Pairwise Alignments
Query, 1420 a.a., two-component system sensor histidine kinase/response regulator, hybrid ('one component system') (NCBI ptt file) from Bacteroides thetaiotaomicron VPI-5482
Subject, 1271 a.a., two-component system sensor histidine kinase/response regulator, hybrid ('one-component system') (NCBI ptt file) from Bacteroides thetaiotaomicron VPI-5482
Score = 437 bits (1123), Expect = e-126
Identities = 356/1290 (27%), Positives = 603/1290 (46%), Gaps = 128/1290 (9%)
Query: 142 IMKDTQGCIW-LHCDNALHRIEFNDKGEVQILSTLSPVYLNGPDIALKDIDEDGKIWMGN 200
I+ D+ IW L D L R + G+V S + L + I+E G++W+G
Sbjct: 62 ILSDSLDNIWVLIPDQGLFRYK---DGKVHHYSLIDKDNLKNNNPECICINEQGEVWVGT 118
Query: 201 NGEIRKVALSPQKRLVTTPIADCL--KFEAGTYISDFLSKENEVWISSDRGLFRYNKTGN 258
+G I + + + D + T IS KEN + + L +YN +
Sbjct: 119 SG-IGLFKYNYRDDNFEQYLTDRMGRSLIDKTIISICFQKENAILGIHEGDLLKYNTRTD 177
Query: 259 VIKRYEHDSGNPYSLSQNYLTNLAITDDKQLIVATLRGINIYNPMTDNFERIACDLPNGG 318
+ + +L ++ D ++ V +L GI I N +N + DL
Sbjct: 178 ELSEVSF-----LGEKKTFLRDVMCFGD-EIWVGSLHGIFIINEKENNVIHLKEDLMRSF 231
Query: 319 TNLLNSNFINCILTDGEH-IWFGTETGGINLLNPRQLSIRSYRHDKENPSSLSYNPVNAI 377
+ L+ N I I D E IW GT GG+N L R L+ Y ++ SL+ + +
Sbjct: 232 S--LSDNSIYSIYKDYEGGIWIGTMFGGVNYLPNRILTFAKYVPGSDS-YSLNTKRIRGL 288
Query: 378 YEDVYGTLWVGTVEGGLNRKE-RNSEDFTHYTREHGGLSHNSVSALTADTDNHLWIGTWG 436
ED G +W+GT + G+N + R + Y G L SV +NH+++G +
Sbjct: 289 AEDNNGCIWIGTEDNGVNVLDPRTGKVHQIYDNVPGRLITLSVKHY----ENHIYVGLFK 344
Query: 437 GGLNLLDLKAPRQILEVISSQTGGGFPINFIGVLNYDPINEG-IWIGANQGLYFYDPVKK 495
G+N D+ P + L+ +S + G I V ++ ++G WIG GLY P ++
Sbjct: 345 QGMN--DISIPGEHLKYVSDKDLG---IEEGSVYSFLKDSKGRTWIGPGWGLYVSQPKER 399
Query: 496 EITAPLPDKAAENIHGCIGSIID-KEGKLWVGCL-EGVYIIDLHSRSSKGEFQYRHLNYK 553
+ + E + + I++ ++G +W+ + GV+ D + S Y++ +YK
Sbjct: 400 KF-----HRVEEVGYNWVFDIMEARDGTIWLATMGNGVWKCDPKNNS------YKNYSYK 448
Query: 554 LDDPSSRLIEKITCFYQGKDGTLWLGSNGYGIYQRKIDAQGKEQFISYSTAQGLPNNSVR 613
+S ++ Q G +W ++ GI + + ++ F ++S GLP++
Sbjct: 449 EGVDNSLSSNSVSSIMQDSKGNIWFSTDRGGICRYN---EAQDNFTTFSIEDGLPDDVAY 505
Query: 614 GILEDNNGNLWISTNNGLSCYHQAENRFINYTIQDGLIDTQFYWNASCGSSHDLLYFGSV 673
ILED+ GNLW TN GL ++ +T +DGL+ QF + ++ + YFG V
Sbjct: 506 NILEDDAGNLWFGTNKGLVKFNPESGDVRVFTNKDGLLGNQFNYQSALKAQDGRFYFGGV 565
Query: 674 GGLVAIESNRPAMSLPAAKVRFTRLRIGNEEIL---PGSEYLSEDIAITTELKLHEKEKS 730
