Pairwise Alignments
Query, 1420 a.a., two-component system sensor histidine kinase/response regulator, hybrid ('one component system') (NCBI ptt file) from Bacteroides thetaiotaomicron VPI-5482
Subject, 1345 a.a., two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) from Bacteroides thetaiotaomicron VPI-5482
Score = 452 bits (1162), Expect = e-130
Identities = 389/1426 (27%), Positives = 655/1426 (45%), Gaps = 176/1426 (12%)
Query: 38 MNEGLPHNFIDDLYKDSRGFMWISTAGGGLSRYDGYEFVNY-TPNNHQCKLKSNFIRNVC 96
+ +GL HN + +DS GF+W+ T+ G L+RYDG Y N + L++NF+ +
Sbjct: 31 VEDGLSHNTVWCAIQDSYGFIWLGTSDG-LNRYDGRGNKVYRNVLNDKFSLENNFVEALI 89
Query: 97 EDAFQRLWIVSEGGTDIIDLSTLKPIIPHDPKGILPKILELPATRIMKDTQGCIWLHCDN 156
E+ Q +W+ + G I D +T + D + +I+K G +W+
Sbjct: 90 EED-QNIWVGTNSGLYIYDRATDR-FSYFDKTTQYGVYVSSEIKKIVKTENGLLWI-ATL 146
Query: 157 ALHRIEFNDKGEVQILSTLSP--------------VYLNGPDIALKDIDEDGKIWMGNNG 202
++ K EV +++ VY++ L DE+GK
Sbjct: 147 GQGLFIYDPKTEVLTQNSIQTSFVWDVCQSYDKKKVYVSSLQEGLLCFDENGKFL----- 201
Query: 203 EIRKVALSPQKRLVTTPIADCLKFEAGTYISDFLSKENEVWISSDRGLF-RYNKTGNVIK 261
Q V++ + ++ I+ L E EVW+ + L R N+ ++
Sbjct: 202 ---------QSYRVSSDVNSSDSYK----INCVLDVEGEVWLGAGNNLLGRLNRQTGTVE 248
Query: 262 RYEHDSGNPYSLSQNYLTNLAITDDKQLIVATLRGINIYNPMTDNFERIACDLPNGGTNL 321
Y S L+ + +L + +L+V T G+ ++N + F R D P
Sbjct: 249 NYMAPS-----LNFGAVRSLLKYTENELLVGTDNGLYLFNRESKTFLR--ADNP-ADPRS 300
Query: 322 LNSNFINCILTDGEH-IWFGTETGGINLLNPRQLSIRSYRHDKENPSSLSY-----NPVN 375
L+ IN ++ D E +W T GGIN + S ++ R D +P+ LS V
Sbjct: 301 LSDQTINGMMWDAEGALWVLTNLGGINYM-----SKQTKRFDYYSPAYLSGIAGAGEVVG 355
Query: 376 AIYEDVYGTLWVGTVEGGLNRKERNSEDFTHYTREHGGLSHNS--VSALTADTDNHLWIG 433
E+ G +W+GT + GL + + + Y GG+ + +L D D LWIG
Sbjct: 356 PFCENKDGNIWIGT-QSGLYFFNTVTRELSEY--HIGGVKSQKYDIRSLMLDGDC-LWIG 411
Query: 434 TWGGGLNLLDLKAPRQILEVISSQTGGGFPINFIG---VLNYDPINEGIWIGANQGLYFY 490
T+ G+ +L+L+ I E S+ G P + Y I++G + GL Y
Sbjct: 412 TYAEGIRVLNLRTG-SIKEYTHSR---GIPNTICSNDVLCIYKDRKGEIFVGTSWGLCRY 467
Query: 491 DPVKKEITAPLPDKAAENIHGC--IGSIIDKEGKLWVGCLEGVYIIDLHSRSSKGEFQY- 547
+P A+N IGS+I G ++ ++I +S G F Y
Sbjct: 468 NP------------DADNFMTITSIGSMISV-GDIYEDMYNNLWIATTNS----GVFSYN 510
Query: 548 ------RHLNYKLDDPSSRLIEKITCFYQGKDGTLWLGSNGYGIYQRKIDAQGKEQFISY 601
+H ++ +D ++ + ++ G +W G+NG G+ D + E FI +
