Pairwise Alignments
Query, 1330 a.a., two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) from Bacteroides thetaiotaomicron VPI-5482
Subject, 1337 a.a., two-component system sensor histidine kinase/response regulator, hybrid ('one component system') (NCBI ptt file) from Bacteroides thetaiotaomicron VPI-5482
Score = 425 bits (1092), Expect = e-122
Identities = 304/1049 (28%), Positives = 506/1049 (48%), Gaps = 75/1049 (7%)
Query: 317 DEEERIWLANYPTGITIRNNRYGRYD-LIKHSLGNNRSLVNDQVHDVIEDSDGDLWFATS 375
D E IW+ G+ NR ++D + S GN SL ++ ++ ED G++W T
Sbjct: 318 DSEGGIWIGTLFGGVNYLPNRNLQFDKFVPGSSGN--SLNTKRIRELAEDVKGNIWIGTE 375
Query: 376 N-GISFYQTDTREWCSFFSSFDPVPDDENHIFLALCEVSP--GVIWAGGFTSGIYKIEKK 432
+ GIS + V D ++ L V P I+ G F +G+ I+
Sbjct: 376 DAGISVLNVEN-------GVIRQVKDHKSGNHLVTLAVVPFQDQIYCGLFKAGLDVIQVP 428
Query: 433 KGFKISYLSPAAIAGIRPDQYIYDIKKDSSGDVWSG---GYYHLKRINLETKNVRLYPGV 489
G+ + + +P+ + Y++ I D G W G G Y + + NV+ G
Sbjct: 429 -GYTVRHYTPSELKIGEGSVYVFHI--DRKGRKWLGTGWGLYVAEAGSFNFVNVK-ETGY 484
Query: 490 SSITTILEKNARQMWIGTR-MGLYQLDKQSGVYRYIDLPVESP------YICALYQREDG 542
+ I + E +WI T G+++ Q+ Y+ + P + ++ Q G
Sbjct: 485 NWIFDLCEGKDGSVWIATMGSGVWRYSPQTDSYKKYESKENEPDGLSSNSVSSVMQDSKG 544
Query: 543 ILYIGTRGAGLLVYDINKKKFIHQYRTDNCALISDNIYTIIPRQDENLLMGTENGITIYS 602
++ T G+ Y+ K F+ + L D Y I+ ++ NL GT G+ +
Sbjct: 545 RVWFSTDRGGICYYNEEKDNFVTYSIKEG--LPDDVAYKILEDEEGNLWFGTNRGLVRFH 602
Query: 603 PKDHFFRNWTREQGLMSVNFNAGSATTYSNSTLVFGGNDGAVKFP-----TDIEIPEPYY 657
P + R +T + GL+ FN SA N FGG DG V F TD +P Y
Sbjct: 603 PDKNDIRVFTTKDGLLGNQFNYKSALKARNGKFYFGGIDGLVAFDPREAKTDDFVPPIYI 662
Query: 658 SRLLLRDFMIAYHPVYPGDDGSPLKKDINETDCLELAYGQNTFSLDVASINYDYPSNILY 717
S+ + + + H SPLK+ I TD + L Y ++ S DVA ++Y Y
Sbjct: 663 SKFSIYNKEVTVHTA-----DSPLKECITHTDRIVLNYDESNISFDVALLSYSTAEANQY 717
Query: 718 SWKIDGYHKEWTRPSQDNRIVVRNLPPGSYTLQIRTVSNEEKYKTYETRSIQIIITPPVW 777
+++ K+W + + + I LPPG YT Q++ SN+ + E RS+ I I PP W
Sbjct: 718 YYRMAPIDKDWIKAATNQNISYAKLPPGQYTFQVKATSNDNGGQFVE-RSLSIEILPPWW 776
Query: 778 ASMWAMVGYAILVVLIMIIIF---------------RVIMLHKQKKISDEKTRFFINTAH 822
S WA V Y I +V +++ F ++ + K+K++ + K FF AH
