Pairwise Alignments

Query, 884 a.a., DNA topoisomerase 1 from Alteromonas macleodii MIT1002

Subject, 823 a.a., DNA topoisomerase I from Methanococcus maripaludis S2

 Score =  239 bits (610), Expect = 5e-67
 Identities = 231/806 (28%), Positives = 371/806 (46%), Gaps = 92/806 (11%)

Query: 5   LVIVESPAKAKTINKYLGKNFIVKSSVGHVRDLPTKALGK-VEPKKPAKELKTLSEEERQ 63
           L+I E P  AK I + LGK    K S   V     +  G+ +        L TL E+ + 
Sbjct: 4   LIICEKPNVAKKIAEALGKP--KKKSHNSVPYYELERNGESIVVASAVGHLYTLQEKTKT 61

Query: 64  EYLRRHEY-LKLVDRMGVDPEKDWKAHYQVLQGKEKVVNELKKLAKDADTIYLATDLDRE 122
           ++     Y +  V    +D +K            +K ++ LKK++KDA+  Y+ATD D E
Sbjct: 62  KFGDYPVYDINWVPASTLDEKKYI----------QKYIDALKKVSKDANKFYVATDWDIE 111

Query: 123 GEAIAWH-LQELLGKKDKTYQRVVFNEITKNAIQDAFSDPGELNISRVNAQQARRFLDRV 181
           GE I +H L    G+K+    R+ F+ +TK  I  A+ +P E++   V+A  +R  +D  
Sbjct: 112 GELIGYHALNFSCGQKNA--HRLRFSSLTKKEILKAYENPNEIDFGLVDAGDSRHKIDWY 169

Query: 182 VGFMVSPLLWKKIA-----RGLSAGRVQSVAVRLVVEREREIKAFVPEEFWDVHADLTSQ 236
            G  VS  L + ++     + LS GRVQ  A+  +V++E EI+ FVP  +W + A L + 
Sbjct: 170 FGINVSRALMQAVSSVKRWKTLSTGRVQGPALAFLVDKELEIRNFVPTPYWVLEALLDND 229

Query: 237 QKAALRMLVAKHQGNAFKPKNKAETDKALADLEGANYKVESRESKPTQS-RPSAPFITST 295
                  L+A H+   F  + +A  +KA   ++G      S   K  ++  P+ PF    
Sbjct: 230 -------LIAVHELEKFWDEEQA--NKAYEKVKGQKQATVSDVKKSMKTIPPNPPFDLGA 280

Query: 296 LQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQEA--LDSARAYISDNFGDK 353
           LQ+ A     F  KKT  +AQ+LYE GY +Y RT S  L  +   +D     +S N   K
Sbjct: 281 LQREAHNMFRFSPKKTQEVAQKLYEKGYCSYPRTSSQKLPDDKAYMDEVLKNLSKNKNYK 340

Query: 354 -YLPDSPNRYG---SKEGAQEAHEAIRPSNVSISAASLGDMERDAQRLYELIWRQFVACQ 409
            Y+    N      S +    AH A+    V +    L D   D  +LYELI R+ +A  
Sbjct: 341 PYIETILNENRKPISGKNDDPAHPAVHA--VDVPKEKLPD---DELKLYELIARRTIALY 395

Query: 410 MTPAKYDATTIKVAAGDYELTAKGRVLKFDGWTRVQPQLRKKGEEELMLPDVQKGDVLDL 469
              AK + + I +          G     +GW  +    +    +E+ LP+++K DV+++
Sbjct: 396 WDNAKREYSKINLDINGETFKLSGSRTVEEGWHEIYYYTKF---DEVELPELKKNDVINV 452

Query: 470 KALDPKQHFTKPVARFNEASLVKELEKRGIGRPSTYASIISTIQDRGYVRLENKRFYAEK 529
             ++ +   TKP  R+  AS++KELEKR +G  +T A I+  +  RGYV +E+       
Sbjct: 453 NNINFEAKETKPPKRYTMASIIKELEKRKLGTKATRADILEKLTKRGYV-IEDGSLTVTD 511

Query: 530 MGEIVNDRLMENFDDLMSYDFTANMEQHLDDIAEGKKNWKDVLNDFYSGFYGKLLNAEKD 589
           +G  V + L +   +++    T ++E  L+ I + K   ++V+ +        L      
Sbjct: 512 LGIGVTETLRKYCPEIVEETLTRDLEDKLELIQDKKIKKEEVIQETKDKLTKILGEFRLK 571

Query: 590 PEEGGMRL-------NQAVPAGVECDKCGREM-NVRTASTGVFLGCSGY-------NLPP 634
            +E G  L       N+++    +C KCG +M  +RT     F+GCS Y        LP 
Sbjct: 572 EKEIGTELVDKLDSTNRSLQIIGKC-KCGGDMIIIRTKGKKRFVGCSNYPDCEVTFPLPQ 630

Query: 635 KER-------CTNTMNLTPGDEVVKV------------DDEEELETEALRSKKRCPKCGT 675
           K R       C    N   G + +K+            +D++E+E +A + +K CPKCG 
Sbjct: 631 KGRIKVLNEVCEKCQNPVIGLDRIKICVNPDCSTRISEEDKKEIE-KAEKEEKICPKCGN 689

Query: 676 AMDSYLVDE--TRKLHVCGNTPTCDGTLVETGTFKIKGYDGPIIECDKCGSDMELKNGRF 733
            +   L+ +        C N P C  T    G    K   G   +C KCGSD+  + GRF
Sbjct: 690 KL---LIKKGPYGVFRGCENYPKCKYTEKLNGESNEKEIVG---KCPKCGSDLYKRKGRF 743

Query: 734 GKYFGCTK-EECKNTRKLLRNGEAAP 758
           G++ GC+   +C++T K+ +  E  P
Sbjct: 744 GEFIGCSNYPKCRHTEKIDKKKEDTP 769