Pairwise Alignments

Query, 860 a.a., Leucine--tRNA ligase from Escherichia coli HS(pFamp)R (ATCC 700891)

Subject, 969 a.a., Probable leucyl-tRNA synthetase LeuS (leucine--tRNA ligase) (LEURS) from Mycobacterium tuberculosis H37Rv

 Score =  533 bits (1372), Expect = e-155
 Identities = 345/933 (36%), Positives = 482/933 (51%), Gaps = 138/933 (14%)

Query: 33  EKYYCLSMLPYPSGR-LHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAV 91
           +K +   M PYPSG  LH+GH   Y   DV ARY RM+G+NVL  +G+DAFGLPAE  AV
Sbjct: 69  DKLFVQDMFPYPSGEGLHVGHPLGYIATDVYARYFRMVGRNVLHALGFDAFGLPAEQYAV 128

Query: 92  KNNTAPAPWTYDNIAYMKNQLKMLGFGYDWSRELATCTPEYYRWEQKFFTELYKKG---- 147
           +  T P   T  N+   + QL  LGFG+D  R  +T   ++YRW Q  F ++Y       
Sbjct: 129 QTGTHPRTRTEANVVNFRRQLGRLGFGHDSRRSFSTTDVDFYRWTQWIFLQIYNAWFDTT 188

Query: 148 -------------------------------------------LVYKKTSAVNWCPNDQT 164
                                                      LVY+  S VNWCP   T
Sbjct: 189 ANKARPISELVAEFESGARCLDGGRDWAKLTAGERADVIDEYRLVYRADSLVNWCPGLGT 248

Query: 165 VLANEQVI-DGCCWRCDTKVERKEIPQWFIKITAYADELLNDLDKLDHWPDTVKTMQRNW 223
           VLANE+V  DG   R +  V RK + QW ++ITAYAD LL+DLD LD WP+ VKTMQRNW
Sbjct: 249 VLANEEVTADGRSDRGNFPVFRKRLRQWMMRITAYADRLLDDLDVLD-WPEQVKTMQRNW 307

Query: 224 IGRSEGVEITFNV-----NNYDNTLTVYTTRPDTFMGCTYLAVAAGHPLAQKA------A 272
           IGRS G    F+      + ++  + V+TTRPDT  G TYL +A  H L  +       A
Sbjct: 308 IGRSTGAVALFSARAASDDGFEVDIEVFTTRPDTLFGATYLVLAPEHDLVDELVAASWPA 367

Query: 273 ENNP-----------ELAAFIDECRNTKVAEAEMA---TMEKKGVDTGFKAVHPLTGEEI 318
             NP            +AA+    R    A++++    + EK GV  G  A++P  GE +
Sbjct: 368 GVNPLWTYGGGTPGEAIAAY----RRAIAAKSDLERQESREKTGVFLGSYAINPANGEPV 423

Query: 319 PVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKPVILAADGSEPDLSQQALTEK 378
           P++ A++VL  YGTGA+MAVPGHDQRD++FA  +GL I  VI   +     +S+ A T  
Sbjct: 424 PIFIADYVLAGYGTGAIMAVPGHDQRDWDFARAFGLPIVEVIAGGN-----ISESAYTGD 478

Query: 379 GVLFNSGEFNGLDHEAAFNAIADKLTAMGVGERKVNYRLRDWGVSRQRYWGAPIPMVTLE 438
           G+L NS   NG+   AA  AI D+L + G G  ++ ++LRDW  +RQRYWG P P+V   
Sbjct: 479 GILVNSDYLNGMSVPAAKRAIVDRLESAGRGRARIEFKLRDWLFARQRYWGEPFPIVYDS 538

Query: 439 DGTVMPTPDDQLPVILPE-----DVVMDGITSPIKADPEWAKTTV---------NGM-PA 483
           DG      +  LPV LP+      V+ D   +  +  P  AK T          +G+ P 
Sbjct: 539 DGRPHALDEAALPVELPDVPDYSPVLFDPDDADSEPSPPLAKATEWVHVDLDLGDGLKPY 598

Query: 484 LRETDTFDTFMESSWYYARYTCPQYKEGMLDSKAANYWLP-------------VDIYIGG 530
            R+T+    +  SSWY  RYT P   E     +   YW+              VD+Y+GG
Sbjct: 599 SRDTNVMPQWAGSSWYELRYTDPHNSERFCAKENEAYWMGPRPAEHGPDDPGGVDLYVGG 658

Query: 531 IEHAIMHLLYFRFFHKLMRDAGMVNSDEPAKQLLCQGMVLADAFYYVGENGERNWVSPVD 590
            EHA++HLLY RF+HK++ D G V+S EP ++L+ QG + A A+        R    P +
Sbjct: 659 AEHAVLHLLYSRFWHKVLYDLGHVSSREPYRRLVNQGYIQAYAY-----TDARGSYVPAE 713

Query: 591 AIVERDEKGRIVKAKDAAGHELVYTGMSKMSKSKNNGIDPQVMVERYGADTVRLFMMFAS 650
            ++ER ++  +    D  G   V+    K+ KS  N + P  + + YGADT+R++ M   
Sbjct: 714 QVIERGDRF-VYPGPD--GEVEVFQEFGKIGKSLKNSVSPDEICDAYGADTLRVYEMSMG 770

Query: 651 PADMTLEWQESGVEGANRFLKRVWKLVY-EHTAKGDVAT---LNVDALTEDQKALRRDVH 706
           P + +  W    V GA RFL+RVW+LV  EHT +  VA    L++D L        R +H
Sbjct: 771 PLEASRPWATKDVVGAYRFLQRVWRLVVDEHTGETRVADGVELDIDTL--------RALH 822

Query: 707 KTIAKVTDDIGRRQTFNTAIAAIMELMNKLAKAPTDGEQDRALMQEALLAVVRMLNPFTP 766
           +TI  V++D    +  NTA A ++E  N L K   D     A+ + A+  +V+ML P  P
Sbjct: 823 RTIVGVSEDFAALRN-NTATAKLIEYTNHLTKKHRD-----AVPRAAVEPLVQMLAPLAP 876

Query: 767 HICFTLWQELKGEGDIDNAPWPVADEKAMVEDSTLVVVQVNGKVRAKITVPVDATEEQVR 826
           HI   LW  L     + + P+P AD   +V+++    VQVNGKVR ++ V  D  EE ++
Sbjct: 877 HIAEELWLRLGNTTSLAHGPFPKADAAYLVDETVEYPVQVNGKVRGRVVVAADTDEETLK 936

Query: 827 ERAGQEHLVAKYLDGVTVRKVIYVPGKLLNLVV 859
                +  V  +L G T RKVI V G+L+NLV+
Sbjct: 937 AAVLTDEKVQAFLAGATPRKVIVVAGRLVNLVI 969