GL+A + P V ++ I N+E+ P S L + I T E+ L + +
Sbjct: 566 DGLIAFDPTVQEEEKPLPPVYISKFSIYNKEVTVHTPESP-LKQCIVHTDEIVLPYDQAN 624
Query: 731 FSLEFAALNFESNNTAIYSYRLVGFDDKWVQVPGNRRFASYTNLPPGSYTLQVRYTPDGE 790
S + A L++ + + Y YR+ D WV+ N+ SY LPPG YT +V+ T +
Sbjct: 625 ISFDVALLSYSTAESNQYYYRMEPLDRDWVRAASNQNI-SYAKLPPGKYTFRVQATHGSK 683
Query: 791 NEGENITELKITIVPYFYKTVWFILFIIVLLSVSVWQFYQWRIRNLKRQKEYLHRTVEER 850
+E + I + P++ + +I++ + ++ + V ++ R K+ +E ++
Sbjct: 684 SESSTRSLSIIILPPWWQSIIAYIVYTVCIILIVVGTILWYKRRKEKQLEE------RQK 737
Query: 851 THELEQQKHLLENQTDELSRQNQMLIQQNEKITRQKAQLIRMSRKVQELTLDKISFFTNI 910
E+E++K L E+ K+ FFT I
Sbjct: 738 LFEIEKEKELYES---------------------------------------KVDFFTEI 758
Query: 911 THEFRTPITLIIGPIERALKLSYN-PQVIEQLNFVERNSKYLLSLVNQLMDFRKVESGKL 969
HE RTP+TLI GP+E ++ P++ + ++ + +N+K LL L QL+DF+K+ + KL
Sbjct: 759 AHEVRTPLTLINGPLEAIEEMEIQEPKMKKYISVMVQNTKRLLELTGQLLDFQKIGANKL 818
Query: 970 EIVKTRGNFLKFIDSLITPFEVFAQERNIVLKRYYRMEMPEILYDEEAMRKVVTNLLSNA 1029
+ + + + ++ FEV L+ E D+EA+ K+++NLL+NA
Sbjct: 819 TMKFESVDITELLAGIVARFEVTFSLNRKELQLKSTDEQVWAAVDKEAITKILSNLLNNA 878
Query: 1030 IKFTPNGGTVSLYLSALFAKDSEKETLYICVKDSGSGIPEEDLNRIFNRFYQSQNQVKYP 1089
+K+ V L + +++ I V G+ IP E IF FYQ + K
Sbjct: 879 LKYASQNVLVEL--------EKGEDSFTIRVTSDGNKIPAEVSQYIFEPFYQVDRKEK-- 928
Query: 1090 VYGQAGTGIGLYLCKRIVQMHGGEIKAFNNRHAGCSFRILLPL------QRNERKDEKTI 1143
+ G GIGL L + + +H G I + R F + +PL Q N + +K I
Sbjct: 929 --PRNGVGIGLSLARSLASLHKGTIY-LDTRQENNMFVLTIPLNMEGIKQENNKAIQKDI 985
Query: 1144 I-IDHNDSSATPVQDSGSPKEKEALSILVVEDNADMRGYIRSILREQYHVLEAANGEEAL 1202
+ +D + TPV + ++L+VEDN M +I L+E + V A NG EAL
Sbjct: 986 VELDEH----TPVT-----ADMYGYTLLLVEDNESMLTFILERLQENFTVETAMNGVEAL 1036
Query: 1203 HILNSNPIDFIISDLMMPVMDGIELSRRVKETFAISHIPFLMLTAKTSQEARLESYRMGV 1262
IL S+ ID IISD+MMPVMDG +L + VK +SHIP + LTAK ++++ + G
Sbjct: 1037 EILRSSHIDLIISDIMMPVMDGYQLCKEVKSDMELSHIPIIFLTAKNDIDSKINGLKYGA 1096
Query: 1263 DEYLLKPFDETLLLARIQNILENRKRYQRKFTLDMDVDVLNMEEESGDKKFLNQVMEVIK 1322
+ Y+ KPF L ++ ++L+NR+R + F V NM+ D++F+N+V++VI+
Sbjct: 1097 EAYVEKPFSFNYLKEQVLSLLDNRRREREAFAKRPFFSVNNMQMNKADEEFMNKVIKVIE 1156
Query: 1323 ENYKNSYFEVSDFCEAVGVSKSLLNKKLQNLIGQSAGQFIRNYRLNIARELILKNRETKN 1382
+N + F V + + +S+S L +K++ L S FIR +L A E I + +
Sbjct: 1157 DNITDDNFGVERMADILCMSRSSLLRKIKTLFNLSPLDFIRLIKLKKAAEFIQEGK---- 1212
Query: 1383 MNIAEVAYEVGFNDPKYFTRCFTKHFNVTP 1412
