SEED Subsystem: Folate Biosynthesis in Sinorhizobium meliloti 1021

Experiments:

Role Gene Name  
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) SMc00465
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) SMc02594
  SMc03974
5-nucleotidase SurE (EC 3.1.3.5) SMc02063
6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12) No genes
ATPase component of general energizing module of ECF transporters No genes
Alternative Folylglutamate Synthase No genes
Alternative dihydrofolate reductase 2 No genes
Alternative dihydrofolate reductase 3 No genes
Aminodeoxychorismate lyase (EC 4.1.3.38) SMc04014
COG0488: ATPase components of ABC transporters with duplicated ATPase domains No genes
Dihydrofolate reductase (EC 1.5.1.3) SMa1326
  SMc01442
  SMc02439
  SMc04173
Dihydrofolate synthase (EC 6.3.2.12) SMc02763
Dihydroneopterin aldolase (EC 4.1.2.25) SMc00463
Dihydroneopterin triphosphate epimerase No genes
Dihydroneopterin triphosphate pyrophosphohydolase No genes
Dihydroneopterin triphosphate pyrophosphohydolase type 2 No genes
Dihydropteroate synthase (EC 2.5.1.15) SMc00462
FolM Alternative dihydrofolate reductase 1 SMc00603
Folate biosynthesis protein PTPS-III, catalyzes a reaction that bypasses dihydroneopterin aldolase (FolB) No genes
Folate transporter 3 No genes
Folylpolyglutamate synthase (EC 6.3.2.17) SMc02763
Formate--tetrahydrofolate ligase (EC 6.3.4.3) SMc02728
GTP cyclohydrolase I (EC 3.5.4.16) type 1 SMc01005
GTP cyclohydrolase I (EC 3.5.4.16) type 2 No genes
Methionyl-tRNA formyltransferase (EC 2.1.2.9) SM_b21235
  SMc01100
  SMc04334
Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) SMc02604
  SMc03059
Non functional Dihydropteroate synthase 2 No genes
Nucleoside triphosphate pyrophosphohydrolase MazG No genes
Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85) SMc03943
Para-aminobenzoate synthase, aminase component (EC 2.6.1.85) SMc04013
PqqC-like protein No genes
Putative DHNTP pyrophosphatase No genes
Related to Dihydropteroate synthase No genes
Serine hydroxymethyltransferase (EC 2.1.2.1) SMa2135
  SMc01770
Substrate-specific component FolT of folate ECF transporter No genes
Thymidine kinase (EC 2.7.1.21) SMc02736
Thymidylate synthase (EC 2.1.1.45) SMc01444
Thymidylate synthase thyX (EC 2.1.1.-) No genes
Transaldolase (EC 2.2.1.2) SMc02495
Transmembrane component of general energizing module of ECF transporters No genes
Xanthosine/inosine triphosphate pyrophosphatase No genes
alternate gene name: yzbB No genes

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