SEED Subsystem: Folate Biosynthesis in Pseudomonas fluorescens FW300-N2E3

Experiments:

Role Gene Name  
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) AO353_07355
  AO353_14390
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) AO353_08780
5-nucleotidase SurE (EC 3.1.3.5) No genes
6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12) No genes
ATPase component of general energizing module of ECF transporters No genes
Alternative Folylglutamate Synthase No genes
Alternative dihydrofolate reductase 2 No genes
Alternative dihydrofolate reductase 3 No genes
Aminodeoxychorismate lyase (EC 4.1.3.38) AO353_01350
COG0488: ATPase components of ABC transporters with duplicated ATPase domains AO353_00525
Dihydrofolate reductase (EC 1.5.1.3) AO353_08370
  AO353_28310
Dihydrofolate synthase (EC 6.3.2.12) No genes
Dihydroneopterin aldolase (EC 4.1.2.25) AO353_07360
Dihydroneopterin triphosphate epimerase AO353_04965
Dihydroneopterin triphosphate pyrophosphohydolase No genes
Dihydroneopterin triphosphate pyrophosphohydolase type 2 No genes
Dihydropteroate synthase (EC 2.5.1.15) AO353_05600
FolM Alternative dihydrofolate reductase 1 AO353_04955
Folate biosynthesis protein PTPS-III, catalyzes a reaction that bypasses dihydroneopterin aldolase (FolB) No genes
Folate transporter 3 No genes
Folylpolyglutamate synthase (EC 6.3.2.17) No genes
Formate--tetrahydrofolate ligase (EC 6.3.4.3) No genes
GTP cyclohydrolase I (EC 3.5.4.16) type 1 AO353_02285
  AO353_04960
GTP cyclohydrolase I (EC 3.5.4.16) type 2 AO353_10125
Methionyl-tRNA formyltransferase (EC 2.1.2.9) AO353_10635
Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) AO353_20145
Non functional Dihydropteroate synthase 2 No genes
Nucleoside triphosphate pyrophosphohydrolase MazG No genes
Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85) AO353_01150
Para-aminobenzoate synthase, aminase component (EC 2.6.1.85) AO353_00925
PqqC-like protein No genes
Putative DHNTP pyrophosphatase No genes
Related to Dihydropteroate synthase No genes
Serine hydroxymethyltransferase (EC 2.1.2.1) AO353_07665
  AO353_10495
  AO353_10530
  AO353_14020
  AO353_14025
  AO353_29335
Substrate-specific component FolT of folate ECF transporter No genes
Thymidine kinase (EC 2.7.1.21) No genes
Thymidylate synthase (EC 2.1.1.45) AO353_08445
Thymidylate synthase thyX (EC 2.1.1.-) No genes
Transaldolase (EC 2.2.1.2) AO353_00310
Transmembrane component of general energizing module of ECF transporters No genes
Xanthosine/inosine triphosphate pyrophosphatase No genes
alternate gene name: yzbB AO353_19975

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