Pairwise Alignments
Query, 1330 a.a., two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) from Bacteroides thetaiotaomicron VPI-5482
Subject, 1431 a.a., two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) from Bacteroides thetaiotaomicron VPI-5482
Score = 424 bits (1090), Expect = e-122
Identities = 345/1416 (24%), Positives = 629/1416 (44%), Gaps = 160/1416 (11%)
Query: 35 DGLNNQKIYHIQKDRRGYMWFLTQEGVDRYDGKHIKHYTFSDDSMKL---DSRIALNWLY 91
DGL N I ++ +D +G+MW T G+ YDG + D ++ + D RI +
Sbjct: 33 DGLANNSIRYMFQDSKGFMWMGTVNGLSYYDGNSFVS-IYPDPNLPISLADPRI--RNME 89
Query: 92 MDQEDVLWVIGQKGRIFRYDSQHDKFELAYVHPELIRNKFQAFLDYGYLDKNDHIWLCYK 151
D LW+ YD +H +F + + + + + + + IWL
Sbjct: 90 EDSNGFLWIATLSSLYSCYDLKHGRF-VDFTGCGEYKQSYSKKI----IASDQSIWLWDN 144
Query: 152 DT---ITWYNIRTGTTQHMPKPV-----DGAISTIEQADG-GHFFIGTGSGLFCVGIEKG 202
+ Y ++Q K + D + E D GH +IGT GL+ K
Sbjct: 145 NNGCRRVVYQDGQFSSQAYKKELGNLSSDKVLFVYESNDSPGHVWIGTKQGLWKYHDGKL 204
Query: 203 ELKQIPDE---------VVKSIVTPVHELYYHTVSKQ---------------LFVGSYK- 237
E E I+T E+Y H++S + GS +
Sbjct: 205 EAMDTQGESWEHIFSYDQYTCIITGKKEIYRHSLSNNRLEKIASLTELGDTGVITGSLRL 264
Query: 238 ---------EGILIYD--IGKTQKITPCYAPNNVEVNQIVALNADELLIATGGKGVYKLN 286
G I D GK ++ ++ N++ + N + V+ +N
Sbjct: 265 QHQWVMFTATGSYILDPVTGKLRR----FSRLNIKNGNVTRDNKGNAWVHNYTGNVWYVN 320
Query: 287 VNT--CKSEPYITADYSSYNGMNGNNINDIYVDEEERIWLANYPTGITIRNNRYGRYDLI 344
+T K ++++++ Y + + I D + IW+ Y G+ + G
Sbjct: 321 TSTGDIKHFQFLSSEHLGYIDVERYS---IIHDSRDIIWITTYGNGLFAYDLNTGDLQHF 377
Query: 345 KHSLGNNRSLVNDQVHDVIEDSDGDLWFATS-NGISFYQTDTREWCSFFSSFDPVPDDEN 403
+ ++ + ++ + +IED G +W ++ +G+S + + + + + D N
Sbjct: 378 TFEVSHSSHINSNYLQYIIEDRSGGIWVSSEFSGLSHLEILNKGTLRIYPNGEDASDRSN 437
Query: 404 ---------------------------------------HIFLALCEVSPGVIWAGGFTS 424
H ++CE + G +W G
Sbjct: 438 TIRMLLRGKNGNVYMANRMGTLYEYDADLKNILRREKFTHNVYSMCEDNEGQLWLGMRGI 497
Query: 425 GIYKIEKKKGFKISYLSPAAIAGIRPDQYIYDIKKDSSGDVWSGGYYHLKRINLETKNVR 484
G+ +I + ++ + +++ + +Y I +D G +W G + + ++T N
Sbjct: 498 GL-RIGADQWYRYNSKDNNSLS----NDNVYLIYRDRKGRMWIGTFGGGLNLAVKTGNGY 552
Query: 485 LYP-------GVSSITTILEKNARQMWIGTRMGLY--------QLDKQSGVYRYIDLPVE 529
+ G + I E MW+GT G+Y K +Y +++
Sbjct: 553 QFKHFFQDSYGEKRVRVIQEDRNGMMWVGTNNGIYIFHPDSLINSPKNYVLYNHVNETFP 612
Query: 530 SPYICALYQREDGILYIGTRGAGLLV-YDINKKKFIHQYRTDNCALISDN-----IYTII 583
