SEED Subsystem: Folate Biosynthesis in Shewanella oneidensis MR-1

Experiments:

Role Gene Name  
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) SO0871 folK-1
  SO1292 folK-2
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) SO0774
5-nucleotidase SurE (EC 3.1.3.5) No genes
6-pyruvoyl tetrahydrobiopterin synthase (EC 4.2.3.12) No genes
ATPase component of general energizing module of ECF transporters No genes
Alternative Folylglutamate Synthase No genes
Alternative dihydrofolate reductase 2 No genes
Alternative dihydrofolate reductase 3 No genes
Aminodeoxychorismate lyase (EC 4.1.3.38) SO2615 pabC
COG0488: ATPase components of ABC transporters with duplicated ATPase domains No genes
Dihydrofolate reductase (EC 1.5.1.3) SO3646 folA
Dihydrofolate synthase (EC 6.3.2.12) No genes
Dihydroneopterin aldolase (EC 4.1.2.25) SO1291 folB
Dihydroneopterin triphosphate epimerase SO2921 folX
Dihydroneopterin triphosphate pyrophosphohydolase No genes
Dihydroneopterin triphosphate pyrophosphohydolase type 2 No genes
Dihydropteroate synthase (EC 2.5.1.15) SO1198 folP
FolM Alternative dihydrofolate reductase 1 SO0772
Folate biosynthesis protein PTPS-III, catalyzes a reaction that bypasses dihydroneopterin aldolase (FolB) No genes
Folate transporter 3 No genes
Folylpolyglutamate synthase (EC 6.3.2.17) No genes
Formate--tetrahydrofolate ligase (EC 6.3.4.3) SO0560 fhs
GTP cyclohydrolase I (EC 3.5.4.16) type 1 SO4254 folE
GTP cyclohydrolase I (EC 3.5.4.16) type 2 No genes
Methionyl-tRNA formyltransferase (EC 2.1.2.9) SO0031 fmt
Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) SO1792 folD
Non functional Dihydropteroate synthase 2 No genes
Nucleoside triphosphate pyrophosphohydrolase MazG No genes
Para-aminobenzoate synthase, amidotransferase component (EC 2.6.1.85) SO0613 pabA
Para-aminobenzoate synthase, aminase component (EC 2.6.1.85) SO2221 pabB
PqqC-like protein No genes
Putative DHNTP pyrophosphatase No genes
Related to Dihydropteroate synthase No genes
Serine hydroxymethyltransferase (EC 2.1.2.1) SO3471 glyA
Substrate-specific component FolT of folate ECF transporter No genes
Thymidine kinase (EC 2.7.1.21) SO3140
Thymidylate synthase (EC 2.1.1.45) SO1335 thyA
Thymidylate synthase thyX (EC 2.1.1.-) No genes
Transaldolase (EC 2.2.1.2) SO3546 tal
Transmembrane component of general energizing module of ECF transporters No genes
Xanthosine/inosine triphosphate pyrophosphatase No genes
alternate gene name: yzbB No genes

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