Sbjct: 777 FSPWAYVFYFIWLVCVVVSWFFWYKHRKEKEMEERQKLFEIEKEKELYESKVNFFTEIAH 836
Query: 823 DIRTPLTLIKAPLEEVVENHMVAEKALPHMNMALKNVNTLLQLTTNLINFERIDVYSSTL 882
++RTPLTLI PLE + E + K ++++ +N N LL LT L++F++I + +
Sbjct: 837 EVRTPLTLINGPLETLQEMEIADPKIQKNLSVITQNTNRLLTLTGQLLDFQKIGAHKFEM 896
Query: 883 YVSEYELNSYMNDVCATFRKYAEMKRVRFVYESNFDYLNVWFDSDKMGSILKNILSNALK 942
+ ++ S + + A F K + + D + + IL N+L+NALK
Sbjct: 897 TMECVDITSLLRETVARFEPTISKKNKELALHIPEESIEAVVDKEAITKILSNLLNNALK 956
Query: 943 YTPENGSVCICACEEGNTWSIEVKDTGIGIPSSEQKKLFRNCFRGSNVVNLKVTGSGIGL 1002
Y S+C+ E + + V G IP+ +++F ++ + + G GIGL
Sbjct: 957 YARH--SICVELQRETEAFLVRVTSDGDKIPAEISQQIFEPFYQAAKKDSASF-GVGIGL 1013
Query: 1003 MLVYKLVKLHKGKIHIQSVEHQGTCVQITFPKGNTHLHKAKFISPKTPNERMDAVVLGGT 1062
L L LH+GK+++ S EH+ ++ P L PK ++ LG
Sbjct: 1014 PLARSLASLHRGKLYLDS-EHEDNSFVLSVPLVENTLRSL----PKLEEITVETDTLG-- 1066
Query: 1063 SDLPVLEAPQIKTSLQRILVVEDNDDLRNYLVDMLMAGYNIQSCSNGKDALVIIKEFNPD 1122
+PV + + +L+VEDN+ + ++ + L+ + +++ NG++AL +++ D
Sbjct: 1067 EGVPV----EAEMKSYVLLLVEDNETMLEFMSERLLEVFTVETAKNGQEALEVLRSRRID 1122
Query: 1123 LVISDIMMPEMSGDELCSAIKTSVEMSHIPVILLTALGDEKNILGGLEIGADAYITKPFS 1182
LVISDIMMP M+G ELC IK+ +++SHIPVI LTA D + + GL+IGA+AY+ KPFS
Sbjct: 1123 LVISDIMMPVMNGWELCKEIKSDMDLSHIPVIFLTAKNDIDSKINGLKIGAEAYVEKPFS 1182
Query: 1183 VGILKVTIKNILANRELLRQVYNSIENKEKHLPVN--CTNTLDWKFIASVKECIEKNMGD 1240
LK I ++L NR+ R+ + +K P N N +D +F+ V IE+N+ D
Sbjct: 1183 FNYLKTQIVSLLYNRQKEREAF----SKRPFFPTNKMQMNKVDEEFMNKVIRTIEENIID 1238
Query: 1241 LDFGVDVLSNQHHMSRTSFYNKLKALTGYAPADYIRMIRLQRAAQLLKQKEYTITEIAEI 1300
+ V+ L+ MSR+S K+K L+ +P D+IR+IRL++AA+L+ + +Y I +I +
Sbjct: 1239 TNLNVEHLAEILGMSRSSLLRKIKMLSNLSPVDFIRLIRLRKAAELIHEGKYLIGDICFM 1298
Query: 1301 VGFSDAKYFREVFKKYYNVSPSKFVNSDQ 1329
VG + YF ++F K + ++P F Q
Sbjct: 1299 VGINSPSYFSKLFLKQFGMTPKDFEKQSQ 1327
Score = 70.9 bits (172), Expect = 8e-16
Identities = 122/602 (20%), Positives = 222/602 (36%), Gaps = 114/602 (18%)
Query: 10 LLVFIVLLISSAVSKGQIYKYIGLEDGLNNQKIYHIQKDRRGYMWFLTQEGVDRYDGKHI 69
L+ + +S + + +I ++GL++ + I +D G+MWF T+ G++R+DG I
Sbjct: 11 LVTLFLQKVSGEENSSYYFTHINGDNGLSSSNVKAIIQDSYGFMWFGTKNGLNRFDGTSI 70