Sbjct: 511 TLSGHWKHFQHEREDSTTITSNSVITVFEDNKGVMWFGTNGGGLCS--FDPK-TEAFIEF 567
Query: 602 STAQGLPNNSVRGILEDNNGNLWISTNNGLSCYHQ-AENRFINYTIQDGLIDTQFYWNAS 660
+A LPN + I +D G+ WIS+N G+ + ++ F +TI DGL QF +S
Sbjct: 568 DSA--LPNKVIYSIEQDQTGDFWISSNAGIFKINPISKAHFRQFTINDGLQGNQFMARSS 625
Query: 661 CGSSHDLLYFGSVGGLVAIESNRPAMSLPAAKVRFTRLRIG---NEEILPGSEYLSEDIA 717
SS LYFG + G + R + V T +R+ +E+ + L + I
Sbjct: 626 LKSSEGKLYFGGINGFNVFQPERFVDNSYIPPVYVTDIRLSYLNDEQEVKKLLQLGKPIY 685
Query: 718 ITTELKLHEKEKSFSLEFAALNFESNNTAIYSYRLVGFDDKWVQVPGNRRFASYTNLPPG 777
+ ++ L + SF++ F AL++E YSY L G D +W+ N ASYTNLPPG
Sbjct: 686 MADKITLSYENNSFTIRFVALSYEDPARNRYSYMLKGVDKEWITNSENNS-ASYTNLPPG 744
Query: 778 SYTLQVRYTPDGENEGENITELKITIVPYFYKTVW-FILFIIVLLSVSVWQFYQWRIRNL 836
Y +VR + + E T L++ I P ++++ + + ++I++L+ VW ++W NL
Sbjct: 745 EYEFEVRGSNNDHQWNEKTTTLRVVITPPWWRSSFAYFIYILLLMGWIVWIAWRW---NL 801
Query: 837 KRQKEYLHRTVEERTHELEQQKHLLENQTDELSRQNQMLIQQNEKITRQKAQLIRMSRKV 896
+ + +Y HR +K Q+ K
Sbjct: 802 RVKHKYKHRM--------------------------------------EKYQIA----KE 819
Query: 897 QELTLDKISFFTNITHEFRTPITLIIGPIERALKLSYNPQVIEQLNFVERNSKYLLSLVN 956
QE+ KI FF N+ HE RTP++LI P+E+ ++ + + + L+ +++N YLL + N
Sbjct: 820 QEVYKSKIGFFINLVHEIRTPLSLIRLPLEKLQEIEHEGKEAKYLSVIDKNVNYLLGITN 879
Query: 957 QLMDFRKVESGKLEIVKTRGNFLKFIDSLITPFEVFAQERNIVLKRYYRMEMPEILYDEE 1016
QL+DF+K+E+G L++ + + ++ + + F A+ + I L + + D E
Sbjct: 880 QLLDFQKMENGALQLNLVSCDIKEIVNDVYSQFTSPAELKGIELVLTLPEQELVSMVDRE 939
Query: 1017 AMRKVVTNLLSNAIKFTPNGGTVSLYLSALFAKDSEKETLYICVKDSGSGIPEEDLNRIF 1076
+ K++ NL+ NAIK+ + L + D+ E I V D G G+P+ +IF
Sbjct: 940 KLSKILVNLMGNAIKYARTRIDLKLVTT-----DAGYE---IYVSDDGRGVPDAQKGKIF 991
Query: 1077 NRFYQSQNQVKYPVYGQAGTGIGLYLCKRIVQMHGGEIKAFNNRHAGCSFRILLPLQRNE 1136
FYQ + V GTGIGL K + + H G ++ +N G SF + LPL +
Sbjct: 992 EAFYQMPDD---KVATATGTGIGLAFAKSLAEAHQGSLRLEDNEPQGSSFILSLPLSEKK 1048
Query: 1137 RKDEKTIIIDH--NDSSATPVQDSGSPKEKEALSILVVEDNADMRGYIRSILREQYHVLE 1194
++ I+ H N+ SA + S K+ ++L+VEDN ++ R L + VL+
Sbjct: 1049 AEEAADIVEVHSENEGSAENIPSEFSGKK---FTVLLVEDNVELLNLTRDSLVAWFRVLK 1105
Query: 1195 AANGEEALHILNSNPIDFIISDLMMPVMDGIELSRRVKETFAISHIPFLMLTAKTSQEAR 1254
A NG AL IL +D I+SD+MMP M+G+EL +VK SHIP ++LTAKT+ E++
Sbjct: 1106 APNGRAALEILEQESVDVIVSDVMMPEMNGLELCSKVKSEIDYSHIPVILLTAKTTLESK 1165
