SEED Subsystems in Klebsiella michiganensis M5al

Subsystems are shown if they have at least one gene assigned to them. Because many roles are assigned to more than one subsystem, the subsystem may not be present even if the gene annotation(s) are correct.

Category Subsystem #Genes
Amino Acids and Derivatives L-2-amino-thiazoline-4-carboxylic acid-Lcysteine conversion 3
Amino Acids and Derivatives : Alanine, serine, and glycine Alanine biosynthesis 11
  Glycine Biosynthesis 3
  Glycine and Serine Utilization 32
  Glycine cleavage system 7
  Serine Biosynthesis 11
Amino Acids and Derivatives : Arginine; urea cycle, polyamines Arginine Biosynthesis extended 12
  Arginine Deiminase Pathway 5
  Arginine and Ornithine Degradation 36
  Cyanophycin Metabolism 1
  Polyamine Metabolism 28
  Urea decomposition 20
Amino Acids and Derivatives : Aromatic amino acids and derivatives Aromatic amino acid degradation 13
  Chorismate: Intermediate for synthesis of PAPA antibiotics, PABA, anthranilate, 3-hydroxyanthranilate and more. 11
  Chorismate Synthesis 20
  Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) 18
  Phenylalanine and Tyrosine Branches from Chorismate 5
  Tryptophan synthesis 7
Amino Acids and Derivatives : Branched-chain amino acids Branched-Chain Amino Acid Biosynthesis 21
  Isoleucine degradation 7
  Ketoisovalerate oxidoreductase 1
  Leucine Biosynthesis 9
  Leucine Degradation and HMG-CoA Metabolism 2
  Valine degradation 7
Amino Acids and Derivatives : Glutamine, glutamate, aspartate, asparagine; ammonia assimilation Glutamate dehydrogenases 1
  Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis 34
  Glutamine synthetases 1
Amino Acids and Derivatives : Histidine Metabolism Histidine Biosynthesis 8
  Histidine Degradation 8
Amino Acids and Derivatives : Lysine, threonine, methionine, and cysteine Cysteine Biosynthesis 21
  Lysine Biosynthesis DAP Pathway 11
  Lysine degradation 6
  Methionine Biosynthesis 35
  Methionine Degradation 23
  Methionine Salvage 7
  Threonine anaerobic catabolism gene cluster 9
  Threonine and Homoserine Biosynthesis 21
  Threonine degradation 4
Amino Acids and Derivatives : Proline and 4-hydroxyproline Proline, 4-hydroxyproline uptake and utilization 7
  Proline Synthesis 5
Carbohydrates Unknown sugar utilization (cluster yphABCDEFG) 2
Carbohydrates : Aminosugars Chitin and N-acetylglucosamine utilization 8
  N-Acetyl-Galactosamine and Galactosamine Utilization 7
Carbohydrates : CO2 fixation CO2 uptake, carboxysome 1
  Calvin-Benson cycle 24
  Carboxysome 6
  Photorespiration (oxidative C2 cycle) 20
Carbohydrates : Central carbohydrate metabolism Dihydroxyacetone kinases 5
  Entner-Doudoroff Pathway 19
  Glycolate, glyoxylate interconversions 2
  Glycolysis and Gluconeogenesis 22
  Glycolysis and Gluconeogenesis, including Archaeal enzymes 15
  Methylglyoxal Metabolism 5
  Pentose phosphate pathway 21
  Pyruvate:ferredoxin oxidoreductase 2
  Pyruvate Alanine Serine Interconversions 14
  Pyruvate metabolism I: anaplerotic reactions, PEP 18
  Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate 14
  TCA Cycle 22
Carbohydrates : Di- and oligosaccharides Beta-Glucoside Metabolism 39
  Fructooligosaccharides(FOS) and Raffinose Utilization 11