S I L +G ++IGT GAG + Y N +Q+ T +C I D I +I+
Sbjct: 613 SNEIRCLVNDHEGNMWIGTTGAGFAICYPGND----YQHLTFDCYSIKDGLPNGVIQSIV 668
Query: 584 PRQDENLLMGTENGITIYSPKDHFFRNWTREQGLMSVNFNAGSATTYSNSTLVFGGNDGA 643
QD + + TE GI+ ++ N+ + ++ +A ++ L+FG N G
Sbjct: 669 EDQDNKMWIATEYGISRFTLATKQIENYYFSSHTLGNVYSENTACINADGRLLFGTNYGL 728
Query: 644 VKFPTD-IEIPEPYYSRLLLRDFMIAYHPVYPGDDGSPLKKDINETDCLELAYGQNTFSL 702
V + +E E S + + H + PG D SPL + ++ T L L + QN+F +
Sbjct: 729 VVLDANKVENMEKLASTVFTGLHINGAH-MLPGMDDSPLNETMSYTGQLNLKHYQNSFVI 787
Query: 703 DVASINYDYPSNILYSWKIDGYHKEWTRPSQDNRIVVRNLPPGSYTLQIRTVSNEEKYKT 762
++ N+ YS+++ Y EW+ PS N RNLPPG Y LQ++ + +
Sbjct: 788 AFSTFNF-LSGASKYSYRMPPYDSEWSIPSAQNLATYRNLPPGKYQLQVKACNVAGVWG- 845
Query: 763 YETRSIQIIITPPVWASMWAMVGYAILVVLIMIIIFRVI--------MLHKQKKISDEKT 814
E +++I+I PP W + WA + Y + + ++ F +I + +K++++ K
Sbjct: 846 -EESTMEIVIAPPFWQTTWAYLIYLVFIGIVCYFSFHIIRKFNRLRNRIAVEKQLTEYKL 904
Query: 815 RFFINTAHDIRTPLTLIKAPLEEVVENHMVAEKALPHMNMALKNVNTLLQLTTNLINFER 874
FF N +H+ RTPLTLI+ L +++ ++ + K+ +L+L L+ F +
Sbjct: 905 EFFTNISHEFRTPLTLIQGALNKLINIENPPKEMQRPLKTMDKSTQRMLRLINQLLEFRK 964
Query: 875 IDVYSSTLYVSEYELNSYMNDVCATFRKYAEMKRVRFVYESNFDYLNVWFDSDKMGSILK 934
+ L + E ++ +++ ++ +F+ +E K + F +E + ++ D + +
Sbjct: 965 MQKNKLALSLEETDVIAFLYEIFLSFKDTSESKNIDFSFEPSQPAYKMFIDKGNLDKVTY 1024
Query: 935 NILSNALKYTPENGSVC--ICACEEGNTWSIEVKDTGIGIPSSEQKKLFRNCFRGSNVVN 992
N+LSNA KYTP NG + I E+ I+V D GIGIP ++ +LF+ + S
Sbjct: 1025 NLLSNAFKYTPSNGKIIFKIDIQEDKQQLRIQVIDNGIGIPKEKRSELFKRFMQSS---- 1080
Query: 993 LKVTGSGIGLMLVYKLVKLHKGKIHIQSVEHQGTCVQITFPKGNTHLHKAKFISPK---- 1048
+ G+GL L ++LV++HKG I E G+ + P + + F+ P
Sbjct: 1081 FSHSSVGVGLHLTHELVQVHKGNISYDENEGGGSVFTVLLPTNSDIYQEKDFLIPNQLLT 1140
Query: 1049 TPNERMDAVVLGGTSDLPVLEAPQIKTSLQRILVVEDNDDLRNYLVDMLMAGYNIQSCSN 1108
E+ L + + P + +++L++ED+ D+R +L + + + ++ ++
Sbjct: 1141 EEEEQHSKDFLRNETSEDTFQPPVDPLNKRKVLIIEDDTDIREFLREEIGVYFEVEVAAD 1200
Query: 1109 GKDALVIIKEFNPDLVISDIMMPEMSGDELCSAIKTSVEMSHIPVILLTALGDEKNILGG 1168
G ++ DL++ D++MP M+G E+ +K SHIP+ILLTAL E+ G
Sbjct: 1201 GTSGFEKASTYDADLIVCDVLMPGMNGFEVTRKLKNEFTTSHIPIILLTALNIEEKYQEG 1260
Query: 1169 LEIGADAYITKPFSVGILKVTIKNILANRELLRQVYNSIENKEKHLPVNCTNTLDWKFIA 1228
+E GADAYITKPF+V +L I ++ R+ LRQ Y++ E H + CTN D KF
