Pairwise Alignments

Query, 760 a.a., DNA topoisomerase I (TIGR) from Desulfovibrio vulgaris Hildenborough JW710

Subject, 869 a.a., DNA topoisomerase I from Pseudomonas putida KT2440

 Score =  518 bits (1335), Expect = e-151
 Identities = 302/766 (39%), Positives = 425/766 (55%), Gaps = 84/766 (10%)

Query: 1   MGKDLIIVESPAKVKTIKKFLGGKYVVQASVGHVRDLPTN-------------------- 40
           MGK L+IVESPAK KTI K+LG +YVV++S+GH+RDLPT+                    
Sbjct: 1   MGKSLVIVESPAKAKTINKYLGNQYVVKSSIGHIRDLPTSGSASASKEPAAKRGKAAGEA 60

Query: 41  ---------------EIGVDEANNFAPQYRVIDGKQKVVDTLREAAAKADTVYLAPDPDR 85
                           +GVD  + +  +Y ++ GK+KV++ LR  A  ADT+YLA D DR
Sbjct: 61  PALSPKEKARRQLVARMGVDPDHGWKAKYEILPGKEKVIEELRRLAKDADTIYLATDLDR 120

Query: 86  EGEAIAWHVAALIEGKADNIKRIQFNEITARAVREALENPRDLNRALFDAQQARRVLDRL 145
           EGEAIAWH+   I G     KR+ FNEIT +A++EA   P +L+    +AQQARR LDR+
Sbjct: 121 EGEAIAWHLREAIGGDDTRYKRVVFNEITKKAIQEAFSQPGELDIDRVNAQQARRFLDRV 180

Query: 146 VGYKLSPLLWKKVKRGISAGRVQSVALRLIVDRESERRAFTPEEYWLFRAMF--AKNVPG 203
           VGY +SPLLW K+ RG+SAGRVQSVA++L+V+RE E RAF PEEYW   A    AKN   
Sbjct: 181 VGYMVSPLLWAKIARGLSAGRVQSVAVKLVVEREREIRAFIPEEYWEIHADLGTAKN--- 237

Query: 204 ATPTSPDPQYAPFKAELAKIDGKKAHVADADAANALEDAMRGKPFVITAVERKKRERQPQ 263
                     A  + E+A+  G+     +   A A  + ++   + +   E +    +P 
Sbjct: 238 ----------AKVRFEVAREKGEAFKPLNEAQAMAALEKLKASSYSVVKREDRPTSSKPS 287

Query: 264 PPFITSTLQQAANQRLGYSAKRTMNIAQRLYEGVELGEMGTVALITYMRTDSVRVSDEAR 323
            PFITSTLQQAA+ RLG+  K+TM +AQRLYE            ITYMRTDS  +S +A 
Sbjct: 288 APFITSTLQQAASNRLGFGVKKTMMMAQRLYE---------AGYITYMRTDSTNLSADAL 338

Query: 324 DAARAFVTETWGADFCPAKPRQFKTKGSAQDAHEAVRPVDVNVTPDSVKHLLPPDQFQLY 383
           D AR+++   +G  + P  P  + +K  AQ+AHEA+RP DVN  P  +   +  D  +LY
Sbjct: 339 DMARSYIEREFGKQYLPEAPLVYGSKEGAQEAHEAIRPSDVNTHPTKLSG-MERDAERLY 397

Query: 384 RLVWSRFVASQMAPARFDDTTVAIACGPAEWRAKGERMLFPGFLAAMPQ--KEEGDAELP 441
            L+W +F+A QM PA++  T+V +A G  E RAKG  + F G+   +PQ  K   D  LP
Sbjct: 398 ELIWRQFLACQMPPAQYLSTSVTVAAGDFELRAKGRILKFDGYTRVLPQQSKPGEDDVLP 457

Query: 442 PLQEGETLHPVSVEKEQKFTQPPARYTEASLVRELEERGIGRPSTYASIISTLIDRDYTR 501
            + +GE L  + ++  Q FT+PPAR+TEASLV+E+E+RGIGRPSTYA+IIST+ DR Y  
Sbjct: 458 EMVQGEALKLIQIDPSQHFTKPPARFTEASLVKEMEKRGIGRPSTYAAIISTIQDRGYVT 517

Query: 502 LEDKHFVPTDLGATVCDLLARHFTTLMDVGFTAQMEDSLDKVAEGGLDWVELLSRFSADF 561
           L ++ F    +G  V + L+  F+ LMD GFTA ME++LD VA+G  DW  +L  F  DF
Sbjct: 518 LHNRRFYSEKMGDIVTERLSESFSNLMDYGFTADMEENLDDVAQGERDWKNVLDEFYGDF 577

Query: 562 NPTLESAAKAMETVKGGLP--TDVTCPECGKPVVVKFGKAGPFLACTAY-----PDCKFT 614
           +  L++A  + + ++   P  T++ C ECG+P++++    G FL C+ Y       CK T
Sbjct: 578 SKKLQTAESSEDGMRANQPTMTNIPCKECGRPMMIRTASTGVFLGCSGYSLPPKERCKAT 637

Query: 615 SNFSRDEKGDIVIEQRAREE---LEAVGTCPECGKDLVVKKARTGSRFIACTGYPDC--- 668
            N    +  +I  +     E   L     CP C   +         +   C   PDC   
Sbjct: 638 VNLVPGD--EIAADDEGESESRVLLGKHRCPICATAMDAYLLDEKHKLHICGNNPDCVGY 695

Query: 669 -----RHTEPFSTGIACPREGCDGQLVEKSSKRGKIFYSCNRFPKC 709
                 +      G +   + C  ++  K+ + GK F   N  P C
Sbjct: 696 EIEEGNYRIKGYEGPSLECDKCGSEMQLKTGRFGKFFGCTN--PAC 739