Pairwise Alignments

Query, 693 a.a., Topoisomerase IA from Echinicola vietnamensis KMM 6221, DSM 17526

Subject, 876 a.a., DNA topoisomerase 1 from Vibrio cholerae E7946 ATCC 55056

 Score =  126 bits (316), Expect = 5e-33
 Identities = 142/567 (25%), Positives = 238/567 (41%), Gaps = 91/567 (16%)

Query: 87  GAIKQLKIIEQLFNRSDGIIVATDAGREGELIFRYIYEYLKCI-KPFQRLWISSLTEKAI 145
           G  K +  +++L   +D + +ATD  REGE I  ++ E +    K ++R+  + +T+ AI
Sbjct: 96  GKEKVVAELQKLAKDADSVYLATDLDREGEAIAWHLREIIGGDEKRYKRVVFNEITKNAI 155

Query: 146 KQGFDNLKDGKEFDGLYQAAQGRSRADWLVGINATQALSIAAGNGVYSLGRVQTPTLALI 205
           +Q F    +    DG+  A Q R   D +VG   +  L      G+ S GRVQ+  + L+
Sbjct: 156 QQAFKQPGE-LNMDGV-NAQQARRFMDRVVGFMVSPLLWKKVARGL-SAGRVQSVAVKLL 212

Query: 206 CRRYLENKNFSVQKYWQIQLSH-TKEFIEFKSLSKNKWDNQKLAKDTLKSIERNGNTAAV 264
             R  E K F  +++W I     T +  +F+ L   K     LA   +   E     AA+
Sbjct: 213 VEREREIKAFVPEEFWDINADTLTADKQDFRLLVAQK---DGLAFKPVNETEALAAVAAL 269

Query: 265 TSV-------ETKNVTEQPPLLFDLTGLQKEVNKKLNLSAEETLKIAQSLYEKKFITYPR 317
                     E K  T +P   F  + LQ+  + +L    ++T+ +AQ LYE  +ITY R
Sbjct: 270 NKAQYEVCKREDKPTTSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYEAGYITYMR 329

Query: 318 TGS----------------KYIPEDMWTEIPNLIRALQDRDTCKQAVAKVKWGRFNKRIV 361
           T S                K+  E      PN+  + Q+     +A+             
Sbjct: 330 TDSTNLSAEAVENLRGYITKHYGEAYLPSQPNVYGSKQNAQEAHEAIRP----------- 378

Query: 362 NDLRVTDHHGLLTTDTIPSALNAKENAVYDMIAFRLLEAISGACTKEATHITLQALHYDF 421
           +D+ V       T D +   + A  + +Y +I  + +         ++T ++++A  Y  
Sbjct: 379 SDVTV-------TADDL-EGMEADAHKLYALIWNQFVACQMTPAQYDSTTVSVKAAEYTL 430

Query: 422 TTKGCKVLEPGWRSIKGNFTDDDAEPIEDLPDIKEGDVLKIKQAAVLEKKTKPPVLYTEA 481
             KG  +   GW  ++     ++    + LP +K GD LK+      +  TKPP  YTEA
Sbjct: 431 KAKGRILKFDGWTRVQRPLGKNED---QILPPVKVGDSLKLVSLDPKQHFTKPPARYTEA 487

Query: 482 GLLSAMETAGKDIKNEEERKALQNIGIGTPATRAAIIETLFTRNYIQREKKSLIPTEKGL 541
            L+                K L+  GIG P+T A+II T+  R Y++ +++     + G 
Sbjct: 488 ALV----------------KELEKRGIGRPSTYASIISTIQDRGYVKVDQRRFFAEKMG- 530

Query: 542 QVYELVKDR------KIADVAMTAEWELALQKIETSEMNAIA--------FQKEME-AYT 586
              E+V DR       + +   TA  E  L +I   E+N  A        F +++E A  
Sbjct: 531 ---EIVTDRLDENFDDLMNYDFTARMEEKLDQIAEGEVNWTAVLDEFFADFSRDLETAEQ 587

Query: 587 KSITGELLQTSIAKDNSPELVCPKCKK 613
               G +    I   N   ++CP C +
Sbjct: 588 DESLGGMKPNHIVMTN---ILCPTCSR 611