Pairwise Alignments
Query, 1420 a.a., two-component system sensor histidine kinase/response regulator, hybrid ('one component system') (NCBI ptt file) from Bacteroides thetaiotaomicron VPI-5482
Subject, 1472 a.a., two-component system sensor histidine kinase/response regulator, hybrid ('one component system') (NCBI ptt file) from Bacteroides thetaiotaomicron VPI-5482
Score = 444 bits (1143), Expect = e-128
Identities = 315/1073 (29%), Positives = 521/1073 (48%), Gaps = 141/1073 (13%)
Query: 377 IYEDVYGTLWVGTVEGGLNRKERNSED-----FTHYTREH---GGLSHNSVSALTADTDN 428
I ED G LW T GL + E + FT Y + +S+N V D+
Sbjct: 504 IMEDKEGNLWFSTKGNGLVKAEPDMNSPHGLRFTRYKNDPKNPNSISNNDVYFTYQDSQE 563
Query: 429 HLWIGTWGGGLNLLDLKAPRQILEVISSQTGG-GFPINFIGVLNYDPINEGIWIGANQGL 487
+W+G GGGLNL IS + G F + G+ Y GL
Sbjct: 564 RIWVGLLGGGLNL------------ISEENGTLVFKHKYNGLKQYPAY----------GL 601
Query: 488 YFYDPVKKEITAPLPDKAAENIHGCIGSIIDKEGKLWVGCLEGVYIIDLHSRSSKGEFQY 547
Y E D++G++WVG ++G+ D H + + Q
Sbjct: 602 YMEVRTMTE---------------------DEDGRIWVGTMDGLMSFDGHFTTPE---QI 637
Query: 548 RHLNYK-LDDPSSRLIEKITCFYQGKDGTLWLGSNGYGIYQR-KIDAQGKEQ-FISYSTA 604
+ Y+ + D S+ I Y+ D +W+ G G+ + + D + +E F SY
Sbjct: 638 QFETYRQISDRSNVADNDIYVLYKDSDSQIWVSVFGGGLNKLVRYDKEKREPIFKSYGIR 697
Query: 605 QGLPNNSVRGILEDNNGNLWISTNNGLSCYHQAENRFINYTIQDGLIDTQFYWNASCGSS 664
+G+ N+ V+ I+ED NGNLW +T GLSC+++A +F NY DG ++ + ++ +
Sbjct: 698 EGMNNDVVKSIVEDKNGNLWFTTEIGLSCFNKATEQFRNYDKYDGFLNVELEEGSALRAL 757
Query: 665 HDLLYFGSVGGLVAIESNRPAMSLPAAKVRFTRLRIGNEEILPGSEY-LSEDIAITTELK 723
+ L+ GS G++ ++ R ++ N + ++ + E I T L+
Sbjct: 758 NGDLWLGSRQGILTFSPDKLETQHTNYDTRIVDFKVSNRNLRSLNDCPIQESITYTDALQ 817
Query: 724 LHEKEKSFSLEFAALNFESNNTAIYSYRLVGFDDKWVQVPGNRRFASYTNLPPGSYTLQV 783
L + F++EFAALNF + N Y Y L G++ +W G R ASYTN+PPG Y +V
Sbjct: 818 LKYNQSMFTIEFAALNFYNQNRVSYRYILEGYEKEW-HYNGKNRIASYTNVPPGDYVFRV 876
Query: 784 RYTPDGENEGENITELKITIVPYFYKTVWFILFIIVLLSVSVWQFYQWRIRNLKRQKEYL 843
+ E + L +TI+P ++ + W+ I V+L ++ F
