Pairwise Alignments
Query, 1420 a.a., two-component system sensor histidine kinase/response regulator, hybrid ('one component system') (NCBI ptt file) from Bacteroides thetaiotaomicron VPI-5482
Subject, 1431 a.a., two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) from Bacteroides thetaiotaomicron VPI-5482
Score = 445 bits (1144), Expect = e-128
Identities = 330/1204 (27%), Positives = 569/1204 (47%), Gaps = 176/1204 (14%)
Query: 242 VWISS-DRGLFRYNKTGNVIKRYEHDSGNPYSLSQNYLTNLAITDDKQ---LIVATLRGI 297
+WI++ GLF Y+ ++ + + + ++ NYL I +D+ + + G+
Sbjct: 355 IWITTYGNGLFAYDLNTGDLQHFTFEVSHSSHINSNYLQY--IIEDRSGGIWVSSEFSGL 412
Query: 298 NIYNPMTDNFERIACDLPNGGTNLLNSNFINCILTDGEHIWFGTETGGINLLNPRQLSIR 357
+ + RI PNG SN I +L + G + + N R ++
Sbjct: 413 SHLEILNKGTLRI---YPNGEDASDRSNTIRMLLRG--------KNGNVYMAN-RMGTLY 460
Query: 358 SYRHDKEN---PSSLSYNPVNAIYEDVYGTLWVGTVEGGLNRKERNSEDFTHYTREHGGL 414
Y D +N ++N V ++ ED G LW+G G+ + + + + ++++ L
Sbjct: 461 EYDADLKNILRREKFTHN-VYSMCEDNEGQLWLGM--RGIGLRIGADQWYRYNSKDNNSL 517
Query: 415 SHNSVSALTADTDNHLWIGTWGGGLNLLDLKAPRQILEVISSQTGGGFPINFIGVLNYDP 474
S+++V + D +WIGT+GGGLNL + +TG G+
Sbjct: 518 SNDNVYLIYRDRKGRMWIGTFGGGLNL-------------AVKTGNGYQFKH-------- 556
Query: 475 INEGIWIGANQGLYFYDPVKKEITAPLPDKAAENIHGCIGSIIDKEGKLWVGCLEGVYII 534
+F D ++ + + D+ G +WVG G+YI
Sbjct: 557 -------------FFQDSYGEKRVRVIQE--------------DRNGMMWVGTNNGIYIF 589
Query: 535 DLHS--RSSKGEFQYRHLNYKLDDPSSRLIEKITCFYQGKDGTLWLGSNGYGIYQRKIDA 592
S S K Y H+N PS+ +I C +G +W+G+ G G I
Sbjct: 590 HPDSLINSPKNYVLYNHVNETF--PSN----EIRCLVNDHEGNMWIGTTGAGF---AICY 640
Query: 593 QGKEQ----FISYSTAQGLPNNSVRGILEDNNGNLWISTNNGLSCYHQAENRFINYTIQD 648
G + F YS GLPN ++ I+ED + +WI+T G+S + A + NY
Sbjct: 641 PGNDYQHLTFDCYSIKDGLPNGVIQSIVEDQDNKMWIATEYGISRFTLATKQIENYYFSS 700
Query: 649 GLIDTQFYWNASCGSSHDLLYFGSVGGLVAIESNRPAMSLPAAKVRFTRLRIGNEEILPG 708
+ + N +C ++ L FG+ GLV +++N+ A FT L I +LPG
Sbjct: 701 HTLGNVYSENTACINADGRLLFGTNYGLVVLDANKVENMEKLASTVFTGLHINGAHMLPG 760
Query: 709 SEY--LSEDIAITTELKLHEKEKSFSLEFAALNFESNNTAIYSYRLVGFDDKWVQVPGNR 766
+ L+E ++ T +L L + SF + F+ NF S + YSYR+ +D +W +P +
Sbjct: 761 MDDSPLNETMSYTGQLNLKHYQNSFVIAFSTFNFLSGASK-YSYRMPPYDSEW-SIPSAQ 818