Query: 70 KHYTFSDDSMKLDSRIALNWLYMDQEDVLWVIGQKGRIFRYDSQHDKFELAYVHPELIRN 129
D +K + ++ LY D LWV +G ++ Y D F +++ +
Sbjct: 71 LRMNCEDHQLKKGNN-NISALYEDANRTLWVGTDRG-VYLYHPASDVF--THINQKTKEG 126
Query: 130 K-FQAFLDYGYLDKNDHIWLC--------YKDT-ITWYNI--RTGTTQHMP--------- 168
K ++ D +IW+ YKD + +Y I R Q P
Sbjct: 127 KTMDNWVSAIVGDTQGNIWVIIPDQGIFRYKDNELYFYEISNRRQFKQESPNCICVRENG 186
Query: 169 --------------KPVDGAISTIEQADGGHFFIGTGSGLFC-------VGIEKGEL--K 205
P + + I + G +G C + +GEL
Sbjct: 187 EVWIGFWGLGICRYNPQNDSFEQIVEDRDGRPLVGKNINSICEYGDWLIMAANEGELIKY 246
Query: 206 QIPDEVVKSI-VTPVHELYYHTVS---KQLFVGSYKEGILIYDIGKTQKIT------PCY 255
V++ I V +Y TV+ ++++G++ G+ + D K + ++ +
Sbjct: 247 NTKSHVLEDIKVAGADNTFYTTVAYMKGKIWLGTF-NGLYVIDEKKNEVVSLKEDLMRSF 305
Query: 256 APNNVEVNQIVALNADELLIATGGKGVYKLNVNTCKSEPYITADYSSYNGMNGNNINDIY 315
+ ++ + + + + I T GV L + + ++ SS N +N I ++
Sbjct: 306 SLSDKMIYSMCQDSEGGIWIGTLFGGVNYLPNRNLQFDKFVPG--SSGNSLNTKRIRELA 363
Query: 316 VDEEERIWLANYPTGITIRNNRYGRYDLIK-HSLGNNRSLV-----NDQVH--------D 361
D + IW+ GI++ N G +K H GN+ + DQ++ D
Sbjct: 364 EDVKGNIWIGTEDAGISVLNVENGVIRQVKDHKSGNHLVTLAVVPFQDQIYCGLFKAGLD 423
Query: 362 VIE--------------------------DSDGDLWFATSNGISFYQTDTREWCSFFSSF 395
VI+ D G W T G+ + + F+
Sbjct: 424 VIQVPGYTVRHYTPSELKIGEGSVYVFHIDRKGRKWLGTGWGLYVAEAGS------FNFV 477
Query: 396 DPVPDDENHIFLALCEVSPGVIWAGGFTSGIYKIEKKKGFKISYLSPAAIAGIRPDQYIY 455
+ N IF LCE G +W SG+++ + Y S +
Sbjct: 478 NVKETGYNWIF-DLCEGKDGSVWIATMGSGVWRYSPQTDSYKKYESKENEPDGLSSNSVS 536
Query: 456 DIKKDSSGDVW----SGG--YYHLKRINLETKNVRLYPGVSSITTILEKNARQMWIGTRM 509
+ +DS G VW GG YY+ ++ N T +++ ILE +W GT
Sbjct: 537 SVMQDSKGRVWFSTDRGGICYYNEEKDNFVTYSIKEGLPDDVAYKILEDEEGNLWFGTNR 596
Query: 510 GL 511
GL
Sbjct: 597 GL 598
Score = 43.5 bits (101), Expect = 1e-07
Identities = 60/274 (21%), Positives = 108/274 (39%), Gaps = 29/274 (10%)
Query: 346 HSLGNNRSLVNDQVHDVIEDSDGDLWFATSNGISFYQTDT--REWCSFFSSFDPVPDDEN 403
H G+N L + V +I+DS G +WF T NG++ + + R C D N
Sbjct: 31 HINGDN-GLSSSNVKAIIQDSYGFMWFGTKNGLNRFDGTSILRMNCE-----DHQLKKGN 84
Query: 404 HIFLALCEVSPGVIWAGGFTSGIYKIEKKKGFKISYLSPAAIAGIRPDQYIYDIKKDSSG 463