Sbjct: 877 ETMDEANPELVSTCTLAVTILPPWWLS-WWATLIYVILGIAALYFG-------------- 921
Query: 844 HRTVEERTHELEQQKHLLENQTDELSRQNQMLIQQNEKITRQKAQLIRMSRKVQELTLDK 903
L + +N + I+Q KV E+ K
Sbjct: 922 -----------------LRLAFFMIKMKNDIYIEQ----------------KVSEM---K 945
Query: 904 ISFFTNITHEFRTPITLIIGPIERALKLS-YNPQVIEQLNFVERNSKYLLSLVNQLMDFR 962
I FFTNI+HE RTP+TLI GPI+ + +P+ ++ ++ +E+N+ +L LVNQ++DFR
Sbjct: 946 IKFFTNISHELRTPLTLIKGPIQELKEREELSPKGLQYVDLMEKNTNQMLQLVNQILDFR 1005
Query: 963 KVESGKLEIVKTRGNFLKFIDSLITPFEVFAQERNIVLKRYYRMEMPEILYDEEAMRKVV 1022
K+++GK+ + + +F + I S F V ++E I E + D++ + V+
Sbjct: 1006 KIQNGKMRLHVSLIDFNEMIASFQKEFRVLSEENEISFTFQLPDEPIMVWADKDKLSIVI 1065
Query: 1023 TNLLSNAIKFTPNGGTVSLYLSALFAKDSEKETLYICVKDSGSGIPEEDLNRIFNRFYQS 1082
N++SNA KFTP+GG S+Y++ D + + Y+ V+D+G GIP+ L+ IF RF Q
Sbjct: 1066 RNVISNAFKFTPSGG--SIYVTTGLTDDGK--SCYVRVEDNGVGIPQNKLSEIFERFSQG 1121
Query: 1083 QNQVKYPVYGQAGTGIGLYLCKRIVQMHGGEIKAFNNRHAGCSFRILLPLQRNERKDEKT 1142
+N P Y GTGIGL L K IV +H G I+A + G F + L L ++ + +
Sbjct: 1122 EN-ANNPHY--QGTGIGLALSKEIVNLHHGIIRAESPEGQGAVFIVELLLDKDHYRPSEV 1178
Query: 1143 IIIDHNDSSATPVQDS----GSPKEKEAL--------SILVVEDNADMRGYIRSILREQY 1190
+ +A D S KE E ++L+VEDN D+ I+ L +++
Sbjct: 1179 DFYVSDTETAPAATDKKMVIDSEKEPEEELEIDASLPTLLLVEDNKDLCQLIKLQLEDKF 1238
Query: 1191 HVLEAANGEEALHILNSNPIDFIISDLMMPVMDGIELSRRVKETFAISHIPFLMLTAKTS 1250
++ A NG E L ++ D +++D MMP MDG+E+ + +++ F ISHIP ++LTAK
Sbjct: 1239 NIHIANNGVEGLKKVHLYHPDIVVTDQMMPEMDGLEMLQSIRKDFQISHIPVIILTAKND 1298
Query: 1251 QEARLESYRMGVDEYLLKPFDETLLLARIQNILENRKRYQRKFTLDMDVDVLNMEEE--- 1307
+ A+ ++ +G + Y+ KPF + LLARI +L RK ++ + M+ E+
Sbjct: 1299 EGAKTKAITLGANAYITKPFSKEYLLARIDQLLGERKLFRERIRQQMENQTTTEEDSYEQ 1358
Query: 1308 ---SGDKKFLNQVMEVIKENYKNSYFEVSDFCEAVGVSKSLLNKKLQNLIGQSAGQFIRN 1364
D +FL ++ +VI+EN +S F + +G+S+S KKL++L G + ++
Sbjct: 1359 YLVKKDVQFLEKIHQVIEENMDDSDFNIDTIASGIGLSRSAFFKKLKSLTGLAPVDLVKE 1418
Query: 1365 YRLNIARELILKNRETKNMNIAEVAYEVGFNDPKYFTRCFTKHFNVTPSALLN 1417
RLN + ELI + +++++EVA+ VGF D Y+++CF K +N TP +N
