| Role | Gene | Name | |
| Acyl carrier protein associated with anthrachelin biosynthesis | No genes | | |
| Antibiotic biosynthesis monooxygenase domain-containing protein | No genes | | |
| Cell surface protein IsdA, transfers heme from hemoglobin to apo-IsdC | No genes | | |
| Cell surface protein IsdA1 | No genes | | |
| Cell surface protein Shp, transfers heme from hemoglobin to apo-SiaA/HtsA | No genes | | |
| Cell surface receptor IsdB for hemoglobin and hemoglobin-haptoglobin complexes | No genes | | |
| Cell surface receptor IsdH for hemoglobin-haptoglobin complexes | No genes | | |
| Heme ABC transporter (Streptococcus), ATP-binding protein | No genes | | |
| Heme ABC transporter (Streptococcus), heme and hemoglobin-binding protein SiaA/HtsA | No genes | | |
| Heme ABC transporter (Streptococcus), permease protein | No genes | | |
| Heme ABC transporter, ATPase component HmuV | No genes | | |
| Heme ABC transporter, cell surface heme and hemoprotein receptor HmuT | No genes | | |
| Heme ABC transporter, permease protein HmuU | No genes | | |
| Heme ABC type transporter HtsABC, heme-binding protein | No genes | | |
| Heme ABC type transporter HtsABC, permease protein HtsB | No genes | | |
| Heme ABC type transporter HtsABC, permease protein HtsC | No genes | | |
| Heme efflux system ATPase HrtA | No genes | | |
| Heme efflux system permease HrtB | No genes | | |
| Heme oxygenase (EC 1.14.99.3) | No genes | | |
| Heme oxygenase HemO, associated with heme uptake | No genes | | |
| Heme transporter IsdDEF, lipoprotein IsdE | No genes | | |
| Heme transporter IsdDEF, membrane component IsdD | No genes | | |
| Heme transporter IsdDEF, permease component IsdF | No genes | | |
| Heme transporter analogous to IsdDEF, ATP-binding protein | No genes | | |
| Heme-degrading cytoplasmic oxygenase IsdG | No genes | | |
| Heme-degrading cytoplasmic oxygenase IsdI | No genes | | |
| Hemin transport protein HmuS | No genes | | |
| Hemoglobin, heme-dependent two component system response regulator ChrA | No genes | | |
| Hemoglobin, heme-dependent two component system sensory histidine kinase ChrS | No genes | | |
| Hemoglobin-dependent two component system response regulator HrrA | No genes | | |
| Hemoglobin-dependent two component system, sensory histidine kinase HrrS | No genes | | |
| Hypothetical protein DUF454 | RR42_RS21675 | | |
| Hypothetical protein GBAA1985 associated with anthrachelin biosynthesis, unique | No genes | | |
| Hypothetical protein GBAA1986 associated with anthrachelin biosynthesis, isomerase-like TIM barrel domain | No genes | | |
| Hypothetical similar to CcmC, putative heme lyase for CcmE | No genes | | |
| Hypothetical, distant similarity with heme-degrading oxygenase IsdG | No genes | | |
| Iron compound ABC uptake transporter ATP-binding protein | No genes | | |
| Iron compound ABC uptake transporter ATP-binding protein PiaD | No genes | | |
| Iron compound ABC uptake transporter ATP-binding protein PiuD | No genes | | |
| Iron compound ABC uptake transporter permease protein | No genes | | |
| Iron compound ABC uptake transporter permease protein PiaB | No genes | | |
| Iron compound ABC uptake transporter permease protein PiaC | No genes | | |
| Iron compound ABC uptake transporter permease protein PiuB | No genes | | |
| Iron compound ABC uptake transporter permease protein PiuC | No genes | | |
| Iron compound ABC uptake transporter substrate-binding protein | No genes | | |
| Iron compound ABC uptake transporter substrate-binding protein PiaA | No genes | | |
| Iron compound ABC uptake transporter substrate-binding protein PiuA | No genes | | |
| Iron-dependent repressor IdeR/DtxR | No genes | | |
| LPXTG specific sortase A | No genes | | |
| Long-chain-fatty-acid--CoA ligase associated with anthrachelin biosynthesis | No genes | | |
| Metallo-beta-lactamase superfamily domain protein in prophage | No genes | | |
| NPQTN cell wall anchored protein IsdC | No genes | | |
| NPQTN specific sortase B | No genes | | |
| Putative ABC transporter (ATP-binding protein), spy1791 homolog | No genes | | |
| Putative ABC transporter ATP-binding protein, spy1790 homolog | No genes | | |
| Putative siderophore biosynthesis protein GBAA1981 | No genes | | |
| Putative siderophore biosynthesis protein GBAA1982 | No genes | | |
| Sensor histidine kinase colocalized with HrtAB transporter | No genes | | |
| Similar to hypothetical protein DUF454 | No genes | | |
| Sortase A, LPXTG specific | No genes | | |
| Streptococcal cell surface hemoprotein receptor Shr | No genes | | |
| Two-component response regulator SA14-24 | No genes | | |
| Two-component response regulator colocalized with HrtAB transporter | No genes | | |
| Two-component sensor kinase SA14-24 | No genes | | |
| Uncharacterized iron compound ABC uptake transporter, ATP-binding protein | No genes | | |
| Uncharacterized iron compound ABC uptake transporter, permease protein | No genes | | |
| Uncharacterized iron compound ABC uptake transporter, substrate-binding protein | No genes | | |
| Zn-dependent hydrolase (beta-lactamase superfamily) | No genes | | |