Query: 1255 LESYRMGVDEYLLKPFDETLLLARIQNILENRKRYQR-KFTLDMDVDVLNME--EESGDK 1311
+E G D Y+ KPF L +I+N+L R+ + + +L + + + E D
Sbjct: 1166 VEGLECGADVYIEKPFSIKQLHKQIENLLRLRQSFHKLMVSLSGNANQASAELAMTQRDC 1225
Query: 1312 KFLNQVMEVIKENYKNSYFEVSDFCEAVGVSKSLLNKKLQNLIGQSAGQFIRNYRLNIAR 1371
+F+ ++ EVI + + F + E + +S+S +K++ L G S +++ R+N A
Sbjct: 1226 EFVAKIQEVIADQLADENFSIDTLAEQMNMSRSNFYRKIKALSGMSPNDYLKALRMNKAA 1285
Query: 1372 ELILKNRETKNMNIAEVAYEVGFNDPKYFTRCFTKHFNVTPSALLN 1417
ELI I+EVA +VGF YF +CF + V P +N
Sbjct: 1286 ELI-----QGGTRISEVAAQVGFTSSSYFAKCFKAQYGVLPKEYVN 1326
Score = 95.5 bits (236), Expect = 3e-23
Identities = 144/659 (21%), Positives = 240/659 (36%), Gaps = 171/659 (25%)
Query: 25 ERFADRYNITYVTMNEGL-PHNFIDDLYKDSRGFMWISTAGGGLSRYDGYEFVNYTPNNH 83
+R DR++ T G+ + I + K G +WI+T G GL YD V T N+
Sbjct: 107 DRATDRFSYFDKTTQYGVYVSSEIKKIVKTENGLLWIATLGQGLFIYDPKTEV-LTQNS- 164
Query: 84 QCKLKSNFIRNVCEDAFQRLWIVSEGGTDIIDLSTLKPIIPHDPKGILPKILELPATRIM 143
++++F+ +VC+ ++ VS S + ++ D G L + R+
Sbjct: 165 ---IQTSFVWDVCQSYDKKKVYVS---------SLQEGLLCFDENGKF-----LQSYRVS 207
Query: 144 KDTQGCIWLHCDNALHRIEFNDKGEVQILSTLSPVYLNGPDIALKDIDEDGKIWMGNNGE 203
D + +D ++ + +D +G++W+G
Sbjct: 208 SD---------------VNSSDSYKINCV-----------------LDVEGEVWLGAGNN 235
Query: 204 IRKVALSPQKRLVTTPIADCLKFEAGTYISDFLSKENEVWISSDRGLFRYNKTGNVIKRY 263
+ L+ Q V +A L F G S ENE+ + +D GL+ +N+ R
Sbjct: 236 LLG-RLNRQTGTVENYMAPSLNF--GAVRSLLKYTENELLVGTDNGLYLFNRESKTFLRA 292
Query: 264 EHDSGNPYSLSQNYLTNLAITDDKQLIVAT-LRGINIYNPMTDNFERIA----------- 311
++ + +P SLS + + + L V T L GIN + T F+ +
Sbjct: 293 DNPA-DPRSLSDQTINGMMWDAEGALWVLTNLGGINYMSKQTKRFDYYSPAYLSGIAGAG 351
Query: 312 ------CDLPNG--------GTNLLNS-----------------NFINCILTDGEHIWFG 340
C+ +G G N+ I ++ DG+ +W G
Sbjct: 352 EVVGPFCENKDGNIWIGTQSGLYFFNTVTRELSEYHIGGVKSQKYDIRSLMLDGDCLWIG 411
Query: 341 TETGGINLLNPRQLSIRSYRHDKENPSSL-------------------------SYNP-- 373
T GI +LN R SI+ Y H + P+++ YNP
Sbjct: 412 TYAEGIRVLNLRTGSIKEYTHSRGIPNTICSNDVLCIYKDRKGEIFVGTSWGLCRYNPDA 471
Query: 374 --------------VNAIYEDVYGTLWVGTVEGGL---NRKERNSEDFTHYTREHGGLSH 416
V IYED+Y LW+ T G+ N + + F H + ++
Sbjct: 472 DNFMTITSIGSMISVGDIYEDMYNNLWIATTNSGVFSYNTLSGHWKHFQHEREDSTTITS 531
Query: 417 NSVSALTADTDNHLWIGTWGGGLNLLDLKAPRQILEVISSQTGGGFPINFIGVLNYDPIN 476