+ AL E + +W G G+Y ++++ G D ++ I D+ G
Sbjct: 85 NNISALYEDANRTLWV-GTDRGVYLYHPASDV-FTHINQKTKEGKTMDNWVSAIVGDTQG 142
Query: 464 DVW----SGGYYHLKRINL---ETKNVRLYPGVSSITTILEKNARQMWIG-TRMGLYQLD 515
++W G + K L E N R + S + +N ++WIG +G+ + +
Sbjct: 143 NIWVIIPDQGIFRYKDNELYFYEISNRRQFKQESPNCICVRENG-EVWIGFWGLGICRYN 201
Query: 516 KQSGVYRYI-----DLPVESPYICALYQREDGILYIGTRGAGLLVYDINKKKFIHQYRTD 570
Q+ + I P+ I ++ + D ++ G L+ Y+ H
Sbjct: 202 PQNDSFEQIVEDRDGRPLVGKNINSICEYGDWLIMAANEGE-LIKYNTKS----HVLEDI 256
Query: 571 NCALISDNIYTIIPRQDENLLMGTENGITIYSPK 604
A + YT + + +GT NG+ + K
Sbjct: 257 KVAGADNTFYTTVAYMKGKIWLGTFNGLYVIDEK 290
Score = 41.2 bits (95), Expect = 7e-07
Identities = 48/212 (22%), Positives = 89/212 (41%), Gaps = 17/212 (8%)
Query: 457 IKKDSSGDVWSGGYYHLKR------INLETKNVRLYPGVSSITTILEKNARQMWIGTRMG 510
I +DS G +W G L R + + ++ +L G ++I+ + E R +W+GT G
Sbjct: 46 IIQDSYGFMWFGTKNGLNRFDGTSILRMNCEDHQLKKGNNNISALYEDANRTLWVGTDRG 105
Query: 511 LYQLDKQSGVYRYIDLPVE-----SPYICALYQREDGILYIGTRGAGLLVYDINKKKFIH 565
+Y S V+ +I+ + ++ A+ G +++ G+ Y N+ F
Sbjct: 106 VYLYHPASDVFTHINQKTKEGKTMDNWVSAIVGDTQGNIWVIIPDQGIFRYKDNELYFYE 165
Query: 566 QYRTDNCALISDNIYTIIPRQDENLLMGTEN-GITIYSPKDHFFRNWTREQ-GLMSVNFN 623
S N I R++ + +G GI Y+P++ F ++ G V N
Sbjct: 166 ISNRRQFKQESPN--CICVRENGEVWIGFWGLGICRYNPQNDSFEQIVEDRDGRPLVGKN 223
Query: 624 AGSATTYSNSTLVFGGNDG-AVKFPTDIEIPE 654
S Y + L+ N+G +K+ T + E
Sbjct: 224 INSICEYGD-WLIMAANEGELIKYNTKSHVLE 254
Score = 30.8 bits (68), Expect = 9e-04
Identities = 18/81 (22%), Positives = 36/81 (44%), Gaps = 1/81 (1%)
Query: 35 DGLNNQKIYHIQKDRRGYMWFLTQEGVDRYDGKHIKHYTFSDDSMKLDSRIALNWLYMDQ 94
DGL++ + + +D +G +WF T G Y + ++ L +A + D+
Sbjct: 528 DGLSSNSVSSVMQDSKGRVWFSTDRGGICYYNEEKDNFVTYSIKEGLPDDVAYK-ILEDE 586
Query: 95 EDVLWVIGQKGRIFRYDSQHD 115
E LW +G + + ++D
Sbjct: 587 EGNLWFGTNRGLVRFHPDKND 607
Score = 30.4 bits (67), Expect = 0.001
Identities = 15/46 (32%), Positives = 25/46 (54%), Gaps = 2/46 (4%)
Query: 33 LEDGLNNQKIYHIQKDRRGYMWFLTQEGVDRY--DGKHIKHYTFSD 76
+++GL + Y I +D G +WF T G+ R+ D I+ +T D
Sbjct: 570 IKEGLPDDVAYKILEDEEGNLWFGTNRGLVRFHPDKNDIRVFTTKD 615