SEED Subsystem: Valine degradation in Mycobacterium tuberculosis H37Rv

Experiments:

Role Gene Name  
3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35) Rv0860
3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31) Rv0751c
  Rv0770
3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4) Rv1071c
Branched-chain acyl-CoA dehydrogenase (EC 1.3.99.12) Rv0752c
Branched-chain alpha-keto acid dehydrogenase, E1 component, alpha subunit (EC 1.2.4.4) Rv2497c
Branched-chain alpha-keto acid dehydrogenase, E1 component, beta subunit (EC 1.2.4.4) Rv2496c
Branched-chain amino acid aminotransferase (EC 2.6.1.42) Rv2210c
Butyrate kinase (EC 2.7.2.7) No genes
Butyryl-CoA dehydrogenase (EC 1.3.99.2) Rv0154c
  Rv0215c
  Rv0271c
  Rv1933c
  Rv1934c
  Rv2789c
  Rv3061c
  Rv3139
  Rv3564
Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex (EC 2.3.1.168) Rv2215
  Rv2495c
Dihydrolipoamide dehydrogenase of branched-chain alpha-keto acid dehydrogenase (EC 1.8.1.4) No genes
Enoyl-CoA hydratase (EC 4.2.1.17) Rv0222
  Rv0456c
  Rv0632c
  Rv0675
  Rv0905
  Rv1070c
  Rv1136
  Rv1141c
  Rv1142c
  Rv1472
  Rv1935c
  Rv2486
  Rv2679
  Rv2831
  Rv3039c
  Rv3373
  Rv3374
  Rv3516
Enoyl-CoA hydratase [valine degradation] (EC 4.2.1.17) No genes
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex (EC 2.3.1.-) No genes
Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27) Rv0753c
Predicted transcriptional regulator of leucine degradation pathway, MerR family No genes
Probable acyl-CoA dehydrogenase (EC 1.3.99.3) No genes
Transcriptional regulator BkdR of isoleucine and valine catabolism operon No genes
phosphotransbutyrylase (EC 2.3.1.19) No genes

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