  Lactose and Galactose Uptake and Utilization 25
  Lactose utilization 10
  Maltose and Maltodextrin Utilization 44
  Melibiose Utilization 3
  Sucrose utilization 10
  Sucrose utilization Shewanella 4
  Trehalose Biosynthesis 8
  Trehalose Uptake and Utilization 15
Carbohydrates : Fermentation Acetoin, butanediol metabolism 15
  Acetyl-CoA fermentation to Butyrate 6
  Butanol Biosynthesis 10
  Fermentations: Lactate 4
  Fermentations: Mixed acid 23
Carbohydrates : Glycoside hydrolases Predicted carbohydrate hydrolases 2
Carbohydrates : Monosaccharides 2-Ketogluconate Utilization 5
  D-Galacturonate and D-Glucuronate Utilization 34
  D-Sorbitol(D-Glucitol) and L-Sorbose Utilization 9
  D-Tagatose and Galactitol Utilization 16
  D-allose utilization 6
  D-galactarate, D-glucarate and D-glycerate catabolism 15
  D-galactonate catabolism 8
  D-gluconate and ketogluconates metabolism 13
  D-ribose utilization 23
  Deoxyribose and Deoxynucleoside Catabolism 17
  Fructose utilization 15
  Hexose Phosphate Uptake System 8
  L-Arabinose utilization 16
  L-ascorbate utilization (and related gene clusters) 17
  L-fucose utilization 10
  L-fucose utilization temp 1
  L-rhamnose utilization 22
  Mannose Metabolism 3
  Xylose utilization 19
Carbohydrates : One-carbon Metabolism One-carbon metabolism by tetrahydropterines 4
  Serine-glyoxylate cycle 29
Carbohydrates : Organic acids Alpha-acetolactate operon 2
  Isobutyryl-CoA to Propionyl-CoA Module 2
  Lactate utilization 3
  Malonate decarboxylase 16
  Propionate-CoA to Succinate Module 2
  Propionyl-CoA to Succinyl-CoA Module 1
  Tricarballylate Utilization 4
Carbohydrates : Polysaccharides Glycogen metabolism 8
Carbohydrates : Sugar alcohols Di-Inositol-Phosphate biosynthesis 2
  Ethanolamine utilization 24
  Glycerol and Glycerol-3-phosphate Uptake and Utilization 19
  Glycerol fermenation to 1,3-propanediol 1
  Inositol catabolism 24
  Mannitol Utilization 10
  Propanediol utilization 22
  Ribitol, Xylitol, Arabitol, Mannitol and Sorbitol utilization 17
Cell Division and Cell Cycle Bacterial Cytoskeleton 21
  Control of cell elongation - division cycle in Bacilli 1
  Macromolecular synthesis operon 5
  MukBEF Chromosome Condensation 5
  Two cell division clusters relating to chromosome partitioning 4
Cell Wall and Capsule Peptidoglycan Biosynthesis 28
  UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis 9
Cell Wall and Capsule : Capsular and extracellular polysacchrides Alginate metabolism 5
  CMP-N-acetylneuraminate Biosynthesis 1
  Capsular heptose biosynthesis 4
  Colanic acid biosynthesis 4
  O-Methyl Phosphoramidate Capsule Modification in Campylobacter 1
  Polysaccharide deacetylases 1
  Rhamnose containing glycans 8
  Sialic Acid Metabolism 24
  dTDP-rhamnose synthesis 7
Cell Wall and Capsule : Cell wall of Mycobacteria linker unit-arabinogalactan synthesis 7
  mycolic acid synthesis 13
Cell Wall and Capsule : Gram-Negative cell wall components KDO2-Lipid A biosynthesis 16
  LOS core oligosaccharide biosynthesis 16
  Lipid A-Ara4N pathway ( Polymyxin resistance ) 7
  Lipid A modifications 8
  Lipopolysaccharide-related cluster in Alphaproteobacteria 1
Cell Wall and Capsule : Gram-Positive cell wall components Teichoic and lipoteichoic acids biosynthesis 3