Query: 767 RFASYTNLPPGSYTLQVRYTPDGENEGENITELKITIVPYFYKTVWFILFIIVLLSVSVW 826
A+Y NLPPG Y LQV+ GE T ++I I P F++T W L +V + + V
Sbjct: 819 NLATYRNLPPGKYQLQVKACNVAGVWGEEST-MEIVIAPPFWQTTWAYLIYLVFIGI-VC 876
Query: 827 QFYQWRIRNLKRQKEYLHRTVEERTHELEQQKHLLENQTDELSRQNQMLIQQNEKITRQK 886
F IR R + N++ +++
Sbjct: 877 YFSFHIIRKFNRLR-------------------------------NRIAVEK-------- 897
Query: 887 AQLIRMSRKVQELTLDKISFFTNITHEFRTPITLIIGPIERALKLSYNPQVIEQ-LNFVE 945
+LT K+ FFTNI+HEFRTP+TLI G + + + + P+ +++ L ++
Sbjct: 898 -----------QLTEYKLEFFTNISHEFRTPLTLIQGALNKLINIENPPKEMQRPLKTMD 946
Query: 946 RNSKYLLSLVNQLMDFRKVESGKLEIVKTRGNFLKFIDSLITPFEVFAQERNIVLKRYYR 1005
++++ +L L+NQL++FRK++ KL + + + F+ + F+ ++ +NI
Sbjct: 947 KSTQRMLRLINQLLEFRKMQKNKLALSLEETDVIAFLYEIFLSFKDTSESKNIDFSFEPS 1006
Query: 1006 MEMPEILYDEEAMRKVVTNLLSNAIKFTPNGGTVSLYLSALFAKDSEKETLYICVKDSGS 1065
++ D+ + KV NLLSNA K+TP+ G + + +K+ L I V D+G
Sbjct: 1007 QPAYKMFIDKGNLDKVTYNLLSNAFKYTPSNGKIIFKIDI----QEDKQQLRIQVIDNGI 1062
Query: 1066 GIPEEDLNRIFNRFYQSQNQVKYPVYGQAGTGIGLYLCKRIVQMHGGEIKAFNNRHAGCS 1125
GIP+E + +F RF QS + + G+GL+L +VQ+H G I N G
Sbjct: 1063 GIPKEKRSELFKRFMQSS-------FSHSSVGVGLHLTHELVQVHKGNISYDENEGGGSV 1115
Query: 1126 FRILLPLQRNERKDEKTIIIDH---------------NDSSATPVQDSGSPKEKEALSIL 1170
F +LLP + +++ +I + N++S Q P K +L
Sbjct: 1116 FTVLLPTNSDIYQEKDFLIPNQLLTEEEEQHSKDFLRNETSEDTFQPPVDPLNKR--KVL 1173
Query: 1171 VVEDNADMRGYIRSILREQYHVLEAANGEEALHILNSNPIDFIISDLMMPVMDGIELSRR 1230
++ED+ D+R ++R + + V AA+G ++ D I+ D++MP M+G E++R+
Sbjct: 1174 IIEDDTDIREFLREEIGVYFEVEVAADGTSGFEKASTYDADLIVCDVLMPGMNGFEVTRK 1233
Query: 1231 VKETFAISHIPFLMLTAKTSQEARLESYRMGVDEYLLKPFDETLLLARIQNILENRKRYQ 1290
+K F SHIP ++LTA +E E G D Y+ KPF+ +LLLARI ++E R + +
Sbjct: 1234 LKNEFTTSHIPIILLTALNIEEKYQEGIESGADAYITKPFNVSLLLARIFKLIELRDKLR 1293
Query: 1291 RKFTLDMDVDVLNMEEESGDKKFLNQVMEVIKENYKNSYFEVSDFCEAVGVSKSLLNKKL 1350
+K++ + + + D+KF ++ EV+ E+ ++ F V+DF +G+ +++ KK+
Sbjct: 1294 QKYSNEPGLAHSIICTNDKDQKFSVKLNEVLNEHMTDTDFSVNDFAGIMGLGRTVFYKKV 1353
Query: 1351 QNLIGQSAGQFIRNYRLNIARELILKNRETKNMNIAEVAYEVGFNDPKYFTRCFTKHFNV 1410
+ + G S +++R R+ A E++L T+++ IAEVAY VG NDP YF++CF F V
Sbjct: 1354 RGVTGYSPYEYLRVMRMKKAAEMLL----TEDLTIAEVAYSVGINDPFYFSKCFKNQFGV 1409
