Pairwise Alignments

Query, 782 a.a., DNA topoisomerase I (NCBI ptt file) from Bacteroides thetaiotaomicron VPI-5482

Subject, 865 a.a., type I DNA topoisomerase from Escherichia coli ECOR38

 Score =  405 bits (1040), Expect = e-117
 Identities = 245/617 (39%), Positives = 353/617 (57%), Gaps = 77/617 (12%)

Query: 1   MQKNLVIVESPAKAKTIEKFLGKDFKVLSSYGHIRDL----------------------K 38
           M K LVIVESPAKAKTI K+LG D+ V SS GHIRDL                      K
Sbjct: 1   MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60

Query: 39  KKE-------FSIDVDKNFKPDYEIPADKKALVSTLKAEAKEAETVWLASDEDREGEAIA 91
           K E         +D   N++  YE+   K+ +VS LK  A++A+ ++LA+D DREGEAIA
Sbjct: 61  KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120

Query: 92  WHLYEVLKLKPENTKRIVFHEITKGAILKAIEQPRNIDLNLVNAQQARRILDRIVGFELS 151
           WHL EV+        R+VF+EITK AI +A  +P  ++++ VNAQQARR +DR+VG+ +S
Sbjct: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180

Query: 152 PVLWRKVKPSLSAGRVQSVAVRLIVEREREIHAFKSEAAYRVIAIFLVPDTDGKLVEMKA 211
           P+LW+K+   LSAGRVQSVAVRL+VEREREI AF  E  + V A    P  +   +++  
Sbjct: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240

Query: 212 ELSR--RIKTKEEAKAFLDACKGATFTIEDITTRPVKKTPPAPFTTSTLQQEAARKLGYT 269
           +  +  R   +E+ +A +   + A +++ +   +P    P APF TSTLQQ A+ +LG+ 
Sbjct: 241 QNDKPFRPVNREQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300

Query: 270 VAQTMMIAQRLYESGFITYMRTDSVNLSEYATASSKDAIIQMMGERYV--HPRHFETKTK 327
           V +TMM+AQRLYE+G+ITYMRTDS NLS+ A    +  I    G++Y+   P  + +K +
Sbjct: 301 VKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASK-E 359

Query: 328 GAQEAHEAIRPT---YMENQSIEGTAQEKKLYDLIWKRTIASQMADAELEKTTATISISK 384
            +QEAHEAIRP+    M     +  A  +KLY LIW++ +A QM  A+ + TT T+    
Sbjct: 360 NSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVG--- 416

Query: 385 SGD-AFTAIGEVIKFDGFLRVYRESYDDENEQEDESRLLPPLKKGQKLEYGPIVATERFT 443
           +GD    A G +++FDG+ +V          + DE R+LP + KG  L    +   + FT
Sbjct: 417 AGDFRLKARGRILRFDGWTKVM-----PALRKGDEDRILPAVDKGDALTLVELTPAQHFT 471

Query: 444 QRPPRYTEASLVRKLEELGIGRPSTYAPTISTIQQREYVEKGNKDGEERTFNVLTLKDNQ 503
           + P R++EASLV++LE+ GIGRPSTYA  ISTIQ R YV                     
Sbjct: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVR-------------------- 511

Query: 504 IKDESHNEVTGAEKSKLFPTDTGTVVNDFLTEYFPDILDYNFTASVEKEFDEIAEGEVKW 563
                       E  + +    G +V D L E F ++++Y+FTA +E   D++A  E +W
Sbjct: 512 -----------VENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEW 560

Query: 564 TSIMKTFYDQFHPAVEK 580
            +++  F+  F   ++K
Sbjct: 561 KTVLDHFFSDFTQQLDK 577