  Teichuronic acid biosynthesis 2
Clustering-based subsystems Bacterial Cell Division 26
  Bacterial RNA-metabolizing Zn-dependent hydrolases 7
  CBSS-214092.1.peg.3450 5
  CBSS-562.2.peg.5158 SK3 including 6
  Conserved gene cluster associated with Met-tRNA formyltransferase 15
  LMPTP YwlE cluster 4
  NusA-TFII Cluster 5
  PA0057 cluster 2
  Putative hemin transporter 2
  Putative sulfate assimilation cluster 3
Clustering-based subsystems : Clustering-based subsystems CBSS-262719.3.peg.410 2
Clustering-based subsystems : Lysine, threonine, methionine, and cysteine YeiH 4
Clustering-based subsystems : proteosome related Cluster-based Subsystem Grouping Hypotheticals - perhaps Proteosome Related 2
Cofactors, Vitamins, Prosthetic Groups, Pigments Thiamin biosynthesis 14
Cofactors, Vitamins, Prosthetic Groups, Pigments : Biotin Biotin biosynthesis 9
Cofactors, Vitamins, Prosthetic Groups, Pigments : Coenzyme A Coenzyme A Biosynthesis 11
Cofactors, Vitamins, Prosthetic Groups, Pigments : Folate and pterines Folate Biosynthesis 25
  Molybdenum cofactor biosynthesis 14
  Pterin biosynthesis 2
  p-Aminobenzoyl-Glutamate Utilization 6
Cofactors, Vitamins, Prosthetic Groups, Pigments : Lipoic acid Lipoic acid metabolism 6
Cofactors, Vitamins, Prosthetic Groups, Pigments : NAD and NADP NAD and NADP cofactor biosynthesis global 21
  NAD regulation 12
  PnuC-like transporters 4
Cofactors, Vitamins, Prosthetic Groups, Pigments : Pyridoxine Pyridoxin (Vitamin B6) Biosynthesis 21
Cofactors, Vitamins, Prosthetic Groups, Pigments : Quinone cofactors Menaquinone and Phylloquinone Biosynthesis 5
  Plastoquinone Biosynthesis 3
  Tocopherol Biosynthesis 3
  Ubiquinone Biosynthesis 14
Cofactors, Vitamins, Prosthetic Groups, Pigments : Riboflavin, FMN, FAD Flavodoxin 5
  Riboflavin, FMN and FAD metabolism 3
Cofactors, Vitamins, Prosthetic Groups, Pigments : Tetrapyrroles Cobalamin synthesis 18
  Coenzyme B12 biosynthesis 30
  Experimental tye 14
  Heme and Siroheme Biosynthesis 14
DNA Metabolism DNA structural proteins, bacterial 8
  Restriction-Modification System 9
  YcfH 3
DNA Metabolism : CRISPs CRISPRs 2
DNA Metabolism : DNA recombination RuvABC plus a hypothetical 3
DNA Metabolism : DNA repair 2-phosphoglycolate salvage 6
  DNA Repair Base Excision 12
  DNA repair, UvrABC system 5
  DNA repair, bacterial 29
  DNA repair, bacterial DinG and relatives 2
  DNA repair, bacterial MutL-MutS system 2
  DNA repair, bacterial RecFOR pathway 8
  DNA repair, bacterial UvrD and related helicases 3
DNA Metabolism : DNA replication DNA-replication 39
  DNA replication, archaeal 1
  DNA topoisomerases, Type I, ATP-independent 3
  DNA topoisomerases, Type II, ATP-dependent 4
Fatty Acids, Lipids, and Isoprenoids Polyhydroxybutyrate metabolism 3
Fatty Acids, Lipids, and Isoprenoids : Fatty acids Fatty Acid Biosynthesis FASII 21
Fatty Acids, Lipids, and Isoprenoids : Isoprenoids Archaeal lipids 2
  Carotenoids 1
  Isoprenoid Biosynthesis 9
  Polyprenyl Diphosphate Biosynthesis 1
  polyprenyl synthesis 6
Fatty Acids, Lipids, and Isoprenoids : Phospholipids Glycerolipid and Glycerophospholipid Metabolism in Bacteria 33
Fatty Acids, Lipids, and Isoprenoids : Triacylglycerols Triacylglycerol metabolism 1