Sbjct: 1419 IRLNKSIELI----KNTDLSVSEVAFAVGFKDSGYYSKCFRKKYNQTPREYMN 1467
Score = 74.3 bits (181), Expect = 8e-17
Identities = 120/535 (22%), Positives = 212/535 (39%), Gaps = 114/535 (21%)
Query: 28 ADRYNITYVTMNEGLPHNF----IDDLYKDSRGFMWISTAGGGLSRYDGYEFVNYTPNNH 83
A YNI Y + + LP + + ++ D +W L+ YD +NH
Sbjct: 292 AYEYNIGYKQLTK-LPFSIAGKKVGMIFNDKYDKIWFQEGNEALTYYDPLN-----KSNH 345
Query: 84 QCKL-KSNFIRNV-CEDAFQR-LWIVSEGGTDII-DLSTLKPIIPHDPKGILPKILELPA 139
+ K N I N +DA ++ ++ ++ GG ++ D L+ + K + +
Sbjct: 346 RFPFPKQNAIGNFEKQDAGEQGMFFLTPGGEILLFDREKLEMTRINQLKPFSDDLPDQLF 405
Query: 140 TRIMKDTQGCIWL-HCDNALHRIEFNDKGEVQILSTLSPVYLN-------GPDIALKDID 191
++ D G +WL + ++++ F K + Q+L+ +SPV ++ I
Sbjct: 406 FHLLLDKDGILWLASTGSGVYKVNFPKK-QFQLLTEVSPVPVDTERATSWNQGIRALYQA 464
Query: 192 EDGKIWMG----------NNGEIRKVALSPQKRLVTTPIADCLKFEAGTYISDFLSKENE 241
++G IW+G +NG+I++V + Q L+ G KE
Sbjct: 465 KNGDIWVGTRWQALYRLDSNGQIKQV-FTDQNYLI------------GAVYHIMEDKEGN 511
Query: 242 VWISSD-RGLFRYNKTGNV-----IKRYEHDSGNPYSLSQNYLTNLAITDDKQLIVATLR 295
+W S+ GL + N RY++D NP S+S N
Sbjct: 512 LWFSTKGNGLVKAEPDMNSPHGLRFTRYKNDPKNPNSISNN------------------- 552
Query: 296 GINIYNPMTDNFERIACDLPNGGTNLLNSNFINCI----------------------LTD 333
++Y D+ ERI L GG NL++ + +T+
Sbjct: 553 --DVYFTYQDSQERIWVGLLGGGLNLISEENGTLVFKHKYNGLKQYPAYGLYMEVRTMTE 610
Query: 334 GE--HIWFGTETGGINL----LNPRQLSIRSYRHDKENPSSLSYNPVNAIYEDVYGTLWV 387
E IW GT G ++ P Q+ +YR + S+++ N + +Y+D +WV
Sbjct: 611 DEDGRIWVGTMDGLMSFDGHFTTPEQIQFETYRQISDR-SNVADNDIYVLYKDSDSQIWV 669
Query: 388 GTVEGGLNR-----KERNSEDFTHY-TREHGGLSHNSVSALTADTDNHLWIGTWGGGLNL 441
GGLN+ KE+ F Y RE G++++ V ++ D + +LW T GL+
Sbjct: 670 SVFGGGLNKLVRYDKEKREPIFKSYGIRE--GMNNDVVKSIVEDKNGNLWFTT-EIGLSC 726
Query: 442 LDLKAPRQILEVISSQTGGGFPINFIGVLNYDPINEGIWIGANQGLYFYDPVKKE 496
+ KA Q + G + +N +W+G+ QG+ + P K E
Sbjct: 727 FN-KATEQFRNY--DKYDGFLNVELEEGSALRALNGDLWLGSRQGILTFSPDKLE 778
Score = 70.9 bits (172), Expect = 9e-16
Identities = 75/275 (27%), Positives = 118/275 (42%), Gaps = 37/275 (13%)