I ++ Y VG N P YF++ F K F +TP
Sbjct: 1213 YRIGDICYMVGINSPSYFSKLFLKQFGMTP 1242
Score = 62.8 bits (151), Expect = 2e-13
Identities = 83/369 (22%), Positives = 151/369 (40%), Gaps = 52/369 (14%)
Query: 42 LPHNFIDDLYKDSRGFMWISTAGGGLSRYDG--YEFVNYTPNNHQCKLKSNFIRNVCEDA 99
L N I +YKD G +WI T GG++ F Y P + L + IR + ED
Sbjct: 233 LSDNSIYSIYKDYEGGIWIGTMFGGVNYLPNRILTFAKYVPGSDSYSLNTKRIRGLAEDN 292
Query: 100 FQRLWIVSE-GGTDIIDLSTLKPIIPHDPKGILPKILELPATRIMKDTQGCIWLHCDNAL 158
+WI +E G +++D T K +D +P I + H +N +
Sbjct: 293 NGCIWIGTEDNGVNVLDPRTGKVHQIYD---------NVPGRLITLSVK-----HYENHI 338
Query: 159 HRIEFNDKGEVQILSTLSPVYLNGPDIALKD-------IDEDGKIWMGNNGEIRKVALSP 211
+ F + Y++ D+ +++ D G+ W+G + P
Sbjct: 339 YVGLFKQGMNDISIPGEHLKYVSDKDLGIEEGSVYSFLKDSKGRTWIGPGWGL--YVSQP 396
Query: 212 QKRLVTTPIADCLKF----EAG-TYISDFL-SKENEVWISS-DRGLFRYNKTGNVIKRYE 264
++R KF E G ++ D + +++ +W+++ G+++ + N K Y
Sbjct: 397 KER----------KFHRVEEVGYNWVFDIMEARDGTIWLATMGNGVWKCDPKNNSYKNYS 446
Query: 265 HDSGNPYSLSQNYLTNLAITDDKQLIVATLR-GINIYNPMTDNFERIACDLPNGGTNLLN 323
+ G SLS N ++++ + +T R GI YN DNF + + L +
Sbjct: 447 YKEGVDNSLSSNSVSSIMQDSKGNIWFSTDRGGICRYNEAQDNFTTFSIE-----DGLPD 501
Query: 324 SNFINCILTDGEHIWFGTETGGINLLNPRQLSIRSYRHDKENPSSLSYNPVNAIYEDVYG 383
N + D ++WFGT G + NP +R + +K+ +N +A+ + G
Sbjct: 502 DVAYNILEDDAGNLWFGTNKGLVK-FNPESGDVRVFT-NKDGLLGNQFNYQSAL-KAQDG 558
Query: 384 TLWVGTVEG 392
+ G V+G
Sbjct: 559 RFYFGGVDG 567
Score = 57.0 bits (136), Expect = 1e-11
Identities = 81/343 (23%), Positives = 131/343 (38%), Gaps = 75/343 (21%)
Query: 297 INIYNPMTDNFERIACDLPNGGTNLLNSNFINCILTDG-EHIWFGTETGGINLLNPRQLS 355
+NIYNP D F+R G T N++ IL+D ++IW G L +
Sbjct: 32 VNIYNPAVDVFKRFKIASSEGITL---DNWVAEILSDSLDNIWVLIPDQG--LFRYKDGK 86
Query: 356 IRSYRH-DKENPSSLSYNPVNAIYEDVYGTLWVGTVEGGLNRKERNSEDFTHYTREHGGL 414
+ Y DK+N L N I + G +WVGT GL + ++F Y + G
Sbjct: 87 VHHYSLIDKDN---LKNNNPECICINEQGEVWVGTSGIGLFKYNYRDDNFEQYLTDRMGR 143
Query: 415 SHNSVSALTADTDNHLWIGTWGGGLNLLDLKAPRQILEVISSQTGGGFPINFIGVLNY-- 472
S L+D + I+ + + I+ +L Y
Sbjct: 144 S-------------------------LID----KTIISICFQKENAILGIHEGDLLKYNT 174
Query: 473 --DPINEGIWIGANQGLYFYDPVKKEITAPLPDKAAENIHGCIGSIIDKEGKLWVGCLEG 530
D ++E ++G + + D + C G I WVG L G
Sbjct: 175 RTDELSEVSFLGEKK-TFLRDVM------------------CFGDEI------WVGSLHG 209
Query: 531 VYIIDLHSRSSKGEFQYRHLNYKLDDPSSRLIEKITCFYQGKDGTLWLGSNGYGIYQRKI 590