Iron acquisition and metabolism Campylobacter Iron Metabolism 12
  Heme, hemin uptake and utilization systems in GramPositives 2
  Hemin transport system 7
  Iron acquisition in Vibrio 25
  Transport of Iron 18
Iron acquisition and metabolism : Siderophores Siderophore Aerobactin 5
  Siderophore Enterobactin 14
Membrane Transport ECF class transporters 8
  Ton and Tol transport systems 21
  Transport of Manganese 6
  Transport of Molybdenum 4
  Transport of Nickel and Cobalt 11
  Transport of Zinc 8
Membrane Transport : ABC transporters ABC transporter alkylphosphonate (TC 3.A.1.9.1) 5
  ABC transporter branched-chain amino acid (TC 3.A.1.4.1) 15
  ABC transporter dipeptide (TC 3.A.1.5.2) 18
  ABC transporter oligopeptide (TC 3.A.1.5.1) 19
  ABC transporter peptide (TC 3.A.1.5.5) 3
Membrane Transport : Protein and nucleoprotein secretion system, Type IV Type IV pilus 11
  pVir Plasmid of Campylobacter 2
Membrane Transport : Protein secretion system, Type III Type III secretion system orphans 2
Membrane Transport : Protein secretion system, Type VIII (Extracellular nucleation/precipitation pathway, ENP) Curli production 1
Membrane Transport : Protein translocation across cytoplasmic membrane Twin-arginine translocation system 5
Membrane Transport : Sugar Phosphotransferase Systems, PTS Fructose and Mannose Inducible PTS 3
Membrane Transport : Uni- Sym- and Antiporters Na(+) H(+) antiporter 1
Metabolism of Aromatic Compounds Aromatic Amin Catabolism 8
  Benzoate transport and degradation cluster 2
  Gentisare degradation 7
Metabolism of Aromatic Compounds : Metabolism of central aromatic intermediates 4-Hydroxyphenylacetic acid catabolic pathway 13
  Catechol branch of beta-ketoadipate pathway 8
  Central meta-cleavage pathway of aromatic compound degradation 7
  Homogentisate pathway of aromatic compound degradation 6
  Protocatechuate branch of beta-ketoadipate pathway 13
  Salicylate and gentisate catabolism 10
Metabolism of Aromatic Compounds : Peripheral pathways for catabolism of aromatic compounds Benzoate degradation 6
  Biphenyl Degradation 1
  Chloroaromatic degradation pathway 3
  Phenylpropanoid compound degradation 5
  Quinate degradation 4
  Salicylate ester degradation 2
  n-Phenylalkanoic acid degradation 4
  p-Hydroxybenzoate degradation 5
Miscellaneous Muconate lactonizing enzyme family 3
  YaaA 1
  YbbK 3
  ZZ gjo need homes 15
Miscellaneous : Plant-Prokaryote DOE project Conserved gene cluster possibly involved in RNA metabolism 3
  Synechocystis experimental 1
Motility and Chemotaxis Bacterial Chemotaxis 10
Motility and Chemotaxis : Flagellar motility in Prokaryota Flagellar motility 2
  Flagellum 3
  Flagellum in Campylobacter 3
Nitrogen Metabolism Allantoin Utilization 14
  Ammonia assimilation 11
  Cyanate hydrolysis 4
  Dissimilatory nitrite reductase 2
  Nitrate and nitrite ammonification 23
  Nitric oxide synthase 1
  Nitrogen fixation 14
  Nitrosative stress 7
Nucleosides and Nucleotides Adenosyl nucleosidases 3
  Hydantoin metabolism 4
  Ribonucleotide reduction 9
Nucleosides and Nucleotides : Detoxification Nudix proteins (nucleoside triphosphate hydrolases) 16
Nucleosides and Nucleotides : Purines De Novo Purine Biosynthesis 13