Sbjct: 1261 IESGADAYITKPFNVSLLLARIFKLIELRDKLRQKYSN-EPGLAH-SIICTNDKDQKFSV 1318
Query: 1229 SVKECIEKNMGDLDFGVDVLSNQHHMSRTSFYNKLKALTGYAPADYIRMIRLQRAAQLLK 1288
+ E + ++M D DF V+ + + RT FY K++ +TGY+P +Y+R++R+++AA++L
Sbjct: 1319 KLNEVLNEHMTDTDFSVNDFAGIMGLGRTVFYKKVRGVTGYSPYEYLRVMRMKKAAEMLL 1378
Query: 1289 QKEYTITEIAEIVGFSDAKYFREVFKKYYNVSPSKF 1324
++ TI E+A VG +D YF + FK + VSPS +
Sbjct: 1379 TEDLTIAEVAYSVGINDPFYFSKCFKNQFGVSPSAY 1414
Score = 40.4 bits (93), Expect = 1e-06
Identities = 50/211 (23%), Positives = 83/211 (39%), Gaps = 46/211 (21%)
Query: 323 WLANYPTGITIRNNRYGRYDLIKHSLGNNRSLVNDQVHDVIEDSDGDLWFATSNGISFYQ 382
+L++ + IR+N+ L L N+ + + +DS G +W T NG+S+Y
Sbjct: 14 YLSSVHASVEIRSNK----------LTTGDGLANNSIRYMFQDSKGFMWMGTVNGLSYYD 63
Query: 383 TDTREWCSFFSSFDPVPDDENHIFLA------LCEVSPGVIWAGGFTSGIYKIEKKKG-- 434
+ SF S + PD I LA + E S G +W +S + K G
Sbjct: 64 GN-----SFVSIY---PDPNLPISLADPRIRNMEEDSNGFLWIATLSSLYSCYDLKHGRF 115
Query: 435 --------FKISYLSPAAIAGIRPDQ--YIYDIKKDSSGDVWSGGYYHLKRINLETKNVR 484
+K SY I DQ +++D V+ G + + E N+
Sbjct: 116 VDFTGCGEYKQSYSKKI----IASDQSIWLWDNNNGCRRVVYQDGQFSSQAYKKELGNL- 170
Query: 485 LYPGVSSITTILEKN--ARQMWIGTRMGLYQ 513
+ + E N +WIGT+ GL++
Sbjct: 171 ---SSDKVLFVYESNDSPGHVWIGTKQGLWK 198
Score = 34.7 bits (78), Expect = 7e-05
Identities = 47/212 (22%), Positives = 83/212 (39%), Gaps = 60/212 (28%)
Query: 18 ISSAVSKGQIYKYIGLEDG-LNNQKIYHIQKDRRGYMWFLTQEG-----VDRYDGKHIKH 71
I + Q Y+Y ++ L+N +Y I +DR+G MW T G V +G KH
Sbjct: 497 IGLRIGADQWYRYNSKDNNSLSNDNVYLIYRDRKGRMWIGTFGGGLNLAVKTGNGYQFKH 556
Query: 72 YTFSDDSMKLDSRIALNWLYMDQEDVLWVIGQKGRIFRYDSQHDKFELAYVHPELIRNKF 131
+ F D + R+ + D+ ++WV G I+ + HP+ + N
Sbjct: 557 F-FQDSYGEKRVRV----IQEDRNGMMWV-GTNNGIYIF------------HPDSLINSP 598
Query: 132 QAFLDYGYLDK-----------NDH---IW---------LCYKD------TITWYNIRTG 162
+ ++ Y ++++ NDH +W +CY T Y+I+ G
Sbjct: 599 KNYVLYNHVNETFPSNEIRCLVNDHEGNMWIGTTGAGFAICYPGNDYQHLTFDCYSIKDG 658
Query: 163 TTQHMPKPVDGAISTIEQADGGHFFIGTGSGL 194
+G I +I + +I T G+
Sbjct: 659 LP-------NGVIQSIVEDQDNKMWIATEYGI 683
Score = 33.9 bits (76), Expect = 1e-04
Identities = 17/49 (34%), Positives = 28/49 (57%), Gaps = 2/49 (4%)
Query: 33 LEDGLNNQKIYHIQKDRRGYMWFLTQEGVDRYD--GKHIKHYTFSDDSM 79
++DGL N I I +D+ MW T+ G+ R+ K I++Y FS ++
Sbjct: 655 IKDGLPNGVIQSIVEDQDNKMWIATEYGISRFTLATKQIENYYFSSHTL 703