Query: 330 ILTDGE-HIWFGTETGGI-----NLLNPRQLSIRSYRHDKENPSSLSYNPVNAIYEDVYG 383
I+ D E ++WF T+ G+ ++ +P L Y++D +NP+S+S N V Y+D
Sbjct: 504 IMEDKEGNLWFSTKGNGLVKAEPDMNSPHGLRFTRYKNDPKNPNSISNNDVYFTYQDSQE 563
Query: 384 TLWVGTVEGGLN--RKERNSEDFTHYTREHGGLS-------HNSVSALTADTDNHLWIGT 434
+WVG + GGLN +E + F H ++ GL + V +T D D +W+GT
Sbjct: 564 RIWVGLLGGGLNLISEENGTLVFKH---KYNGLKQYPAYGLYMEVRTMTEDEDGRIWVGT 620
Query: 435 WGGGLNL-LDLKAPRQILEVISSQTGGGFPI--NFIGVLNYDPINEGIWI----GANQGL 487
G ++ P QI Q + N I VL Y + IW+ G L
Sbjct: 621 MDGLMSFDGHFTTPEQIQFETYRQISDRSNVADNDIYVL-YKDSDSQIWVSVFGGGLNKL 679
Query: 488 YFYDPVKKE-ITAPLPDKAAENIHGCIGSIIDKEGKLWVGCLEGVYIIDLHSRSSKGEFQ 546
YD K+E I + N + DK G LW G+ + + + +
Sbjct: 680 VRYDKEKREPIFKSYGIREGMNNDVVKSIVEDKNGNLWFTTEIGLSCFNKATEQFRNYDK 739
Query: 547 Y-RHLNYKLDDPSSRLIEKITCFYQGKDGTLWLGS 580
Y LN +L++ S+ + +G LWLGS
Sbjct: 740 YDGFLNVELEEGSA---------LRALNGDLWLGS 765
Score = 70.1 bits (170), Expect = 2e-15
Identities = 144/687 (20%), Positives = 261/687 (37%), Gaps = 113/687 (16%)
Query: 1 MKKH---LLIYLIIYSICSLAGQVRAQERFADRYNITYVTMNEGLPHNFIDDLYKDSRGF 57
MKKH + ++L++ IC+ A E + T GLP+N ++ K GF
Sbjct: 1 MKKHFFFIFMFLLMTRICAFAYPNMIVEHY---------TAERGLPNNIVNCTLKGQDGF 51
Query: 58 MWISTAGGGLSRYDGYEFVNYTPNN--HQCKLKSNFIRNVCEDAFQRLWIVSEGGTDIID 115
+W T GL +DG +F +Y ++ + + I+ + ED LWI + ID
Sbjct: 52 VWFGT-WYGLCSFDGTKFRSYDNHDGFYSADIPPRKIQRIVEDRNGYLWIKT------ID 104
Query: 116 LSTLKPIIPHDP-KGILPKILELPAT-RIMK----DTQGCIWLHCDNALHRIEFNDKGEV 169
H+ + + E +I+K D + L D +L R + G++
Sbjct: 105 RKLYLFDKKHESFHAVYDDVKEYSENIQIIKIQTTDDGDVLLLTKDKSLLRANTDQNGKI 164
Query: 170 QILSTLSPVYLNGPDIALKDIDEDGKI---------WMGNNGEIRKVALSPQKRLVTTPI 220
T+ ++ + P++ + D+ + W+G + +I ++L + L P+
Sbjct: 165 ----TMKQLHDSRPNVNVYDLRLKHNVFCETAEFINWIGMDYQI--LSLRKGEALKDKPV 218
Query: 221 --------ADCLKFEAGTYISDFLSKENEVWISSDRG-LFRYNKTGNVIKRYEHDSGNPY 271
A+ +F +Y S FL W+ G ++ + V+ RYE
Sbjct: 219 DFIQKKVSANPDQFTCASYSSKFL------WLGDKNGHIYSVDPQNGVVNRYEIPE---- 268