  Purine Utilization 14
  Purine conversions 23
  Purine nucleotide synthesis regulator 1
  Xanthosine utilization (xap region) 3
Nucleosides and Nucleotides : Pyrimidines De Novo Pyrimidine Synthesis 11
  Pyrimidine utilization 11
Phages, Prophages, Transposable elements : Bacteriophage structural proteins Phage capsid proteins 3
Phages, Prophages, Transposable elements, Plasmids : Pathogenicity islands Staphylococcal pathogenicity islands SaPI 10
Phages, Prophages, Transposable elements, Plasmids : Phages, Prophages IbrA and IbrB: co-activators of prophage gene expression 4
  Staphylococcal phi-Mu50B-like prophages 1
Phages, Prophages, Transposable elements, Plasmids : Transposable elements Tn552 1
Phosphorus Metabolism Alkylphosphonate utilization 14
  High affinity phosphate transporter and control of PHO regulon 9
  Phosphate metabolism 29
Potassium metabolism Glutathione-regulated potassium-efflux system and associated functions 6
  Potassium homeostasis 19
Protein Metabolism : Protein biosynthesis Ribosome LSU bacterial 30
  Ribosome SSU bacterial 19
  Ribosome activity modulation 3
  Ribosome biogenesis bacterial 14
  Trans-translation by stalled ribosomes 1
  Translation elongation factor G family 2
  Translation elongation factors eukaryotic and archaeal 1
  Translation initiation factors eukaryotic and archaeal 4
  Universal GTPases 18
  tRNA aminoacylation, Asp and Asn 2
  tRNA aminoacylation, Glu and Gln 2
Protein Metabolism : Protein degradation Proteasome bacterial 6
  Protein degradation 3
  Proteolysis in bacteria, ATP-dependent 13
  Putative TldE-TldD proteolytic complex 1
Protein Metabolism : Protein folding GroEL GroES 2
  Peptidyl-prolyl cis-trans isomerase 4
  Periplasmic disulfide interchange 5
  Protein chaperones 9
Protein Metabolism : Protein processing and modification Ribosomal protein S12p Asp methylthiotransferase 3
  Ribosomal protein S5p acylation 2
  Signal peptidase 2
Protein Metabolism : Selenoproteins Glycine reductase, sarcosine reductase and betaine reductase 3
  Selenocysteine metabolism 4
RNA Metabolism : RNA processing and modification ATP-dependent RNA helicases, bacterial 3
  Polyadenylation bacterial 4
  Queuosine-Archaeosine Biosynthesis 22
  RNA 3'-terminal phosphate cyclase 1
  RNA processing and degradation, bacterial 9
  Ribonuclease H 2
  Wyeosine-MimG Biosynthesis 3
  tRNA nucleotidyltransferase 1
  tRNA processing 10
RNA Metabolism : Transcription RNA polymerase bacterial 4
  Rrf2 family transcriptional regulators 4
  Transcription factors bacterial 10
  Transcription factors cyanobacterial RpoD-like sigma factors 1
  Transcription initiation, bacterial sigma factors 9
Regulation and Cell signaling CytR regulation 2
  DNA-binding regulatory proteins, strays 21
  Orphan regulatory proteins 23
  Pseudomonas quinolone signal PQS 1
  Sex pheromones in Enterococcus faecalis and other Firmicutes 7
  Stringent Response, (p)ppGpp metabolism 3
  cAMP signaling in bacteria 10
Regulation and Cell signaling : Programmed Cell Death and Toxin-antitoxin Systems Murein hydrolase regulation and cell death 12
Regulation and Cell signaling : Quorum sensing and biofilm formation Autoinducer 2 (AI-2) transport and processing (lsrACDBFGE operon) 9
