SEED Subsystem: Coenzyme B12 biosynthesis in Phaeobacter inhibens DSM 17395

Experiments:

Role Gene Name  
5,6-dimethylbenzimidazole synthase, flavin destructase family No genes
ATPase component CbiO of energizing module of cobalt ECF transporter No genes
Additional lipoprotein component of predicted cobalamin ECF transporter No genes
Additional substrate-specific component CbiN of cobalt ECF transporter No genes
Adenosylcobinamide amidohydrolase (EC 3.5.1.90) No genes
Adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) PGA1_c26670
Adenosylcobinamide-phosphate synthase No genes
Aerobic cobaltochelatase CobS subunit (EC 6.6.1.2) PGA1_c09780
Aerobic cobaltochelatase CobT subunit (EC 6.6.1.2) PGA1_c09770
Alpha-ribazole-5'-phosphate phosphatase (EC 3.1.3.73) No genes
CblX, a non-orthologous displasment for Alpha-ribazole-5'-phosphate phosphatase No genes
CblY, a non-orthologous displasment for Alpha-ribazole-5'-phosphate phosphatase No genes
CblZ, a non-orthologous displasment for Alpha-ribazole-5'-phosphate phosphatase No genes
ChlD component of cobalt chelatase involved in B12 biosynthesis No genes
ChlI component of cobalt chelatase involved in B12 biosynthesis No genes
Cob(I)alamin adenosyltransferase (EC 2.5.1.17) PGA1_c08200
Cob(I)alamin adenosyltransferase PduO (EC 2.5.1.17) No genes
Cob(II)alamin reductase No genes
CobN component of cobalt chelatase involved in B12 biosynthesis PGA1_c08170
CobW GTPase involved in cobalt insertion for B12 biosynthesis PGA1_c08180
Cobalamin biosynthesis protein CbiG No genes
Cobalamin biosynthesis protein CobG PGA1_c08160
Cobalamin synthase No genes
Cobalamine-related hypothetical metal-binding protein CrdX No genes
Cobalt-precorrin-2 C20-methyltransferase (EC 2.1.1.130) PGA1_c08140
Cobalt-precorrin-3b C17-methyltransferase PGA1_c08130
Cobalt-precorrin-4 C11-methyltransferase (EC 2.1.1.133) PGA1_c08090
Cobalt-precorrin-6 synthase, anaerobic No genes
Cobalt-precorrin-6x reductase (EC 1.3.1.54) PGA1_c08120
Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-) PGA1_c08110
Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) PGA1_c08110
Cobalt-precorrin-8x methylmutase (EC 5.4.1.2) PGA1_c08150
Cobyric acid synthase No genes
Cobyrinic acid A,C-diamide synthase PGA1_c08080
Duplicated ATPase component CbrU of energizing module of predicted cobalamin ECF transporter No genes
HoxN/HupN/NixA family cobalt transporter No genes
HupE-UreJ family cobalt transporter No genes
L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81) PGA1_c00830
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (EC 2.4.2.21) PGA1_c07570
Optional hypothetical component of the B12 transporter BtuM No genes
Optional hypothetical component of the B12 transporter BtuN No genes
Outer membrane vitamin B12 receptor BtuB No genes
Precorrin-6A synthase (EC 2.1.1.152) PGA1_c08050
Predicted adenosylcobinamide-phosphate guanylyltransferase CobY (EC 2.7.7.62) No genes
Predicted alpha-ribazole-5'-phosphate phosphatase CobZ (EC 3.1.3.73) No genes
Predicted alpha-ribazole-5-phosphate synthase CblS for cobalamin biosynthesis No genes
Predicted cobalt ABC transporter periplasmic component No genes
Predicted cobalt transporter CbtA No genes
Predicted cobalt transporter CbtC PGA1_c08060
Predicted cobalt transporter in Bacteroides_Porphyromonas No genes
Predicted cobalt transporter in Mycobacteria No genes
Predicted cobalt transporter in Thermoplasma No genes
Predicted cobalt transporter in sulfate-reducing delta-proteobacteria No genes
Putative 2Fe-2S ferredoxin CbiW involved in B12 biosynthesis No genes
Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) No genes
Sirohydrochlorin cobaltochelatase CbiK (EC 4.99.1.3) No genes
Substrate-specific component CbiM of cobalt ECF transporter No genes
Substrate-specific component CblT of predicted B12-regulated ECF transporter for dimethylbenzimidazole No genes
Substrate-specific component CbrT of predicted cobalamin ECF transporter No genes
Threonine kinase in B12 biosynthesis No genes
Transmembrane component CbiQ of energizing module of cobalt ECF transporter No genes
Transmembrane component CbrV of energizing module of predicted cobalamin ECF transporter No genes
Uroporphyrinogen-III methyltransferase (EC 2.1.1.107) PGA1_c20740
  PGA1_c08070
Vitamin B12 ABC transporter, ATPase component BtuD No genes
Vitamin B12 ABC transporter, B12-binding component BtuF No genes
Vitamin B12 ABC transporter, permease component BtuC No genes

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