Query: 1411 TPSA 1414
+PSA
Sbjct: 1410 SPSA 1413
Score = 108 bits (269), Expect = 5e-27
Identities = 142/617 (23%), Positives = 252/617 (40%), Gaps = 72/617 (11%)
Query: 36 VTMNEGLPHNFIDDLYKDSRGFMWISTAGGGLSRYDGYEFVN-YTPNNHQCKLKSNFIRN 94
+T +GL +N I +++DS+GFMW+ T G LS YDG FV+ Y N L IRN
Sbjct: 29 LTTGDGLANNSIRYMFQDSKGFMWMGTVNG-LSYYDGNSFVSIYPDPNLPISLADPRIRN 87
Query: 95 VCEDAFQRLWIVSEGGTDIIDLSTLKPIIPHDPKGILPKILELPATRIMKDTQGCIWL-H 153
+ ED+ LWI + + + LK D G + + + +I+ Q IWL
Sbjct: 88 MEEDSNGFLWIATL--SSLYSCYDLKHGRFVDFTGC-GEYKQSYSKKIIASDQS-IWLWD 143
Query: 154 CDNALHRIEFND--------KGEVQILSTLSPVYLNGPDIALKDIDEDGKIWMGNNGEIR 205
+N R+ + D K E+ LS+ +++ + D G +W+G +
Sbjct: 144 NNNGCRRVVYQDGQFSSQAYKKELGNLSSDKVLFV------YESNDSPGHVWIGTKQGLW 197
Query: 206 KVALSPQKRLVTTPIADCLKFEAGTYISDFLSKENEVWISSDRGLFRYNKTGNVIKRYEH 265
K + + T + ++ F + I+ + ++R++ + N +++
Sbjct: 198 KYHDGKLEAMDT---------QGESWEHIFSYDQYTCIITGKKEIYRHSLSNNRLEKI-- 246
Query: 266 DSGNPYSLSQNYLTNLAITDDKQLIVATLRGINIYNPMTDNFERIA-CDLPNGGTNLLNS 324
+ L + ++ Q ++ T G I +P+T R + ++ NG N
Sbjct: 247 --ASLTELGDTGVITGSLRLQHQWVMFTATGSYILDPVTGKLRRFSRLNIKNGNVTRDNK 304
Query: 325 NFINCILTDGEHIWFGTETGGINLLNPRQLSIRSYRHDKENPSSLSYNPVN--AIYEDVY 382
+ W TG + +N I+ ++ + L Y V +I D
Sbjct: 305 G----------NAWVHNYTGNVWYVNTSTGDIKHFQF--LSSEHLGYIDVERYSIIHDSR 352
Query: 383 GTLWVGTVEGGLNRKERNSEDFTHYTREHGGLSH---NSVSALTADTDNHLWIGTWGGGL 439
+W+ T GL + N+ D H+T E SH N + + D +W+ + GL
Sbjct: 353 DIIWITTYGNGLFAYDLNTGDLQHFTFEVSHSSHINSNYLQYIIEDRSGGIWVSSEFSGL 412
Query: 440 NLLDLKAPRQILEVISSQTGGGFPINFIGVLNYDPINEGIWIGANQG-LYFYDPVKKEIT 498
+ L++ + L + + N I +L N +++ G LY YD K I
Sbjct: 413 SHLEI-LNKGTLRIYPNGEDASDRSNTIRMLLRGK-NGNVYMANRMGTLYEYDADLKNIL 470
Query: 499 APLPDKAAENIHGCIGSIIDKEGKLWVGCLEGVYIIDLHSRSSKGEFQYRHLNYKLDDPS 558
+ + H D EG+LW+G + G+ + G Q+ N K D +
Sbjct: 471 -----RREKFTHNVYSMCEDNEGQLWLG-MRGIGL-------RIGADQWYRYNSK--DNN 515
Query: 559 SRLIEKITCFYQGKDGTLWLGSNGYGIYQRKIDAQGKEQFISYSTAQGLPNNSVRGILED 618
S + + Y+ + G +W+G+ G G+ G + + + G VR I ED
Sbjct: 516 SLSNDNVYLIYRDRKGRMWIGTFGGGLNLAVKTGNGYQFKHFFQDSYG--EKRVRVIQED 573
Query: 619 NNGNLWISTNNGLSCYH 635
NG +W+ TNNG+ +H
Sbjct: 574 RNGMMWVGTNNGIYIFH 590
Score = 47.8 bits (112), Expect = 8e-09