NSV + D +W GT GGGL D K I + P I + D
Sbjct: 532 NSVITVFEDNKGVMWFGTNGGGLCSFDPKTEAFI------EFDSALPNKVIYSIEQDQTG 585
Query: 477 EGIWIGANQGLYFYDPVKKE--ITAPLPDKAAENIHGCIGSIIDKEGKLWVGCLEG---- 530
+ WI +N G++ +P+ K + D N S+ EGKL+ G + G
Sbjct: 586 D-FWISSNAGIFKINPISKAHFRQFTINDGLQGNQFMARSSLKSSEGKLYFGGINGFNVF 644
Query: 531 -------------VYIIDLHSRSSKGEFQYRHLNYKLDDPSSRLIEKITCFYQGKDGTL 576
VY+ D+ E + + L +L P + +KIT Y+ T+
Sbjct: 645 QPERFVDNSYIPPVYVTDIRLSYLNDEQEVKKL-LQLGKP-IYMADKITLSYENNSFTI 701
Score = 49.3 bits (116), Expect = 3e-09
Identities = 98/422 (23%), Positives = 173/422 (40%), Gaps = 46/422 (10%)
Query: 261 KRYEHDSGNPYSLSQNYLTNLAITDDKQLI-VATLRGINIYNPMTDNFERIACDLPNGGT 319
K+Y+ + G LS N + AI D I + T G+N Y+ + R ++ N
Sbjct: 27 KKYQVEDG----LSHNTVW-CAIQDSYGFIWLGTSDGLNRYDGRGNKVYR---NVLNDKF 78
Query: 320 NLLNSNFINCILTDGEHIWFGTETGGINLLNPRQLSIRSYRHDKENPSSLSYNPVNAIYE 379
+L N NF+ ++ + ++IW GT +G + R SY + + I +
Sbjct: 79 SLEN-NFVEALIEEDQNIWVGTNSG--LYIYDRATDRFSYFDKTTQYGVYVSSEIKKIVK 135
Query: 380 DVYGTLWVGTVEGGLNRKERNSEDFTHYTREHGGLSHNSVSALTADTD-NHLWIGTWGGG 438
G LW+ T+ GL + +E T + + V + D +++ + G
Sbjct: 136 TENGLLWIATLGQGLFIYDPKTEVLT-----QNSIQTSFVWDVCQSYDKKKVYVSSLQEG 190
Query: 439 LNLLD-----LKAPRQILEVISSQTGGGFPINFIGVLNYDPINEGIWIGANQGLYFYDPV 493
L D L++ R +V SS + + IN + + +W+GA L +
Sbjct: 191 LLCFDENGKFLQSYRVSSDVNSSDS---YKINCV-----LDVEGEVWLGAGNNL--LGRL 240
Query: 494 KKEITAPLPDKAAENIH-GCIGSIID-KEGKLWVGCLEGVYIIDLHSRSSKGEFQYRHLN 551
++ T + + A +++ G + S++ E +L VG G+Y L +R SK + +
Sbjct: 241 NRQ-TGTVENYMAPSLNFGAVRSLLKYTENELLVGTDNGLY---LFNRESKTFLRADN-- 294
Query: 552 YKLDDPSSRLIEKITCFYQGKDGTLWLGSNGYGI-YQRKIDAQGKEQFISYSTAQGLPNN 610
DP S + I +G LW+ +N GI Y K + +Y +
Sbjct: 295 --PADPRSLSDQTINGMMWDAEGALWVLTNLGGINYMSKQTKRFDYYSPAYLSGIAGAGE 352
Query: 611 SVRGILEDNNGNLWISTNNGLSCYHQAENRFINYTIQDGLIDTQFYWNASCGSSHDLLYF 670
V E+ +GN+WI T +GL ++ Y I G + +Q Y S D L+
Sbjct: 353 VVGPFCENKDGNIWIGTQSGLYFFNTVTRELSEYHI--GGVKSQKYDIRSLMLDGDCLWI 410
Query: 671 GS 672
G+
Sbjct: 411 GT 412
Score = 34.7 bits (78), Expect = 7e-05
Identities = 15/51 (29%), Positives = 27/51 (52%)
Query: 598 FISYSTAQGLPNNSVRGILEDNNGNLWISTNNGLSCYHQAENRFINYTIQD 648
F Y GL +N+V ++D+ G +W+ T++GL+ Y N+ + D
Sbjct: 26 FKKYQVEDGLSHNTVWCAIQDSYGFIWLGTSDGLNRYDGRGNKVYRNVLND 76