Query: 272 SLSQNYLTNLAITDDKQLIVATLRGINIYNPMTDNFERIACDLPNGGTNLL-NSNFINCI 330
++N+ +T+ + + T+ G YN ++ + ++ N +
Sbjct: 269 --IDQPISNILVTESGLMYITTVDGAYEYNIGYKQLTKLPFSIAGKKVGMIFNDKY---- 322
Query: 331 LTDGEHIWFGTETGGINLLNPRQLSIRSYRHDKENPSSLSYNPVNAIYEDVYGTLWVGTV 390
+ IWF + +P S + K+N ++ +A + ++ T
Sbjct: 323 ----DKIWFQEGNEALTYYDPLNKSNHRFPFPKQNAIG-NFEKQDAGEQGMFFL----TP 373
Query: 391 EGGLNRKERNSEDFTHYTREH---GGLSHNSVSALTADTDNHLWIGTWGGGLNLLDL-KA 446
G + +R + T + L L D D LW+ + G G+ ++ K
Sbjct: 374 GGEILLFDREKLEMTRINQLKPFSDDLPDQLFFHLLLDKDGILWLASTGSGVYKVNFPKK 433
Query: 447 PRQILEVISS---QTGGGFPINFIGVLNYDPINEGIWIGAN-QGLYFYDPVKKEITAPLP 502
Q+L +S T N Y N IW+G Q LY D +I
Sbjct: 434 QFQLLTEVSPVPVDTERATSWNQGIRALYQAKNGDIWVGTRWQALYRLDS-NGQIKQVFT 492
Query: 503 DKAAENIHGCIGSII-DKEGKLWVGCL-EGVYIIDLHSRSSKGEFQYRHLNYKLD--DPS 558
D+ + G + I+ DKEG LW G+ + S G R YK D +P+
Sbjct: 493 DQ--NYLIGAVYHIMEDKEGNLWFSTKGNGLVKAEPDMNSPHG---LRFTRYKNDPKNPN 547
Query: 559 SRLIEKITCFYQGKDGTLWLG-----------SNGYGIYQRKIDAQGKEQFISYSTAQGL 607
S + YQ +W+G NG +++ K + G +Q+ +Y
Sbjct: 548 SISNNDVYFTYQDSQERIWVGLLGGGLNLISEENGTLVFKHKYN--GLKQYPAYGLYM-- 603
Query: 608 PNNSVRGILEDNNGNLWISTNNGLSCY 634
VR + ED +G +W+ T +GL +
Sbjct: 604 ---EVRTMTEDEDGRIWVGTMDGLMSF 627
Score = 37.7 bits (86), Expect = 9e-06
Identities = 26/103 (25%), Positives = 47/103 (45%), Gaps = 13/103 (12%)
Query: 20 QVRAQERFADRYNITYVTMNEGLPHNFIDDLYKDSRGFMWISTAGGGLSRYDGYEFVNYT 79
Q + +DR N+ N I LYKDS +W+S GGGL++ Y+
Sbjct: 638 QFETYRQISDRSNVA---------DNDIYVLYKDSDSQIWVSVFGGGLNKLVRYDKEKRE 688
Query: 80 P--NNHQCK--LKSNFIRNVCEDAFQRLWIVSEGGTDIIDLST 118
P ++ + + ++ ++++ ED LW +E G + +T
Sbjct: 689 PIFKSYGIREGMNNDVVKSIVEDKNGNLWFTTEIGLSCFNKAT 731
Score = 31.6 bits (70), Expect = 6e-04
Identities = 17/49 (34%), Positives = 25/49 (51%), Gaps = 2/49 (4%)
Query: 601 YSTAQGLPNNSVRGILEDNNGNLWISTNNGLSCYHQAENRFINYTIQDG 649
Y+ +GLPNN V L+ +G +W T GL + +F +Y DG
Sbjct: 30 YTAERGLPNNIVNCTLKGQDGFVWFGTWYGLCSFD--GTKFRSYDNHDG 76