Identities = 29/89 (32%), Positives = 45/89 (50%), Gaps = 3/89 (3%)
Query: 33 ITYVTMNEGLPHNFIDDLYKDSRGFMWISTAGGGLS-RYDGYEFVNYTPNNHQCK--LKS 89
+ Y +NE P N I L D G MWI T G G + Y G ++ + T + + K L +
Sbjct: 602 VLYNHVNETFPSNEIRCLVNDHEGNMWIGTTGAGFAICYPGNDYQHLTFDCYSIKDGLPN 661
Query: 90 NFIRNVCEDAFQRLWIVSEGGTDIIDLST 118
I+++ ED ++WI +E G L+T
Sbjct: 662 GVIQSIVEDQDNKMWIATEYGISRFTLAT 690
Score = 45.8 bits (107), Expect = 3e-08
Identities = 60/291 (20%), Positives = 111/291 (38%), Gaps = 67/291 (23%)
Query: 39 NEGLPHNFIDDLYKDSRGFMWISTAGGGLS----RYDGYEFVNYTPNNHQCKLKSNFIRN 94
N L ++ + +Y+D +G MWI T GGGL+ +GY+F ++ +++ K +R
Sbjct: 514 NNSLSNDNVYLIYRDRKGRMWIGTFGGGLNLAVKTGNGYQFKHFFQDSYGEKR----VRV 569
Query: 95 VCEDAFQRLWIVSEGGTDIIDLSTLKPIIPHDPKGILPKILELPATRIMKDTQGCIWLHC 154
+ ED +W+ + G I +L + P ++ +
Sbjct: 570 IQEDRNGMMWVGTNNGIYIFHPDSL---------------INSPKNYVLYN--------- 605
Query: 155 DNALHRIEFNDKGEVQILSTLSPVYLNGPDIALKDIDEDGKIWMGNNGEIRKVALSPQKR 214
H E E++ L D +G +W+G G +
Sbjct: 606 ----HVNETFPSNEIRCLVN----------------DHEGNMWIGTTGAGFAICYPGNDY 645
Query: 215 LVTTPIADCLKFE----AGTYISDFLSKENEVWISSDRGLFRYNKTGNVIKRY---EHDS 267
T DC + G S ++N++WI+++ G+ R+ I+ Y H
Sbjct: 646 QHLT--FDCYSIKDGLPNGVIQSIVEDQDNKMWIATEYGISRFTLATKQIENYYFSSHTL 703
Query: 268 GNPYSLSQNYLTNLAITDDKQLIVATLRGINIYNP-MTDNFERIACDLPNG 317
GN YS + I D +L+ T G+ + + +N E++A + G
Sbjct: 704 GNVYSEN-----TACINADGRLLFGTNYGLVVLDANKVENMEKLASTVFTG 749
Score = 40.0 bits (92), Expect = 2e-06
Identities = 51/192 (26%), Positives = 81/192 (42%), Gaps = 30/192 (15%)
Query: 458 TGGGFPINFIGVLNYDPINEG-IWIGANQGLYFYDPVKKEITAPLPDKAAENIHGCIGSI 516
TG G N I + D ++G +W+G GL +YD P P+ I ++
Sbjct: 31 TGDGLANNSIRYMFQD--SKGFMWMGTVNGLSYYDGNSFVSIYPDPNLPISLADPRIRNM 88
Query: 517 I-DKEGKLWVGCLEGVY-IIDL-HSR----SSKGEFQYRHLNYKLDDPSSRLIEKITCFY 569
D G LW+ L +Y DL H R + GE++ + S ++I
Sbjct: 89 EEDSNGFLWIATLSSLYSCYDLKHGRFVDFTGCGEYKQSY--------SKKII------- 133
Query: 570 QGKDGTLWLGSNGYGIYQRKIDAQGKEQFISYSTAQG-LPNNSVRGILEDNN--GNLWIS 626
D ++WL N G +R + G+ +Y G L ++ V + E N+ G++WI
Sbjct: 134 -ASDQSIWLWDNNNGC-RRVVYQDGQFSSQAYKKELGNLSSDKVLFVYESNDSPGHVWIG 191
Query: 627 TNNGLSCYHQAE 638
T GL YH +
Sbjct: 192 TKQGLWKYHDGK 203