++II ++ E HL L S I Y+ +G +W+G+ G+
Sbjct: 210 IFII------NEKENNVIHLKEDLMRSFSLSDNSIYSIYKDYEGGIWIGTMFGGVNYLPN 263
Query: 591 DAQGKEQFISYSTAQGLPNNSVRGILEDNNGNLWIST-NNGLS 632
+++ S + L +RG+ EDNNG +WI T +NG++
Sbjct: 264 RILTFAKYVPGSDSYSLNTKRIRGLAEDNNGCIWIGTEDNGVN 306
Score = 38.9 bits (89), Expect = 3e-06
Identities = 21/73 (28%), Positives = 37/73 (50%), Gaps = 1/73 (1%)
Query: 38 MNEGLPHNFIDDLYKDSRGFMWISTAGGGLSRYDGYEFVNYTPNNHQCKLKSNFIRNVCE 97
++ L N + + +DS+G +W ST GG+ RY+ + N+T + + L + N+ E
Sbjct: 451 VDNSLSSNSVSSIMQDSKGNIWFSTDRGGICRYNEAQ-DNFTTFSIEDGLPDDVAYNILE 509
Query: 98 DAFQRLWIVSEGG 110
D LW + G
Sbjct: 510 DDAGNLWFGTNKG 522
Score = 38.1 bits (87), Expect = 6e-06
Identities = 44/217 (20%), Positives = 89/217 (41%), Gaps = 34/217 (15%)
Query: 40 EGLPHNFIDDLYKDSRGFMWISTAGGGLSRYD--GYEFVNYT-PNNHQCKLKSNFIRNVC 96
E + +N++ D+ + G +W++T G G+ + D + NY+ L SN + ++
Sbjct: 405 EEVGYNWVFDIMEARDGTIWLATMGNGVWKCDPKNNSYKNYSYKEGVDNSLSSNSVSSIM 464
Query: 97 EDAFQRLWIVSEGG--------TDIIDLSTLKPIIPHDPKGILPKILELPATRIMKDTQG 148
+D+ +W ++ G D +++ +P D A I++D G
Sbjct: 465 QDSKGNIWFSTDRGGICRYNEAQDNFTTFSIEDGLPDD-----------VAYNILEDDAG 513
Query: 149 CIWLHCDNALHRIEFN-DKGEVQILSTLSPVYLNGPDIALKDIDEDGKIWMGNNGEIRKV 207
+W + L ++FN + G+V++ + + N + +DG+ + G G +
Sbjct: 514 NLWFGTNKGL--VKFNPESGDVRVFTNKDGLLGNQFNYQSALKAQDGRFYFG--GVDGLI 569
Query: 208 ALSPQKRLVTTPIADCLKFEAGTYISDFLSKENEVWI 244
A P + P+ YIS F EV +
Sbjct: 570 AFDPTVQEEEKPLPP-------VYISKFSIYNKEVTV 599
Score = 27.3 bits (59), Expect = 0.010
Identities = 53/237 (22%), Positives = 88/237 (37%), Gaps = 30/237 (12%)
Query: 32 NITYVTMNE-GLPHNFIDDLYKDSRGFMWISTAGGGL-------SRYDGYEFVNYTPNNH 83
++ YV+ + G+ + KDS+G WI G GL ++ E V Y
Sbjct: 356 HLKYVSDKDLGIEEGSVYSFLKDSKGRTWIG-PGWGLYVSQPKERKFHRVEEVGY----- 409
Query: 84 QCKLKSNFIRNVCEDAFQRLWIVSEG-GTDIIDLSTLKPIIPHDPKGILPKILELPATRI 142
N++ ++ E +W+ + G G D +G+ + + I
Sbjct: 410 ------NWVFDIMEARDGTIWLATMGNGVWKCDPKNNSYKNYSYKEGVDNSLSSNSVSSI 463
Query: 143 MKDTQGCIWLHCDNALHRIEFNDKGEVQILSTLSPVYLNGPDIALKDIDED--GKIWMG- 199
M+D++G IW D R E Q T + PD +I ED G +W G
Sbjct: 464 MQDSKGNIWFSTD----RGGICRYNEAQDNFTTFSIEDGLPDDVAYNILEDDAGNLWFGT 519
Query: 200 NNGEIRKVALSPQKRLVTTPIADCLKFEAGTYISDFLSKENEVWISSDRGLFRYNKT 256
N G ++ S R+ T D L Y S +++ + GL ++ T
Sbjct: 520 NKGLVKFNPESGDVRVFTN--KDGLLGNQFNYQSALKAQDGRFYFGGVDGLIAFDPT 574