| Role | Gene | Name | |
|---|
| 5,6-dimethylbenzimidazole synthase, flavin destructase family | No genes | | |
| ATPase component CbiO of energizing module of cobalt ECF transporter | No genes | | |
| Additional lipoprotein component of predicted cobalamin ECF transporter | No genes | | |
| Additional substrate-specific component CbiN of cobalt ECF transporter | No genes | | |
| Adenosylcobinamide amidohydrolase (EC 3.5.1.90) | No genes | | |
| Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) | SMc04305 | | |
| Adenosylcobinamide-phosphate synthase | No genes | | |
| Aerobic cobaltochelatase CobS subunit (EC 6.6.1.2) | SMc00700 | | |
| Aerobic cobaltochelatase CobT subunit (EC 6.6.1.2) | SMc00701 | | |
| Alpha-ribazole-5'-phosphate phosphatase (EC 3.1.3.73) | No genes | | |
| CblX, a non-orthologous displasment for Alpha-ribazole-5'-phosphate phosphatase | SMc04216 | | |
| CblY, a non-orthologous displasment for Alpha-ribazole-5'-phosphate phosphatase | SMc04217 | | |
| CblZ, a non-orthologous displasment for Alpha-ribazole-5'-phosphate phosphatase | No genes | | |
| ChlD component of cobalt chelatase involved in B12 biosynthesis | No genes | | |
| ChlI component of cobalt chelatase involved in B12 biosynthesis | No genes | | |
| Cob(I)alamin adenosyltransferase (EC 2.5.1.17) | SMc04302 | | |
| Cob(I)alamin adenosyltransferase PduO (EC 2.5.1.17) | No genes | | |
| Cob(II)alamin reductase | No genes | | |
| CobN component of cobalt chelatase involved in B12 biosynthesis | SMc04303 | | |
| CobW GTPase involved in cobalt insertion for B12 biosynthesis | SMc04304 | | |
| Cobalamin biosynthesis protein CbiG | SMc04285 | | |
| Cobalamin biosynthesis protein CobG | SMc03193 | | |
| Cobalamin synthase | No genes | | |
| Cobalamine-related hypothetical metal-binding protein CrdX | No genes | | |
| Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130) | SMc03191 | | |
| Cobalt-precorrin-3b C17-methyltransferase | SMc03190 | | |
| | SMc04285 | | |
| Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133) | SMc03187 | | |
| Cobalt-precorrin-6 synthase, anaerobic | No genes | | |
| Cobalt-precorrin-6x reductase (EC 1.3.1.54) | SMc03189 | | |
| Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-) | SMc03188 | | |
| Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) | SMc03188 | | |
| Cobalt-precorrin-8x methylmutase (EC 5.4.1.2) | SMc03192 | | |
| Cobyric acid synthase | No genes | | |
| Cobyrinic acid A,C-diamide synthase | SMc04282 | | |
| Duplicated ATPase component CbrU of energizing module of predicted cobalamin ECF transporter | No genes | | |
| HoxN/HupN/NixA family cobalt transporter | No genes | | |
| HupE-UreJ family cobalt transporter | No genes | | |
| L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) | SMc04281 | | |
| Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) | SMc04214 | | |
| Optional hypothetical component of the B12 transporter BtuM | No genes | | |
| Optional hypothetical component of the B12 transporter BtuN | No genes | | |
| Outer membrane vitamin B12 receptor BtuB | No genes | | |
| Precorrin-6A synthase (EC 2.1.1.152) | SMc03194 | | |
| Predicted adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62) | No genes | | |
| Predicted alpha-ribazole-5'-phosphate phosphatase CobZ (EC 3.1.3.73) | No genes | | |
| Predicted alpha-ribazole-5-phosphate synthase CblS for cobalamin biosynthesis | No genes | | |
| Predicted cobalt ABC transporter periplasmic component | No genes | | |
| Predicted cobalt transporter CbtA | No genes | | |
| Predicted cobalt transporter CbtC | SM_b20556 | | |
| Predicted cobalt transporter in Bacteroides_Porphyromonas | No genes | | |
| Predicted cobalt transporter in Mycobacteria | No genes | | |
| Predicted cobalt transporter in Thermoplasma | No genes | | |
| Predicted cobalt transporter in sulfate-reducing delta-proteobacteria | No genes | | |
| Putative 2Fe-2S ferredoxin CbiW involved in B12 biosynthesis | No genes | | |
| Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) | No genes | | |
| Sirohydrochlorin cobaltochelatase CbiK (EC 4.99.1.3) | No genes | | |
| Substrate-specific component CbiM of cobalt ECF transporter | No genes | | |
| Substrate-specific component CblT of predicted B12-regulated ECF transporter for dimethylbenzimidazole | No genes | | |
| Substrate-specific component CbrT of predicted cobalamin ECF transporter | No genes | | |
| Threonine kinase in B12 biosynthesis | No genes | | |
| Transmembrane component CbiQ of energizing module of cobalt ECF transporter | No genes | | |
| Transmembrane component CbrV of energizing module of predicted cobalamin ECF transporter | No genes | | |
| Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) | SM_b20987 | | |
| | SMc01053 | | |
| | SMc04284 | | |
| Vitamin B12 ABC transporter, ATPase component BtuD | No genes | | |
| Vitamin B12 ABC transporter, B12-binding component BtuF | No genes | | |
| Vitamin B12 ABC transporter, permease component BtuC | No genes | | |