+ 
Sbjct: 122 NDLQLVQALLFDVPNVLRHVLTLLLGVAVM----TWLSVPLALLAVLLVPVIGLIAHRSR 177

Query: 180 DALHERFKLAQAAFSSLNDRTQESLTSIRMIKAFGLEDRQSALFAADAEDTGKKNMRVAR 239
             L      AQ   +++      ++  IR++KAFG E+R++      +       +RVAR
Sbjct: 178 RLLAAATHCAQEHKAAVTGVVDAAVCGIRVVKAFGQEERETVKLVTASRALYAAQLRVAR 237

Query: 240 IDARFDPTIYI--AIGMANLLAIGGGSWMVVQGSLTLGQLTSFMMYLGLMIWPMLALAWM 297
           ++A F P +    A+G   + A+GG  WM  QGS+T+G   +F   L L+  P   LA M
Sbjct: 238 LNAHFGPLLQTLPALGQMAVFALGG--WMAAQGSITVGTFVAFWACLTLLARPACDLAGM 295

Query: 298 FNIVERGSAAYSRIRAMLAEAPVVNDGSEPV-PEGRGELDVNIHQFTYPQTDHPALENVN 356
             I ++  A   R+  ++   P + DG++P+ PE R  L+     F Y   D P L  ++
Sbjct: 296 LTIAQQARAGAVRVLELIDSRPTLVDGTKPLSPEARLSLEFQRVSFGYV-ADRPVLREIS 354

Query: 357 FALKPGQMLGICGPTGSGKSTLLSLIQRHFDVSEGDIRFHDIPLTKLQLDSWRSRLAVVS 416
            +++ G+ L + G  GSGKSTL SL  R +DV++G +R     + +L LDS RS + +V 
Sbjct: 355 LSVRAGETLAVVGAPGSGKSTLASLATRCYDVTQGAVRIGGQDVRELTLDSLRSAIGLVP 414

Query: 417 QTPFLFSDTVANNIALGCPNATQQEIEHVARLASVHDDILRLPQGYDTEVGERGVMLSGG 476
           +   LFS T+  NIA G P+AT ++I   AR A + + +  LP GY T VG RG+ LSGG
Sbjct: 415 EDAVLFSGTIGANIAYGRPDATPEQIATAARAAHIEEFVNTLPDGYQTAVGARGLTLSGG 474

Query: 477 QKQRISIARALLVNAEILILDDALSAVDGRTEHQILHNLRQWGQGRTVIISAHRLSALTE 536
           Q+QRI++ARALL    +LI+DD  SAVD   E  I   LR+    RT +I   R S LT 
Sbjct: 475 QRQRIALARALLHQPRLLIMDDPTSAVDAVIECGIQEVLREAIADRTAVIFTRRRSMLTL 534

Query: 537 ASEIIVMQHGHIAQRGNHDVLAQQSGWYRDM 567
           A  + V+  G +   G  D + ++   YR++
Sbjct: 535 ADRVAVLDSGRLLDVGTPDEVWERCPRYREL 565



 Score =  233 bits (595), Expect = 3e-65
 Identities = 159/563 (28%), Positives = 277/563 (49%), Gaps = 10/563 (1%)

Query: 12   RREWRRYLGAVALLVIIAMLQ----LVPPKVVGIVVDGVTEQHFTTGQILMWIATMVLIA 67
            RR  R + G +AL +++  +Q    L+PP ++   +D    +H  +    +W A +   A
Sbjct: 617  RRLLREFRGPLALSLLLVAVQTCAGLLPPLLIRHGIDVGIRRHVLSA---LWWAALAGTA 673

Query: 68   VVVYLLRYVWRVLLFGA--SYQLAVELREDYYRQLSRQHPEFYLRHRTGDLMARATNDVD 125
             VV      W   +       Q+   LR   +    R   + +       ++   T DV+
Sbjct: 674  TVVIRWVVQWGSAMVAGYTGEQVLFRLRSVVFAHAQRLGLDAFEDDGDAQIVTAVTADVE 733

Query: 126  RVVFAAGEGVLTLVDSLVMGCAVLIMMSTQISWQLTLFALLPMPVMAIMIKRNGDALHER 185
             +V     G++  V S+V    +L+ +   I  +L L     MPV+A+   +   A +  
Sbjct: 734  AIVAFLRTGLVVAVISVVTLVGILVALLA-IRARLVLLIFTTMPVLALATWQFRRASNWT 792

Query: 186  FKLAQAAFSSLNDRTQESLTSIRMIKAFGLEDRQSALFAADAEDTGKKNMRVARIDARFD 245
            ++ A+    ++    +E    +R+ +AF  E R    + A ++D  +  +R  R+ A + 
Sbjct: 793  YRRARHRLGTVTATLREYAAGLRIAQAFRAEYRGLQSYFAHSDDYRRLGVRGQRLLALYY 852

Query: 246  PTIYIAIGMANLLAIGGGSWMVVQGSLTLGQLTSFMMYLGLMIWPMLALAWMFNIVERGS 305
            P + +   +A  L +  G+  V  G +++G L ++++Y+ L+  P+  LA MF+  +R +
Sbjct: 853  PFVALLCSLATTLVLLDGAREVRAGVISVGALVTYLLYIELLYTPIGELAQMFDDYQRAA 912

Query: 306  AAYSRIRAMLAEAPVVNDGSEPVPEGRGELDVNIHQFTYPQTDHPALENVNFALKPGQML 365
             A  RIR++L+     +  + PV   RGE+  +   ++Y   + PAL  +N  +  GQ +
Sbjct: 913  VAAGRIRSLLSTRTPSSPAARPVGTLRGEVVFDAVHYSYRTREVPALAGINLRIPAGQTV 972

Query: 366  GICGPTGSGKSTLLSLIQRHFDVSEGDIRFHDIPLTKLQLDSWRSRLAVVSQTPFLFSDT 425
               G TGSGKSTL+ L+ R +D + G +R     L +  +D +R+RL +V+Q  ++F+ T
Sbjct: 973  VFVGSTGSGKSTLIKLVARFYDPTHGTVRVDGCDLREFDVDGYRNRLGIVTQEQYVFAGT 1032

Query: 426  VANNIALGCPNATQQEIEHVARLASVHDDILRLPQGYDTEVGERGVMLSGGQKQRISIAR 485
            V + IA G P+AT  ++E  AR    H  I  L  GY  +V   G  LS GQ Q +++AR
Sbjct: 1033 VRDAIAYGRPDATDAQVERAAREVGAHPMITALDNGYLHQVTAGGRNLSAGQLQLLALAR 1092

Query: 486  ALLVNAEILILDDALSAVDGRTEHQILHNLRQWGQGRTVIISAHRLSALTEASEIIVMQH 545
            A LV+ +IL+LD+A  A+D  TE  +          RT +I AH L+    A  I+V++H
Sbjct: 1093 ARLVDPDILLLDEATVALDPATEAVVQRATLTLAARRTTLIVAHGLAIAEHADRIVVLEH 1152

Query: 546  GHIAQRGNHDVLAQQSGWYRDMY 568
            G + + G H  L    G Y  ++
Sbjct: 1153 GTVVEDGAHTELLAAGGHYSRLW 1175