  Quorum Sensing: Autoinducer-2 Synthesis 1
  Quorum sensing regulation in Pseudomonas 1
Respiration Biogenesis of c-type cytochromes 4
  Biogenesis of cytochrome c oxidases 2
  Formate hydrogenase 17
  Soluble cytochromes and functionally related electron carriers 3
Respiration : ATP synthases F0F1-type ATP synthase 7
Respiration : Electron accepting reactions Anaerobic respiratory reductases 7
  Terminal cytochrome O ubiquinol oxidase 4
  Terminal cytochrome d ubiquinol oxidases 10
  Terminal cytochrome oxidases 14
  Tetrathionate respiration 2
Respiration : Electron donating reactions Coenzyme F420 hydrogenase 1
  Formate dehydrogenase 7
  Hydrogenases 2
  Na(+)-translocating NADH-quinone oxidoreductase and rnf-like group of electron transport complexes 14
  NiFe hydrogenase maturation 6
  Respiratory Complex I 13
  Respiratory dehydrogenases 1 12
  Succinate dehydrogenase 9
Respiration : Sodium Ion-Coupled Energetics Na+ translocating decarboxylases and related biotin-dependent enzymes 7
Secondary Metabolism : Aromatic amino acids and derivatives Cinnamic Acid Degradation 9
Secondary Metabolism : Bacterial cytostatics, differentiation factors and antibiotics Phenazine biosynthesis 1
Secondary Metabolism : Biosynthesis of phenylpropanoids Phenylpropionate Degradation 1
Secondary Metabolism : Plant Hormones Auxin biosynthesis 5
  Auxin degradation 1
Stress Response Bacterial hemoglobins 7
  Dimethylarginine metabolism 1
  Flavohaemoglobin 2
  Hfl operon 5
  Sugar-phosphate stress regulation 1
  Universal stress protein family 8
Stress Response : Acid stress Acid resistance mechanisms 1
Stress Response : Detoxification Glutathione-dependent pathway of formaldehyde detoxification 2
Stress Response : Heat shock Heat shock dnaK gene cluster extended 15
Stress Response : Osmotic stress Choline and Betaine Uptake and Betaine Biosynthesis 9
Stress Response : Oxidative stress Glutaredoxins 7
  Glutathione: Biosynthesis and gamma-glutamyl cycle 4
  Glutathione: Non-redox reactions 14
  Glutathione: Redox cycle 5
  Glutathionylspermidine and Trypanothione 2
  Oxidative stress 21
  Redox-dependent regulation of nucleus processes 6
  Rubrerythrin 1
Sulfur Metabolism Galactosylceramide and Sulfatide metabolism 7
  Sulfate reduction-associated complexes 1
  Sulfur oxidation 2
  Thioredoxin-disulfide reductase 8
Sulfur Metabolism : Organic sulfur assimilation Alkanesulfonate assimilation 17
  Alkanesulfonates Utilization 12
  Taurine Utilization 4
  Utilization of glutathione as a sulphur source 3
Virulence : Type III, Type IV, Type VI, ESAT secretion systems Type 4 secretion and conjugative transfer 1
Virulence, Disease and Defense : Detection MLST 6
Virulence, Disease and Defense : Resistance to antibiotics and toxic compounds Arsenic resistance 5
  Beta-lactamase 1
  Cobalt-zinc-cadmium resistance 10
  Copper homeostasis 4
  Copper homeostasis: copper tolerance 10
  Fosfomycin resistance 1
  Methicillin resistance in Staphylococci 3
  Multidrug Resistance, Tripartite Systems Found in Gram Negative Bacteria 8
  Multidrug Resistance Efflux Pumps 22
  Multidrug efflux pump in Campylobacter jejuni (CmeABC operon) 9
  Resistance to fluoroquinolones 4
  Zinc resistance 3